P07711: Cathepsin L1 (Human)

Protein names
  • Cathepsin L1
  • Cathepsin L
  • Major excreted protein Short=MEP
  • CATL1
Gene names CTSL
Organism Homo sapiens
Protease Family C01 (MEROPS)
Protease ID C01.032 (MEROPS)
Chromosome 9

Sequence

        10         20         30         40         50         60 
MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNMKMIE 
        70         80         90        100        110        120 
LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW 
       130        140        150        160        170        180 
REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG 
       190        200        210        220        230        240 
GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA 
       250        260        270        280        290        300 
TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN 
       310        320        330    
SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTV

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
Chains:
  
 
N-termini:
N
NN
N
N
NN
 
C-termini:
CC
C
C
CCC
 
Cleavage sites:
     
 
Features:
   
 
Binding & active sites:
   
 
Sequence variations:
  
 
(SATLT(20)|(21)FDHSL)
20,333

Cathepsin L1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Mort JS Menard R et al.:Autocatalytic processing of rec... (C01.032) unknown yes
 
(KGKVF(106)|(107)QEPLF)
106,333

Cathepsin L1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Mort JS Menard R et al.:Autocatalytic processing of rec... (C01.032) unknown yes

Targeted features: ?

106,333,113,18 PROPEP - Activation peptide. (18|113)

Affected feature boundaries: ?

106,333,105,103 STRAND - (103|105)
 
(GKVFQ(107)|(108)EPLFY)
107,333

Cathepsin L1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Mort JS Menard R et al.:Autocatalytic processing of rec... (C01.032) unknown yes

Targeted features: ?

107,333,113,18 PROPEP - Activation peptide. (18|113)
 
(EPLFY(112)|(113)EAPRS)
112,333

Cathepsin L1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Mort JS Menard R et al.:Autocatalytic processing of rec... (C01.032) unknown yes
 
(PLFYE(113)|(114)APRSV)
113,333

Cathepsin L1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Mort JS Menard R et al.:Autocatalytic processing of rec... (C01.032) unknown yes

Affected feature boundaries: ?

113,333,288,114 CHAIN - Cathepsin L1 heavy chain. (114|288)
113,333,113,18 PROPEP - Activation peptide. (18|113)
 
unknown-18TLTFDH...
18,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

18,333,113,18 PROPEP - Activation peptide. (18|113)
 
unknown-21FDHSLE...
21,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5442 indirect unknown (unknown)
 
unknown-107QEPLFY...
107,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5443 indirect unknown (unknown)
 
unknown-108EPLFYE...
108,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5444 indirect unknown (unknown)
 
unknown-113EAPRSV...
113,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5445 indirect unknown (unknown)
 
unknown-114APRSVD...
114,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC5446 indirect unknown (unknown)

Affected feature boundaries: ?

114,333,288,114 CHAIN - Cathepsin L1 heavy chain. (114|288)
 
unknown-292NNKYWL...
292,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

292,333,333,292 CHAIN - Cathepsin L1 light chain. (292|333)
 

Protein C-Termini [export]

...SATLT20-unknown
20,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5442 indirect unknown (unknown)
 
...KGKVF106-unknown
106,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5443 indirect unknown (unknown)
 
...GKVFQ107-unknown
107,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5444 indirect unknown (unknown)
 
...EPLFY112-unknown
112,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5445 indirect unknown (unknown)
 
...PLFYE113-unknown
113,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC5446 indirect unknown (unknown)

Affected feature boundaries: ?

113,333,113,18 PROPEP - Activation peptide. (18|113)
 
...GFEST288-unknown
288,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

288,333,288,114 CHAIN - Cathepsin L1 heavy chain. (114|288)
 
...SYPTV333-unknown
333,333

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

333,333,333,292 CHAIN - Cathepsin L1 light chain. (292|333)
 
4 (MSYG.|.RPPP)
4,221

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
4 (MMLG.|.TEGG)
4,449

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
362 (LFLN.|.STAG)
362,449

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
4 (MPYQ.|.YPAL)
4,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
31 (KGIL.|.AADE)
31,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
32 (GILA.|.ADES)
32,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
45 (KRLQ.|.SIGT)
45,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
229 (GTLL.|.KPNM)
229,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
233 (KPNM.|.VTPG)
233,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
271 (ITFL.|.SGGQ)
271,364

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
4 (MDLA.|.AAAE)
4,821

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
501 (SILA.|.AANP)
501,821

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
5 (TEWE.|.TAAP)
5,204

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
5 (ELLG.|.EYVG)
5,100

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
6 (EIVH.|.LQAG)
6,445

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
37 (GTYH.|.GDSD)
37,445

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
6 (SSVG.|.NVAD)
6,1046

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
6 (VAVA.|.GCCH)
6,544

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
7 (ILVT.|.GGVI)
7,591

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
8 (KIFS.|.GSSH)
8,318

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
8 (VHIQ.|.AGQC)
8,444

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none
 
114 (ELVD.|.SVLD)
114,444

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none