O43889: Cyclic AMP-responsive element-binding protein 3 (Human)

Protein names
  • Cyclic AMP-responsive element-binding protein 3 (CREB-3)
  • Leucine zipper protein (CREB-3)
  • Luman (CREB-3)
  • Transcription factor LZIP-alpha (CREB-3)
  • CREB3
Gene names CREB3 (LZIP)
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 9

Isoforms

  • Isoform 2 of Cyclic AMP-responsive element-binding protein 3 (O43889-2): sequence view | extended view
  • Isoform 3 of Cyclic AMP-responsive element-binding protein 3 (O43889-3): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV DDLLCSLLSP 
        70         80         90        100        110        120 
PASLNILSSS NPCLVHHDHT YSLPRETVSM DLGECEISLT GRTGFMGLAI HTFPFAESES 
       130        140        150        160        170        180 
CRKEGTQMTP QHMEELAEQE IARLVLTDEE KSLLEKEGLI LPETLPLTKT EEQILKRVRR 
       190        200        210        220        230        240 
KIRNKRSAQE SRRKKKVYVG GLESRVLKYT AQNMELQNKV QLLEEQNLSL LDQLRKLQAM 
       250        260        270        280        290        300 
VIEISNKTSS SSTCILVLLV SFCLLLVPAM YSSDTRGSLP AEHGVLSRQL RALPSEDPYQ 
       310        320        330        340        350        360 
LELPALQSEV PKDSTHQWLD GSDCVLQAPG NTSCLLHYMP QAPSAEPPLE WPFPDLFSEP 
       370        380        390    
LCRGPILPLQ ANLTRKGGWL PTGSPSVILQ DRYSG

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
Chains:
 
 
 
N-termini:

NN
 
C-termini:

CCC
 
Cleavage sites:
 
 
Topology:
   
 
(SRQLR(291)|(292)ALPSE)
291,395

Membrane-bound transcription factor site-1 protease (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes

Targeted features: ?

291,395,395,272 TOPO_DOM - Lumenal (Potential). (272|395)
291,395,395,1 CHAIN - Cyclic AMP-responsive element-binding protein 3. (1|395)

Affected feature boundaries: ?

291,395,291,291 MUTAGEN - R->G: Inhibits proteolytic cleavage and transcriptional activation. (291|291)
291,395,291,290 SITE - Cleavage; by PS1 (Probable). (290|291)
291,395,291,291 MUTAGEN - R->G: Inhibits proteolytic cleavage and transcriptional activation. (291|291)
 
unknown-1MELELD...
1,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt71665 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt71666 indirect unknown (unknown)

Affected feature boundaries: ?

1,395,254,1 TOPO_DOM - Cytoplasmic (Potential). (1|254)
1,395,395,1 CHAIN - Cyclic AMP-responsive element-binding protein 3. (1|395)
1,395,0,1 CHAIN - Processed cyclic AMP-responsive element- binding protein 3. (1|0)
1,395,92,1 REGION - Transcription activation (acidic). (1|92)
 
unknown-292ALPSED...
292,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16818 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt148445 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149080 indirect unknown (unknown)
 

Protein C-Termini [export]

...DRYSG0-unknown
0,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,395,0,1 CHAIN - Processed cyclic AMP-responsive element- binding protein 3. (1|0)
 
...SRQLR291-unknown
291,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16818 indirect unknown (unknown)

Affected feature boundaries: ?

291,395,291,290 SITE - Cleavage; by PS1 (Probable). (290|291)
291,395,291,291 MUTAGEN - R->G: Inhibits proteolytic cleavage and transcriptional activation. (291|291)
 
...DRYSG395-unknown
395,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt67284 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt67283 indirect unknown (unknown)

Affected feature boundaries: ?

395,395,395,272 TOPO_DOM - Lumenal (Potential). (272|395)
395,395,395,1 CHAIN - Cyclic AMP-responsive element-binding protein 3. (1|395)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?