P08253: 72 kDa type IV collagenase (Human)

Protein names
  • 72 kDa type IV collagenase
  • 72 kDa gelatinase
  • Gelatinase A
  • Matrix metalloproteinase-2 Short=MMP-2
  • TBE-1
  • MMP2
Gene names MMP2 (CLG4A)
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.003 (MEROPS)
Chromosome 16

Isoforms

  • Isoform 2 of 72 kDa type IV collagenase (P08253-2): sequence view | extended view
  • Isoform 3 of 72 kDa type IV collagenase (P08253-3): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MEALMARGAL TGPLRALCLL GCLLSHAAAA PSPIIKFPGD VAPKTDKELA VQYLNTFYGC 
        70         80         90        100        110        120 
PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP RCGNPDVANY NFFPRKPKWD 
       130        140        150        160        170        180 
KNQITYRIIG YTPDLDPETV DDAFARAFQV WSDVTPLRFS RIHDGEADIM INFGRWEHGD 
       190        200        210        220        230        240 
GYPFDGKDGL LAHAFAPGTG VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN 
       250        260        270        280        290        300 
GKEYNSCTDT GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNAEGQP CKFPFRFQGT 
       310        320        330        340        350        360 
SYDSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV FPFTFLGNKY 
       370        380        390        400        410        420 
ESCTSAGRSD GKMWCATTAN YDDDRKWGFC PDQGYSLFLV AAHEFGHAMG LEHSQDPGAL 
       430        440        450        460        470        480 
MAPIYTYTKN FRLSQDDIKG IQELYGASPD IDLGTGPTPT LGPVTPEICK QDIVFDGIAQ 
       490        500        510        520        530        540 
IRGEIFFFKD RFIWRTVTPR DKPMGPLLVA TFWPELPEKI DAVYEAPQEE KAVFFAGNEY 
       550        560        570        580        590        600 
WIYSASTLER GYPKPLTSLG LPPDVQRVDA AFNWSKNKKT YIFAGDKFWR YNEVKKKMDP 
       610        620        630        640        650        660 
GFPKLIADAW NAIPDNLDAV VDLQGGGHSY FFKGAYYLKL ENQSLKSVKF GSIKSDWLGC 
   

Annotation ?

Network neighborhood
[show protein-protein interactions]
(KESCN(66)|(67)LFVLK)
66,660

Matrix metalloproteinase-14 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Will H et al.:The soluble catalytic domain of... (M10.014) unknown yes

Matrix metalloproteinase-25 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Nie J et al.:Direct activation of pro-matrix... (M10.024) unknown yes

Targeted features: ?

66,660,76,1 VAR_SEQ - Missing (in isoform 2). (1|76)
66,660,109,30 PROPEP - Activation peptide. (30|109)

Affected feature boundaries: ?

66,660,80,67 HELIX - (67|80)
 
(PQTGD(88)|(89)LDQNT)
88,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

88,660,109,30 PROPEP - Activation peptide. (30|109)

Affected feature boundaries: ?

88,660,88,86 STRAND - (86|88)
 
(IETMR(98)|(99)KPRCG)
98,660

Trypsin-2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Stenman UH Sorsa T et al.:Activation of type IV procollag... (S01.258) unknown yes

Targeted features: ?

98,660,109,30 PROPEP - Activation peptide. (30|109)

Affected feature boundaries: ?

98,660,97,91 HELIX - (91|97)
 
(MRKPR(101)|(102)CGNPD)
101,660

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Chiarelli C Cao J et al.:Furin directly cleaves proMMP-2... (S08.071) unknown yes

Targeted features: ?

101,660,109,30 PROPEP - Activation peptide. (30|109)

Affected feature boundaries: ?

101,660,101,101 VARIANT - R -> H (in MONA). (101|101)
101,660,102,102 METAL - Zinc 2; in inhibited form (By similarity). (102|102)
101,660,101,101 VARIANT - R -> H (in MONA). (101|101)
 
(PDVAN(109)|(110)YNFFP)
109,660

Matrix metalloproteinase-14 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Pei D et al.:Transmembrane-deletion mutants ... (M10.014) unknown yes

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Docherty AJ Crabbe T et al.:Human progelatinase A can be ac... (M10.003) unknown yes

Matrix metalloproteinase-25 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Nie J et al.:Direct activation of pro-matrix... (M10.024) unknown yes

Affected feature boundaries: ?

109,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
109,660,221,110 REGION - Collagenase-like 1. (110|221)
109,660,109,30 PROPEP - Activation peptide. (30|109)
 
(TYRII(129)|(130)GYTPD)
129,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

129,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
129,660,221,110 REGION - Collagenase-like 1. (110|221)

Affected feature boundaries: ?

129,660,128,120 STRAND - (120|128)
 
(ARAFQ(149)|(150)VWSDV)
149,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

149,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
149,660,221,110 REGION - Collagenase-like 1. (110|221)
 
(LRFSR(161)|(162)IHDGE)
161,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

161,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
161,660,221,110 REGION - Collagenase-like 1. (110|221)

Affected feature boundaries: ?

161,660,161,158 STRAND - (158|161)
 
(GLLAH(193)|(194)AFAPG)
193,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

193,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
193,660,221,110 REGION - Collagenase-like 1. (110|221)

Affected feature boundaries: ?

193,660,193,193 METAL - Zinc 1 (By similarity). (193|193)
193,660,193,193 METAL - Zinc 1 (By similarity). (193|193)
 
(HAFAP(197)|(198)GTGVG)
197,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

197,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
197,660,221,110 REGION - Collagenase-like 1. (110|221)

Affected feature boundaries: ?

197,660,199,197 STRAND - (197|199)
 
(GVGGD(204)|(205)SHFDD)
204,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

204,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
204,660,221,110 REGION - Collagenase-like 1. (110|221)

Affected feature boundaries: ?

204,660,203,200 TURN - (200|203)
204,660,204,204 METAL - Calcium 2 (By similarity). (204|204)
204,660,204,204 METAL - Calcium 2 (By similarity). (204|204)
204,660,208,205 STRAND - (205|208)
 
(CPETA(336)|(337)MSTVG)
336,660

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Banda MJ Rice A et al.:Neutrophil elastase processing ... (S01.131) unknown yes

Targeted features: ?

336,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
336,660,396,222 REGION - Collagen-binding. (222|396)
 
(TFLGN(358)|(359)KYESC)
358,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

358,660,375,349 DISULFID - By similarity. (349|375)
358,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
358,660,396,222 REGION - Collagen-binding. (222|396)
358,660,392,344 DOMAIN - Fibronectin type-II 3. (344|392)

Affected feature boundaries: ?

358,660,362,358 STRAND - (358|362)
 
(FLGNK(359)|(360)YESCT)
359,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

359,660,375,349 DISULFID - By similarity. (349|375)
359,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
359,660,396,222 REGION - Collagen-binding. (222|396)
359,660,392,344 DOMAIN - Fibronectin type-II 3. (344|392)
 
(CATTA(379)|(380)NYDDD)
379,660

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Banda MJ Rice A et al.:Neutrophil elastase processing ... (S01.131) unknown yes

Targeted features: ?

379,660,390,363 DISULFID - By similarity. (363|390)
379,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
379,660,396,222 REGION - Collagen-binding. (222|396)
379,660,392,344 DOMAIN - Fibronectin type-II 3. (344|392)

Affected feature boundaries: ?

379,660,379,374 STRAND - (374|379)
 
(TLGPV(464)|(465)TPEIC)
464,660

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Banda MJ Rice A et al.:Neutrophil elastase processing ... (S01.131) unknown yes

Targeted features: ?

464,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
464,660,660,445 CHAIN - PEX. (445|660)
464,660,660,414 REGION - Required for inhibitor TIMP2 binding. (414|660)
 
(TPEIC(469)|(470)KQDIV)
469,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

469,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
469,660,660,445 CHAIN - PEX. (445|660)
469,660,660,414 REGION - Required for inhibitor TIMP2 binding. (414|660)

Affected feature boundaries: ?

469,660,660,469 DISULFID - (469|660)
 
(SKNKK(579)|(580)TYIFA)
579,660

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown yes

Targeted features: ?

579,660,660,469 DISULFID - (469|660)
579,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
579,660,660,445 CHAIN - PEX. (445|660)
579,660,660,414 REGION - Required for inhibitor TIMP2 binding. (414|660)
579,660,613,565 REPEAT - Hemopexin 3. (565|613)

Affected feature boundaries: ?

579,660,584,580 STRAND - (580|584)
 
unknown-30APSPII...
30,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

30,660,109,30 PROPEP - Activation peptide. (30|109)
 
unknown-67LFVLKD...
67,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21518 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21862 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt136618 indirect unknown (unknown)

Affected feature boundaries: ?

67,660,80,67 HELIX - (67|80)
 
unknown-77MQKFFG...
77,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt81295 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt103990 indirect unknown (unknown)
 
unknown-89LDQNTI...
89,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22562 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt136399 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt138232 indirect unknown (unknown)
 
unknown-99KPRCGN...
99,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC31922 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt137083 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt139102 indirect unknown (unknown)
 
unknown-102CGNPDV...
102,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC27138 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26991 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27290 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26582 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26846 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9718 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt137230 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt139306 indirect unknown (unknown)

Affected feature boundaries: ?

102,660,102,102 METAL - Zinc 2; in inhibited form (By similarity). (102|102)
 
unknown-110YNFFPR...
110,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21520 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC22565 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21864 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt115876 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt115875 indirect unknown (unknown)

Affected feature boundaries: ?

110,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
110,660,221,110 REGION - Collagenase-like 1. (110|221)
 
unknown-130GYTPDL...
130,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22568 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt139448 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt141286 indirect unknown (unknown)
 
unknown-150VWSDVT...
150,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22571 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt140872 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt142389 indirect unknown (unknown)
 
unknown-162IHDGEA...
162,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22574 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt141625 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt143046 indirect unknown (unknown)
 
unknown-194AFAPGT...
194,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22577 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt143352 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt144482 indirect unknown (unknown)
 
unknown-198GTGVGG...
198,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22580 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt143556 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt144630 indirect unknown (unknown)
 
unknown-205SHFDDD...
205,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22583 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt143843 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt144943 indirect unknown (unknown)

Affected feature boundaries: ?

205,660,208,205 STRAND - (205|208)
 
unknown-337MSTVGG...
337,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9305 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt148836 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149511 indirect unknown (unknown)
 
unknown-359KYESCT...
359,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22586 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149413 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt150098 indirect unknown (unknown)
 
unknown-360YESCTS...
360,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22589 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149444 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt150114 indirect unknown (unknown)
 
unknown-380NYDDDR...
380,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9308 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149974 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt150527 indirect unknown (unknown)
 
unknown-445YGASPD...
445,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt116212 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt116211 indirect unknown (unknown)

Affected feature boundaries: ?

445,660,660,445 CHAIN - PEX. (445|660)
 
unknown-465TPEICK...
465,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9311 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt151818 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt152248 indirect unknown (unknown)
 
unknown-470KQDIVF...
470,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22592 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt151905 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt152331 indirect unknown (unknown)
 
unknown-580TYIFAG...
580,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22595 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt153449 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt153750 indirect unknown (unknown)

Affected feature boundaries: ?

580,660,584,580 STRAND - (580|584)
 

Protein C-Termini [export]

...KESCN66-unknown
66,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21518 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21862 indirect unknown (unknown)
 
...PQTGD88-unknown
88,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22562 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt121263 indirect unknown (unknown)

Affected feature boundaries: ?

88,660,88,86 STRAND - (86|88)
 
...IETMR98-unknown
98,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC31922 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt119945 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt122173 indirect unknown (unknown)
 
...MRKPR101-unknown
101,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC27138 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26991 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27290 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26582 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26846 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9718 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt120148 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt122381 indirect unknown (unknown)

Affected feature boundaries: ?

101,660,101,101 VARIANT - R -> H (in MONA). (101|101)
 
...PDVAN109-unknown
109,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21520 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC22565 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21864 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt120851 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt122978 indirect unknown (unknown)

Affected feature boundaries: ?

109,660,109,30 PROPEP - Activation peptide. (30|109)
 
...TYRII129-unknown
129,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22568 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt122535 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt124449 indirect unknown (unknown)
 
...ARAFQ149-unknown
149,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22571 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt124012 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt125581 indirect unknown (unknown)
 
...LRFSR161-unknown
161,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22574 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt124804 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt126266 indirect unknown (unknown)

Affected feature boundaries: ?

161,660,161,158 STRAND - (158|161)
 
...GLLAH193-unknown
193,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22577 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt126584 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt127747 indirect unknown (unknown)

Affected feature boundaries: ?

193,660,193,193 METAL - Zinc 1 (By similarity). (193|193)
 
...HAFAP197-unknown
197,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22580 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt126796 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt127897 indirect unknown (unknown)
 
...GVGGD204-unknown
204,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22583 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt127087 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt128219 indirect unknown (unknown)

Affected feature boundaries: ?

204,660,204,204 METAL - Calcium 2 (By similarity). (204|204)
 
...CPETA336-unknown
336,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9305 indirect unknown (unknown)
 
...TFLGN358-unknown
358,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22586 indirect unknown (unknown)
 
...FLGNK359-unknown
359,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22589 indirect unknown (unknown)
 
...CATTA379-unknown
379,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9308 indirect unknown (unknown)

Affected feature boundaries: ?

379,660,379,374 STRAND - (374|379)
 
...TLGPV464-unknown
464,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9311 indirect unknown (unknown)
 
...TPEIC469-unknown
469,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22592 indirect unknown (unknown)
 
...SKNKK579-unknown
579,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22595 indirect unknown (unknown)
 
...DWLGC660-unknown
660,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt76913 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt76914 indirect unknown (unknown)

Affected feature boundaries: ?

660,660,660,469 DISULFID - (469|660)
660,660,660,110 CHAIN - 72 kDa type IV collagenase. (110|660)
660,660,660,445 CHAIN - PEX. (445|660)
660,660,660,414 REGION - Required for inhibitor TIMP2 binding. (414|660)
660,660,660,614 REPEAT - Hemopexin 4. (614|660)
 
4 (MKAS.|.AALL)
4,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
27 (QPVG.|.INTS)
27,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM McQuibban GA et al.:Matrix metalloproteinase proces... (M10.013) unknown yes
 
4 (MKVS.|.EAAL)
4,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
7 (SEAA.|.LSLL)
7,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
77 (EVCT.|.NPND)
77,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
4 (MKVS.|.AVLL)
4,98

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
9 (VLLC.|.LLLM)
9,98

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
74 (KEIC.|.ADPK)
74,98

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
5 (KLCV.|.TVLS)
5,92

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
6 (LCVT.|.VLSL)
6,92

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
44 (RKLP.|.RNFV)
44,92

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
9 (ALLW.|.LLLI)
9,97

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
10 (ALSC.|.LMLV)
10,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
16 (LVTA.|.LGSQ)
16,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
25 (RVTK.|.DAET)
25,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
27 (TKDA.|.ETEF)
27,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
12 ()
12,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22562 indirect unknown
 
33 ()
33,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22565 indirect unknown
 
53 ()
53,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22568 indirect unknown
 
73 ()
73,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22571 indirect unknown
 
85 ()
85,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22574 indirect unknown
 
117 ()
117,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22577 indirect unknown
 
121 ()
121,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22580 indirect unknown
 
128 ()
128,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22583 indirect unknown
 
282 ()
282,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22586 indirect unknown
 
283 ()
283,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22589 indirect unknown
 
393 ()
393,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22592 indirect unknown
 
503 ()
503,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22595 indirect unknown
 
13 (CLML.|.VAVL)
13,113

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
24 (AQFI.|.NDAE)
24,113

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
26 (FIND.|.AETE)
26,113

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
27 (INDA.|.ETEL)
27,113

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012A direct unknown
 
15 ()
15,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22157 indirect unknown
 
33 ()
33,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22163 indirect unknown
 
44 ()
44,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22169 indirect unknown
 
91 ()
91,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22175 indirect unknown
 
93 ()
93,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22180 indirect unknown
 
97 ()
97,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22185 indirect unknown
 
123 ()
123,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22196 indirect unknown
 
142 ()
142,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22201 indirect unknown
 
15 ()
15,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22157 indirect unknown
 
33 ()
33,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22163 indirect unknown
 
44 ()
44,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22169 indirect unknown
 
91 ()
91,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22175 indirect unknown
 
93 ()
93,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22180 indirect unknown
 
97 ()
97,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22185 indirect unknown
 
109 ()
109,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22190 indirect unknown
 
111 ()
111,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22193 indirect unknown
 
134 ()
134,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22196 indirect unknown
 
153 ()
153,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22201 indirect unknown
 
15 ()
15,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22157 indirect unknown
 
33 ()
33,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC22163 indirect unknown
 
44 ()
44,186