O14672: Disintegrin and metalloproteinase domain-containing protein 10 (Human)

Protein names
  • Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10)
  • CDw156 (ADAM 10)
  • Kuzbanian protein homolog (ADAM 10)
  • Mammalian disintegrin-metalloprotease (ADAM 10)
  • ADA10
Gene names ADAM10 (KUZ)
Organism Homo sapiens
Protease Family M12 (MEROPS)
Protease ID M12.210 (MEROPS)
Chromosome 15

Sequence

        10         20         30         40         50         60 
MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL 
        70         80         90        100        110        120 
RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI 
       130        140        150        160        170        180 
DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE 
       190        200        210        220        230        240 
RMRKYQMTGV EEVTQIPQEE HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE 
       250        260        270        280        290        300 
AVIAQISSHV KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF 
       310        320        330        340        350        360 
LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY SDGKKKSLNT 
       370        380        390        400        410        420 
GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT PGESKNLGQK ENGNYIMYAR 
       430        440        450        460        470        480 
ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK 
       490        500        510        520        530        540 
DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT 
       550        560        570        580        590        600 
ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK 
       610        620        630        640        650        660 
KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA DGPLARLKKA 
       670        680        690        700        710        720 
IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS VHTPSSNPKL PPPKPLPGTL 
       730        740    
KRRRPPQPIQ QPQRQRPRES YQMGHMRR

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
700
Chains:
 
 
N-termini:
N
NNNN
N
 
C-termini:
CCCC
 
Cleavage sites:
  
 
 
 
 
 
 
Features:
  
     
 
Binding & active sites:
     
 
Sequence variations:
        
 
Topology:
   
 
(GHIYG(109)|(110)EEGSF)
109,748

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

109,748,672,20 TOPO_DOM - Extracellular (Potential). (20|672)
109,748,213,20 PROPEP - By similarity. (20|213)
 
(LRKKR(213)|(214)TTSAE)
213,748

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Fahrenholz F Anders A et al.:Regulation of the alpha-secreta... (S08.071) unknown yes

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Fahrenholz F Anders A et al.:Regulation of the alpha-secreta... (S08.071) unknown yes

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Targeted features: ?

213,748,672,20 TOPO_DOM - Extracellular (Potential). (20|672)

Affected feature boundaries: ?

213,748,212,212 CONFLICT - K -> R (in Ref. 2; CAA88463). (212|212)
213,748,748,214 CHAIN - Disintegrin and metalloproteinase domain- containing protein 10. (214|748)
213,748,213,20 PROPEP - By similarity. (20|213)
 
unknown-19GQYGNP...
19,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-20QYGNPL...
20,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

20,748,672,20 TOPO_DOM - Extracellular (Potential). (20|672)
20,748,213,20 PROPEP - By similarity. (20|213)
 
unknown-110EEGSFS...
110,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC18208 indirect unknown (unknown)
 
unknown-132GGTFYV...
132,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wildes D. et al: Sampling the N-terminal proteome of human blood unknown unknown (unknown)
 
unknown-214TTSAEK...
214,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26940 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27239 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26533 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26799 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9657 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27091 indirect unknown (unknown)

Affected feature boundaries: ?

214,748,748,214 CHAIN - Disintegrin and metalloproteinase domain- containing protein 10. (214|748)
 
unknown-216SAEKNT...
216,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 

Protein C-Termini [export]

...GHIYG109-unknown
109,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC18208 indirect unknown (unknown)
 
...LRKKR213-unknown
213,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26940 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27239 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26533 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26799 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9657 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27091 indirect unknown (unknown)

Affected feature boundaries: ?

213,748,213,20 PROPEP - By similarity. (20|213)
 
...EKKRN449-unknown
449,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000453952 unknown unknown (unknown)
 
...GHMRR748-unknown
748,748

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

748,748,748,694 TOPO_DOM - Cytoplasmic (Potential). (694|748)
748,748,748,214 CHAIN - Disintegrin and metalloproteinase domain- containing protein 10. (214|748)
 
39 (VAAA.|.VVSH)
39,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Moss ML Hinkle CL et al.:Multiple metalloproteinases pro... (M12.210) unknown yes
 
39 ()
39,163

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC70 indirect unknown
 
76 (LAQA.|.VRSS)
76,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lichenstein HS Rosendahl MS et al.:Identification and characteriza... (M12.210) unknown yes
 
80 (DQMA.|.QKSQ)
80,321

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Werb Z Lemieux GA et al.:The low affinity IgE receptor (... (M12.210) unknown unknown
 
99 (RAEQ.|.QRLK)
99,321

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Werb Z Lemieux GA et al.:The low affinity IgE receptor (... (M12.210) unknown unknown
 
101 (EQQR.|.LKSQ)
101,321

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Werb Z Lemieux GA et al.:The low affinity IgE receptor (... (M12.210) unknown unknown
 
104 ()
104,246

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC73 indirect unknown
 
111 (NMKH.|.MAGA)
111,253

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haik S Laffont-Proust I et al.:The N-terminal cleavage of cell... (M12.210) unknown none
 
113 (SFEM.|.QKGD)
113,261

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
555 ()
555,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
556 ()
556,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
593 ()
593,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
594 ()
594,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
611 ()
611,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
612 ()
612,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
612 ()
612,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
613 ()
613,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
630 ()
630,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
631 ()
631,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
649 ()
649,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
650 ()
650,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
662 ()
662,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
663 ()
663,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
667 ()
667,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
668 ()
668,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
668 ()
668,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC75 indirect unknown
 
669 ()
669,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC85 indirect unknown
 
686 (VHHQ.|.KLVF)
686,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ADA10_HUMAN -> A4_HUMAN @686 unknown yes
 
687 (HHQK.|.LVFF)
687,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
803 (HVNH.|.LIVQ)
803,955

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
834 (SIAT.|.VVII)
834,955

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
837 (TVVI.|.IISV)
837,955

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
812 (HPSH.|.VLSS)
812,956

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
849 (SAAT.|.LIIV)
849,956

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
852 (TLII.|.VVCV)
852,956

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
824 ()
824,968

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC99 indirect unknown
 
861 ()
861,968

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC101 indirect unknown
 
864 ()
864,968

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC103 indirect unknown
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect
  • direct

Physiological relevance ?

  • none
  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?