P03956: Interstitial collagenase (Human)

Protein names
  • Interstitial collagenase
  • Fibroblast collagenase
  • Matrix metalloproteinase-1 Short=MMP-1
  • MMP1
Gene names MMP1 (CLG)
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.001 (MEROPS)
Chromosome 11

Sequence

        10         20         30         40         50         60 
MHSFPPLLLL LFWGVVSHSF PATLETQEQD VDLVQKYLEK YYNLKNDGRQ VEKRRNSGPV 
        70         80         90        100        110        120 
VEKLKQMQEF FGLKVTGKPD AETLKVMKQP RCGVPDVAQF VLTEGNPRWE QTHLTYRIEN 
       130        140        150        160        170        180 
YTPDLPRADV DHAIEKAFQL WSNVTPLTFT KVSEGQADIM ISFVRGDHRD NSPFDGPGGN 
       190        200        210        220        230        240 
LAHAFQPGPG IGGDAHFDED ERWTNNFREY NLHRVAAHEL GHSLGLSHST DIGALMYPSY 
       250        260        270        280        290        300 
TFSGDVQLAQ DDIDGIQAIY GRSQNPVQPI GPQTPKACDS KLTFDAITTI RGEVMFFKDR 
       310        320        330        340        350        360 
FYMRTNPFYP EVELNFISVF WPQLPNGLEA AYEFADRDEV RFFKGNKYWA VQGQNVLHGY 
       370        380        390        400        410        420 
PKDIYSSFGF PRTVKHIDAA LSEENTGKTY FFVANKYWRY DEYKRSMDPG YPKMIAHDFP 
       430        440        450        460    
GIGHKVDAVF MKDGFFYFFH GTRQYKFDPK TKRILTLQKA NSWFNCRKN

Annotation ?

Network neighborhood
[show protein-protein interactions]
(PATLE(25)|(26)TQEQD)
25,469

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

25,469,99,20 PROPEP - Activation peptide. (20|99)
 
(TLETQ(27)|(28)EQDVD)
27,469

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

27,469,99,20 PROPEP - Activation peptide. (20|99)
 
(QVEKR(54)|(55)RNSGP)
54,469

Plasma kallikrein (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Nagase H Suzuki K et al.:Mechanisms of activation of tis... (S01.212) unknown yes

Targeted features: ?

54,469,99,20 PROPEP - Activation peptide. (20|99)
 
(PDAET(83)|(84)LKVMK)
83,469

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Desrochers PE et al.:Interstitial collagenase (matri... (M10.001) unknown yes

Targeted features: ?

83,469,99,20 PROPEP - Activation peptide. (20|99)
 
(ETLKV(86)|(87)MKQPR)
86,469

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP1_HUMAN -> MMP1_HUMAN @86 unknown yes

Targeted features: ?

86,469,99,20 PROPEP - Activation peptide. (20|99)
 
(MKQPR(91)|(92)CGVPD)
91,469

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Targeted features: ?

91,469,99,20 PROPEP - Activation peptide. (20|99)

Affected feature boundaries: ?

91,469,92,92 METAL - Zinc 2; in inhibited form. (92|92)
 
(PDVAQ(99)|(100)FVLTE)
99,469

Plasminogen (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops PLMN_HUMAN -> MMP1_HUMAN @99 unknown yes

Matrilysin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Woessner JF Jr Abramson SR et al.:Characterization of rat uterine... (M10.008) unknown yes

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Desrochers PE et al.:Interstitial collagenase (matri... (M10.001) unknown yes

Stromelysin-1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Nagase H Suzuki K et al.:Mechanisms of activation of tis... (S01.212) unknown yes

Affected feature boundaries: ?

99,469,469,100 CHAIN - Interstitial collagenase. (100|469)
99,469,269,100 CHAIN - 22 kDa interstitial collagenase. (100|269)
99,469,99,20 PROPEP - Activation peptide. (20|99)
 
(DVAQF(100)|(101)VLTEG)
100,469

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Desrochers PE et al.:Interstitial collagenase (matri... (M10.001) unknown yes

Affected feature boundaries: ?

100,469,469,100 CHAIN - Interstitial collagenase. (100|469)
100,469,269,100 CHAIN - 22 kDa interstitial collagenase. (100|269)
100,469,99,20 PROPEP - Activation peptide. (20|99)
 
(VAQFV(101)|(102)LTEGN)
101,469

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Desrochers PE et al.:Interstitial collagenase (matri... (M10.001) unknown yes

Targeted features: ?

101,469,276,98 REGION - Metalloprotease. (98|276)
 
(AQFVL(102)|(103)TEGNP)
102,469

Chymase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Caughey GH Raymond WW et al.:Albumin is a substrate of human... (S01.140) unknown yes

Targeted features: ?

102,469,276,98 REGION - Metalloprotease. (98|276)

Affected feature boundaries: ?

102,469,106,103 STRAND - (103|106)
 
(NLAHA(184)|(185)FQPGP)
184,469

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

184,469,469,100 CHAIN - Interstitial collagenase. (100|469)
184,469,269,100 CHAIN - 22 kDa interstitial collagenase. (100|269)
184,469,276,98 REGION - Metalloprotease. (98|276)

Affected feature boundaries: ?

184,469,183,183 METAL - Zinc 1. (183|183)
184,469,184,182 STRAND - (182|184)
 
(NPVQP(269)|(270)IGPQT)
269,469

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Desrochers PE et al.:Interstitial collagenase (matri... (M10.001) unknown yes

Targeted features: ?

269,469,469,100 CHAIN - Interstitial collagenase. (100|469)
269,469,276,98 REGION - Metalloprotease. (98|276)

Affected feature boundaries: ?

269,469,270,269 SITE - Cleavage; by autolysis. (269|270)
269,469,269,100 CHAIN - 22 kDa interstitial collagenase. (100|269)
269,469,469,270 CHAIN - 27 kDa interstitial collagenase. (270|469)
 
unknown-26TQEQDV...
26,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17077 indirect unknown (unknown)
 
unknown-28EQDVDL...
28,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC18418 indirect unknown (unknown)
 
unknown-55RNSGPV...
55,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16697 indirect unknown (unknown)
 
unknown-84LKVMKQ...
84,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21728 indirect unknown (unknown)
 
unknown-87MKQPRC...
87,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21729 indirect unknown (unknown)
 
unknown-92CGVPDV...
92,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26975 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27271 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26564 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26830 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27122 indirect unknown (unknown)

Affected feature boundaries: ?

92,469,92,92 METAL - Zinc 2; in inhibited form. (92|92)
 
unknown-100FVLTEG...
100,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27475 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC23998 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21730 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC23798 indirect unknown (unknown)

Affected feature boundaries: ?

100,469,469,100 CHAIN - Interstitial collagenase. (100|469)
100,469,269,100 CHAIN - 22 kDa interstitial collagenase. (100|269)
 
unknown-101VLTEGN...
101,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21731 indirect unknown (unknown)
 
unknown-102LTEGNP...
102,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21732 indirect unknown (unknown)
 
unknown-103TEGNPR...
103,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC8411 indirect unknown (unknown)

Affected feature boundaries: ?

103,469,106,103 STRAND - (103|106)
 
unknown-185FQPGPG...
185,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17078 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC18419 indirect unknown (unknown)
 
unknown-270IGPQTP...
270,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21733 indirect unknown (unknown)

Affected feature boundaries: ?

270,469,469,270 CHAIN - 27 kDa interstitial collagenase. (270|469)
 

Protein C-Termini [export]

...PATLE25-unknown
25,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17077 indirect unknown (unknown)
 
...TLETQ27-unknown
27,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC18418 indirect unknown (unknown)
 
...QVEKR54-unknown
54,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16697 indirect unknown (unknown)
 
...PDAET83-unknown
83,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21728 indirect unknown (unknown)
 
...ETLKV86-unknown
86,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21729 indirect unknown (unknown)
 
...MKQPR91-unknown
91,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26975 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27271 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26564 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26830 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27122 indirect unknown (unknown)
 
...PDVAQ99-unknown
99,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC27475 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC23998 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21730 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC23798 indirect unknown (unknown)

Affected feature boundaries: ?

99,469,99,20 PROPEP - Activation peptide. (20|99)
 
...DVAQF100-unknown
100,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21731 indirect unknown (unknown)
 
...VAQFV101-unknown
101,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21732 indirect unknown (unknown)
 
...AQFVL102-unknown
102,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC8411 indirect unknown (unknown)
 
...NLAHA184-unknown
184,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17078 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC18419 indirect unknown (unknown)

Affected feature boundaries: ?

184,469,184,182 STRAND - (182|184)
 
...NPVQP269-unknown
269,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21733 indirect unknown (unknown)

Affected feature boundaries: ?

269,469,269,100 CHAIN - 22 kDa interstitial collagenase. (100|269)
 
...NCRKN469-unknown
469,469

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

469,469,469,100 CHAIN - Interstitial collagenase. (100|469)
469,469,469,270 CHAIN - 27 kDa interstitial collagenase. (270|469)
 
4 (MKVS.|.AALL)
4,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
73 (RGKE.|.VCAD)
73,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
4 (MKAS.|.AALL)
4,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
27 (QPVG.|.INTS)
27,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM McQuibban GA et al.:Matrix metalloproteinase proces... (M10.013)