P02469: Laminin subunit beta-1 (Mouse)

Protein names
  • Laminin subunit beta-1
  • Laminin B1 chain
  • Laminin-1 subunit beta
  • Laminin-10 subunit beta
  • Laminin-12 subunit beta
  • Laminin-2 subunit beta
  • Laminin-6 subunit beta
  • Laminin-8 subunit beta
  • LAMB1
Gene names Lamb1 (Lamb-1, Lamb1-1)
Organism Mus musculus
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 12

Sequence

        10         20         30         40         50         60 
MGLLQVFAFG VLALWGTRVC AQEPEFSYGC AEGSCYPATG DLLIGRAQKL SVTSTCGLHK 
        70         80         90        100        110        120 
PEPYCIVSHL QEDKKCFICD SRDPYHETLN PDSHLIENVV TTFAPNRLKI WWQSENGVEN 
       130        140        150        160        170        180 
VTIQLDLEAE FHFTHLIMTF KTFRPAAMLI ERSSDFGKAW GVYRYFAYDC ESSFPGISTG 
       190        200        210        220        230        240 
PMKKVDDIIC DSRYSDIEPS TEGEVIFRAL DPAFKIEDPY SPRIQNLLKI TNLRIKFVKL 
       250        260        270        280        290        300 
HTLGDNLLDS RMEIREKYYY AVYDMVVRGN CFCYGHASEC APVDGVNEEV EGMVHGHCMC 
       310        320        330        340        350        360 
RHNTKGLNCE LCMDFYHDLP WRPAEGRNSN ACKKCNCNEH SSSCHFDMAV FLATGNVSGG 
       370        380        390        400        410        420 
VCDNCQHNTM GRNCEQCKPF YFQHPERDIR DPNLCEPCTC DPAGSENGGI CDGYTDFSVG 
       430        440        450        460        470        480 
LIAGQCRCKL HVEGERCDVC KEGFYDLSAE DPYGCKSCAC NPLGTIPGGN PCDSETGYCY 
       490        500        510        520        530        540 
CKRLVTGQRC DQCLPQHWGL SNDLDGCRPC DCDLGGALNN SCSEDSGQCS CLPHMIGRQC 
       550        560        570        580        590        600 
NEVESGYYFT TLDHYIYEAE EANLGPGVIV VERQYIQDRI PSWTGPGFVR VPEGAYLEFF 
       610        620        630        640        650        660 
IDNIPYSMEY EILIRYEPQL PDHWEKAVIT VQRPGKIPAS SRCGNTVPDD DNQVVSLSPG 
       670        680        690        700        710        720 
SRYVVLPRPV CFEKGMNYTV RLELPQYTAS GSDVESPYTF IDSLVLMPYC KSLDIFTVGG 
       730        740        750        760        770        780 
SGDGEVTNSA WETFQRYRCL ENSRSVVKTP MTDVCRNIIF SISALIHQTG LACECDPQGS 
       790        800        810        820        830        840 
LSSVCDPNGG QCQCRPNVVG RTCNRCAPGT FGFGPNGCKP CDCHLQGSAS AFCDAITGQC 
       850        860        870        880        890        900 
HCFQGIYARQ CDRCLPGYWG FPSCQPCQCN GHALDCDTVT GECLSCQDYT TGHNCERCLA 
       910        920        930        940        950        960 
GYYGDPIIGS GDHCRPCPCP DGPDSGRQFA RSCYQDPVTL QLACVCDPGY IGSRCDDCAS 
       970        980        990       1000       1010       1020 
GFFGNPSDFG GSCQPCQCHH NIDTTDPEAC DKETGRCLKC LYHTEGDHCQ LCQYGYYGDA 
      1030       1040       1050       1060       1070       1080 
LRQDCRKCVC NYLGTVKEHC NGSDCHCDKA TGQCSCLPNV IGQNCDRCAP NTWQLASGTG 
      1090       1100       1110       1120       1130       1140 
CGPCNCNAAH SFGPSCNEFT GQCQCMPGFG GRTCSECQEL FWGDPDVECR ACDCDPRGIE 
      1150       1160       1170       1180       1190       1200 
TPQCDQSTGQ CVCVEGVEGP RCDKCTRGYS GVFPDCTPCH QCFALWDAII GELTNRTHKF 
      1210       1220       1230       1240       1250       1260 
LEKAKALKIS GVIGPYRETV DSVEKKVNEI KDILAQSPAA EPLKNIGILF EEAEKLTKDV 
      1270       1280       1290       1300       1310       1320 
TEKMAQVEVK LTDTASQSNS TAGELGALQA EAESLDKTVK ELAEQLEFIK NSDIQGALDS 
      1330       1340       1350       1360       1370       1380 
ITKYFQMSLE AEKRVNASTT DPNSTVEQSA LTRDRVEDLM LERESPFKEQ QEEQARLLDE 
      1390       1400       1410       1420       1430       1440 
LAGKLQSLDL SAVAQMTCGT PPGADCSESE CGGPNCRTDE GEKKCGGPGC GGLVTVAHSA 
      1450       1460       1470       1480       1490       1500 
WQKAMDFDRD VLSALAEVEQ LSKMVSEAKV RADEAKQNAQ DVLLKTNATK EKVDKSNEDL 
      1510       1520       1530       1540       1550       1560 
RNLIKQIRNF LTEDSADLDS IEAVANEVLK MEMPSTPQQL QNLTEDIRER VETLSQVEVI 
      1570       1580       1590       1600       1610       1620 
LQQSAADIAR AELLLEEAKR ASKSATDVKV TADMVKEALE EAEKAQVAAE KAIKQADEDI 
      1630       1640       1650       1660       1670       1680 
QGTQNLLTSI ESETAASEET LTNASQRISK LERNVEELKR KAAQNSGEAE YIEKVVYSVK 
      1690       1700       1710       1720       1730       1740 
QNADDVKKTL DGELDEKYKK VESLIAQKTE ESADARRKAE LLQNEAKTLL AQANSKLQLL 
      1750       1760       1770       1780    
EDLERKYEDN QKYLEDKAQE LVRLEGEVRS LLKDISEKVA VYSTCL

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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Chains:
 
 
N-termini:
NNNNNNNNN
 
C-termini:
CCCCCCCC
 
Cleavage sites:
       
 
Sequence variations:
       
 
(EPEFS(27)|(28)YGCAE)
27,1786

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMB1_MOUSE @27 unknown yes

Targeted features: ?

27,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
 
(FTHLI(137)|(138)MTFKT)
137,1786

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMB1_MOUSE @137 unknown yes

Targeted features: ?

137,1786,270,31 DOMAIN - Laminin N-terminal. (31|270)
137,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
137,1786,142,122 STRAND - (122|142)
 
(CHHNI(982)|(983)DTTDP)
982,1786

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMB1_MOUSE @982 unknown yes

Targeted features: ?

982,1786,1027,976 DOMAIN - Laminin EGF-like 10. (976|1027)
982,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
982,1786,990,976 DISULFID - By similarity. (976|990)
982,1786,997,978 DISULFID - By similarity. (978|997)
 
(TRDRV(1356)|(1357)EDLML)
1356,1786

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMB1_MOUSE @1356 unknown yes

Targeted features: ?

1356,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
1356,1786,1397,1179 REGION - Domain II. (1179|1397)
 
(VAQMT(1397)|(1398)CGTPP)
1397,1786

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMB1_MOUSE @1397 unknown yes

Targeted features: ?

1397,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)

Affected feature boundaries: ?

1397,1786,1397,1179 REGION - Domain II. (1179|1397)
1397,1786,1430,1398 REGION - Domain alpha. (1398|1430)
 
(TLSQV(1557)|(1558)EVILQ)
1557,1786

Matrix metalloproteinase-9 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP9_MOUSE -> LAMB1_MOUSE @1557 unknown yes

Targeted features: ?

1557,1786,1778,1448 COILED - Potential. (1448|1778)
1557,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
1557,1786,1786,1431 REGION - Domain I. (1431|1786)
 
(KKVES(1703)|(1704)LIAQK)
1703,1786

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Targeted features: ?

1703,1786,1778,1448 COILED - Potential. (1448|1778)
1703,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
1703,1786,1786,1431 REGION - Domain I. (1431|1786)
 
unknown-22QEPEFS...
22,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

22,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
 
unknown-28YGCAEG...
28,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32176 indirect unknown (unknown)
 
unknown-138MTFKTF...
138,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32177 indirect unknown (unknown)
 
unknown-983DTTDPE...
983,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32178 indirect unknown (unknown)
 
unknown-1357EDLMLE...
1357,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32179 indirect unknown (unknown)
 
unknown-1398CGTPPG...
1398,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32180 indirect unknown (unknown)

Affected feature boundaries: ?

1398,1786,1430,1398 REGION - Domain alpha. (1398|1430)
 
pyrrolidone carboxylic acid-1442QKAMDF...
1442,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Overall CM. Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... direct likely 0.0 (unknown)
 
unknown-1558EVILQQ...
1558,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34512 indirect unknown (unknown)
 
unknown-1704LIAQKT...
1704,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33203 indirect unknown (unknown)
 

Protein C-Termini [export]

...EPEFS27-unknown
27,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32176 indirect unknown (unknown)
 
...FTHLI137-unknown
137,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32177 indirect unknown (unknown)
 
...CHHNI982-unknown
982,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32178 indirect unknown (unknown)
 
...TRDRV1356-unknown
1356,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32179 indirect unknown (unknown)
 
...VAQMT1397-unknown
1397,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32180 indirect unknown (unknown)

Affected feature boundaries: ?

1397,1786,1397,1179 REGION - Domain II. (1179|1397)
 
...TLSQV1557-unknown
1557,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34512 indirect unknown (unknown)
 
...KKVES1703-unknown
1703,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33203 indirect unknown (unknown)
 
...YSTCL1786-unknown
1786,1786

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1786,1786,1786,22 CHAIN - Laminin subunit beta-1. (22|1786)
1786,1786,1786,1431 REGION - Domain I. (1431|1786)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect
  • direct

Physiological relevance ?

  • yes
  • none
  • unknown
  • likely

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?