P16599: Tumor necrosis factor (Rat)

Protein names
  • Tumor necrosis factor
  • Cachectin
  • TNF-alpha
  • TNFA
  • Tumor necrosis factor ligand superfamily member 2
Gene names Tnf (Tnfa, Tnfsf2)
Organism Rattus norvegicus
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 20

Sequence

        10         20         30         40         50         60 
MSTESMIRDV ELAEEALPKK MGGLQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPNK 
        70         80         90        100        110        120 
EEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ AEEQLEWLSQ RANALLANGM 
       130        140        150        160        170        180 
DLKDNQLVVP ADGLYLIYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVS LLSAIKSPCP 
       190        200        210        220        230    
KDTPEGAELK PWYEPMYLGG VFQLEKGDLL SAEVNLPKYL DITESGQVYF GVIAL

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
Chains:
 
 
    
 
N-termini:

NN
NN
 
C-termini:

CC
CC
 
Features:
     
 
Sequence variations:
     
 
Topology:
   
 
Modifications:
   
 
unknown-1MSTESM...
1,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,235,235,1 CHAIN - Tumor necrosis factor, membrane form. (1|235)
1,235,39,1 CHAIN - Intracellular domain 1. {ECO:0000250}. (1|39)
1,235,35,1 CHAIN - Intracellular domain 2. {ECO:0000250}. (1|35)
1,235,35,1 TOPO_DOM - Cytoplasmic. {ECO:0000255}. (1|35)
 
unknown-50LLNFGV...
50,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

50,235,0,50 CHAIN - C-domain 1. {ECO:0000250}. (50|0)
 
unknown-52NFGVIG...
52,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

52,235,0,52 CHAIN - C-domain 2. {ECO:0000250}. (52|0)
 
unknown-80LRSSSQ...
80,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

80,235,235,80 CHAIN - Tumor necrosis factor, soluble form. (80|235)
 

Protein C-Termini [export]

...GVIAL0-unknown
0,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,235,0,50 CHAIN - C-domain 1. {ECO:0000250}. (50|0)
0,235,0,52 CHAIN - C-domain 2. {ECO:0000250}. (52|0)
 
...LCLSL35-unknown
35,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

35,235,35,1 CHAIN - Intracellular domain 2. {ECO:0000250}. (1|35)
35,235,35,34 SITE - Cleavage; by SPPL2A or SPPL2B. {ECO:0000250}. (34|35)
35,235,35,1 TOPO_DOM - Cytoplasmic. {ECO:0000255}. (1|35)
 
...LFSFL39-unknown
39,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

39,235,39,1 CHAIN - Intracellular domain 1. {ECO:0000250}. (1|39)
39,235,39,39 CONFLICT - L -> P (in Ref. 2; CAA05290/CAA47146). {ECO:0000305}. (39|39)
 
...GVIAL235-unknown
235,235

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

235,235,235,1 CHAIN - Tumor necrosis factor, membrane form. (1|235)
235,235,235,80 CHAIN - Tumor necrosis factor, soluble form. (80|235)
235,235,235,57 TOPO_DOM - Extracellular. {ECO:0000255}. (57|235)
 
Filter by evidence: ?

Directness ?

  • unknown

Physiological relevance ?

  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?