P19137: Laminin subunit alpha-1 (Mouse)

Protein names
  • Laminin subunit alpha-1
  • Laminin A chain
  • Laminin-1 subunit alpha
  • Laminin-3 subunit alpha
  • S-laminin subunit alpha Short=S-LAM alpha
  • LAMA1
Gene names Lama1 (Lama, Lama-1)
Organism Mus musculus
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome (Not Available)

Sequence

        10         20         30         40         50         60 
MRGSGTGAAL LVLLASVLWV TVRSQQRGLF PAILNLATNA HISANATCGE KGPEMFCKLV 
        70         80         90        100        110        120 
EHVPGRPVRH AQCRVCDGNS TNPRERHPIS HAIDGTNNWW QSPSIQNGRE YHWVTVTLDL 
       130        140        150        160        170        180 
RQVFQVAYII IKAANAPRPG NWILERSVDG VKFKPWQYYA VSDTECLTRY KITPRRGPPT 
       190        200        210        220        230        240 
YRADNEVICT SYYSKLVPLE HGEIHTSLIN GRPSADDPSP QLLEFTSARY IRLRLQRIRT 
       250        260        270        280        290        300 
LNADLMTLSH RDLRDLDPIV TRRYYYSIKD ISVGGMCICY GHASSCPWDE EAKQLQCQCE 
       310        320        330        340        350        360 
HNTCGESCDR CCPGYHQQPW RPGTISSGNE CEECNCHNKA KDCYYDSSVA KERRSLNTAG 
       370        380        390        400        410        420 
QYSGGGVCVN CSQNTTGINC ETCIDQYYRP HKVSPYDDHP CRPCNCDPVG SLSSVCIKDD 
       430        440        450        460        470        480 
RHADLANGKW PGQCPCRKGY AGDKCDRCQF GYRGFPNCIP CDCRTVGSLN EDPCIEPCLC 
       490        500        510        520        530        540 
KKNVEGKNCD RCKPGFYNLK ERNPEGCSEC FCFGVSGVCD SLTWSISQVT NMSGWLVTDL 
       550        560        570        580        590        600 
MSTNKIRSQQ DVLGGHRQIS INNTAVMQRL TSTYYWAAPE AYLGNKLTAF GGFLKYTVSY 
       610        620        630        640        650        660 
DIPVETVDSD LMSHADIIIK GNGLTISTRA EGLSLQPYEE YFNVVRLVPE NFRDFNTRRE 
       670        680        690        700        710        720 
IDRDQLMTVL ANVTHLLIRA NYNSAKMALY RLDSVSLDIA SPNAIDLAVA ADVEHCECPQ 
       730        740        750        760        770        780 
GYTGTSCEAC LPGYYRVDGI LFGGICQPCE CHGHASECDI HGICSVCTHN TTGDHCEQCL 
       790        800        810        820        830        840 
PGFYGTPSRG TPGDCQPCAC PLSIDSNNFS PTCHLTDGEE VVCDQCAPGY SGSWCERCAD 
       850        860        870        880        890        900 
GYYGNPTVPG GTCVPCNCSG NVDPLEAGHC DSVTGECLKC LWNTDGAHCE RCADGFYGDA 
       910        920        930        940        950        960 
VTAKNCRACD CHENGSLSGV CHLETGLCDC KPHVTGQQCD QCLSGYYGLD TGLGCVPCNC 
       970        980        990       1000       1010       1020 
SVEGSVSDNC TEEGQCHCGP GVSGKQCDRC SHGFYAFQDG GCTPCDCAHT QNNCDPASGE 
      1030       1040       1050       1060       1070       1080 
CLCPPHTQGL KCEECEEAYW GLDPEQGCQA CNCSAVGSTS AQCDVLSGHC PCKKGFGGQS 
      1090       1100       1110       1120       1130       1140 
CHQCSLGYRS FPDCVPCGCD LRGTLPDTCD LEQGLCSCSE DSGTCSCKEN VVGPQCSKCQ 
      1150       1160       1170       1180       1190       1200 
AGTFALRGDN PQGCSPCFCF GLSQLCSELE GYVRTLITLA SDQPLLHVVS QSNLKGTIEG 
      1210       1220       1230       1240       1250       1260 
VHFQPPDTLL DAEAVRQHIY AEPFYWRLPK QFQGDQLLAY GGKLQYSVAF YSTLGTGTSN 
      1270       1280       1290       1300       1310       1320 
YEPQVLIKGG RARKHVIYMD APAPENGVRQ DYEVQMKEEF WKYFNSVSEK HVTHSDFMSV 
      1330       1340       1350       1360       1370       1380 
LSNIDYILIK ASYGQGLQQS RIANISMEVG RKAVELPAEG EAALLLELCV CPPGTAGHSC 
      1390       1400       1410       1420       1430       1440 
QDCAPGYYRE KLPESGGRGP RPLLAPCVPC NCNNHSDVCD PETGKCLSCR DHTSGDHCEL 
      1450       1460       1470       1480       1490       1500 
CASGYYGKVT GLPGDCTPCT CPHHPPFSFS PTCVVEGDSD FRCNACLPGY EGQYCERCSA 
      1510       1520       1530       1540       1550       1560 
GYHGNPRAAG GSCQTCDCNP QGSVHSDCDR ASGQCVCKPG ATGLHCEKCL PRHILMESDC 
      1570       1580       1590       1600       1610       1620 
VSCDDDCVGP LLNDLDSVGD AVLSLNLTGV SPAPYGILEN LENTTKYFQR YLIKENAKKI 
      1630       1640       1650       1660       1670       1680 
RAEIQLEGIA EQTENLQKEL TRVLARHQKV NAEMERTSNG TQALATFIEQ LHANIKEITE 
      1690       1700       1710       1720       1730       1740 
KVATLNQTAR KDFQPPVSAL QSMHQNISSL LGLIKERNFT EMQQNATLEL KAAKDLLSRI 
      1750       1760       1770       1780       1790       1800 
QKRFQKPQEK LKALKEANSL LSNHSEKLQA AEELLKEAGS KTQESNLLLL LVKANLKEEF 
      1810       1820       1830       1840       1850       1860 
QEKKLRVQEE QNVTSELIAK GREWVDAAGT HTAAAQDTLT QLEHHRDELL LWARKIRSHV 
      1870       1880       1890       1900       1910       1920 
DDLVMQMSKR RARDLVHRAE QHASELQSRA GALDRDLENV RNVSLNATSA AHVHSNIQTL 
      1930       1940       1950       1960       1970       1980 
TEEAEMLAAD AHKTANKTDL ISESLASRGK AVLQRSSRFL KESVGTRRKQ QGITMKLDEL 
      1990       2000       2010       2020       2030       2040 
KNLTSQFQES VDNITKQAND SLAMLRESPG GMREKGRKAR ELAAAANESA VKTLEDVLAL 
      2050       2060       2070       2080       2090       2100 
SLRVFNTSED LSRVNATVQE TNDLLHNSTM TTLLAGRKMK DMEMQANLLL DRLKPLKTLE 
      2110       2120       2130       2140       2150       2160 
ENLSRNLSEI KLLISRARKQ AASIKVAVSA DRDCIRAYQP QTSSTNYNTL ILNVKTQEPD 
      2170       2180       2190       2200       2210       2220 
NLLFYLGSSS SSDFLAVEMR RGKVAFLWDL GSGSTRLEFP EVSINNNRWH SIYITRFGNM 
      2230       2240       2250       2260       2270       2280 
GSLSVKEASA AENPPVRTSK SPGPSKVLDI NNSTLMFVGG LGGQIKKSPA VKVTHFKGCM 
      2290       2300       2310       2320       2330       2340 
GEAFLNGKSI GLWNYIEREG KCNGCFGSSQ NEDSSFHFDG SGYAMVEKTL RPTVTQIVIL 
      2350       2360       2370       2380       2390       2400 
FSTFSPNGLL FYLASNGTKD FLSIELVRGR VKVMVDLGSG PLTLMTDRRY NNGTWYKIAF 
      2410       2420       2430       2440       2450       2460 
QRNRKQGLLA VFDAYDTSDK ETKQGETPGA ASDLNRLEKD LIYVGGLPHS KAVRKGVSSR 
      2470       2480       2490       2500       2510       2520 
SYVGCIKNLE ISRSTFDLLR NSYGVRKGCA LEPIQSVSFL RGGYVEMPPK SLSPESSLLA 
      2530       2540       2550       2560       2570       2580 
TFATKNSSGI LLVALGKDAE EAGGAQAHVP FFSIMLLEGR IEVHVNSGDG TSLRKALLHA 
      2590       2600       2610       2620       2630       2640 
PTGSYSDGQE HSISLVRNRR VITIQVDENS PVEMKLGPLT EGKTIDISNL YIGGLPEDKA 
      2650       2660       2670       2680       2690       2700 
TPMLKMRTSF HGCIKNVVLD AQLLDFTHAT GSEQVELDTC LLAEEPMQSL HREHGELPPE 
      2710       2720       2730       2740       2750       2760 
PPTLPQPELC AVDTAPGYVA GAHQFGLSQN SHLVLPLNQS DVRKRLQVQL SIRTFASSGL 
      2770       2780       2790       2800       2810       2820 
IYYVAHQNQM DYATLQLQEG RLHFMFDLGK GRTKVSHPAL LSDGKWHTVK TEYIKRKAFM 
      2830       2840       2850       2860       2870       2880 
TVDGQESPSV TVVGNATTLD VERKLYLGGL PSHYRARNIG TITHSIPACI GEIMVNGQQL 
      2890       2900       2910       2920       2930       2940 
DKDRPLSASA VDRCYVVAQE GTFFEGSGYA ALVKEGYKVR LDLNITLEFR TTSKNGVLLG 
      2950       2960       2970       2980       2990       3000 
ISSAKVDAIG LEIVDGKVLF HVNNGAGRIT ATYQPRAARA LCDGKWHTLQ AHKSKHRIVL 
      3010       3020       3030       3040       3050       3060 
TVDGNSVRAE SPHTHSTSAD TNDPIYVGGY PAHIKQNCLS SRASFRGCVR NLRLSRGSQV 
      3070       3080    
QSLDLSRAFD LQGVFPHSCP GPEP

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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Chains:
 
 
N-termini:
NNNNN
 
C-termini:
CCCCC
 
Cleavage sites:
    
 
 
Sequence variations:
 
 
Modifications:
 
 
(ELQSR(1889)|(1890)AGALD)
1889,3084

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMA1_MOUSE @1889 unknown yes

Targeted features: ?

1889,3084,1903,1869 COILED - Potential. (1869|1903)
1889,3084,3084,25 CHAIN - Laminin subunit alpha-1. (25|3084)
1889,3084,2124,1564 REGION - Domain II and I. (1564|2124)
 
(GNMGS(2222)|(2223)LSVKE)
2222,3084

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP2_MOUSE -> LAMA1_MOUSE @2222 unknown yes

Targeted features: ?

2222,3084,2305,2125 DOMAIN - Laminin G-like 1. (2125|2305)
2222,3084,3084,25 CHAIN - Laminin subunit alpha-1. (25|3084)
 
(GRVKV(2373)|(2374)MVDLG)
2373,3084

Neutrophil elastase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ELNE_MOUSE -> LAMA1_MOUSE @2373 unknown yes

Targeted features: ?

2373,3084,2489,2313 DOMAIN - Laminin G-like 2. (2313|2489)
2373,3084,3084,25 CHAIN - Laminin subunit alpha-1. (25|3084)
 
(HAPTG(2583)|(2584)SYSDG)
2583,3084

Matrix metalloproteinase-9 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP9_MOUSE -> LAMA1_MOUSE @2583 unknown yes

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP2_MOUSE -> LAMA1_MOUSE @2583 unknown yes

Targeted features: ?

2583,3084,2680,2494 DOMAIN - Laminin G-like 3. (2494|2680)
2583,3084,3084,25 CHAIN - Laminin subunit alpha-1. (25|3084)
 
pyrrolidone carboxylic acid-25QQRGLF...
25,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

25,3084,25,25 MOD_RES - Pyrrolidone carboxylic acid. (25|25)
25,3084,276,25 DOMAIN - Laminin N-terminal. (25|276)
25,3084,3084,25 CHAIN - Laminin subunit alpha-1. (25|3084)
 
unknown-1890AGALDR...
1890,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32187 indirect unknown (unknown)
 
unknown-2223LSVKEA...
2223,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33425 indirect unknown (unknown)
 
unknown-2374MVDLGS...
2374,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32188 indirect unknown (unknown)
 
unknown-2584SYSDGQ...
2584,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34623 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC33426 indirect unknown (unknown)
 

Protein C-Termini [export]

...ELQSR1889-unknown
1889,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32187 indirect unknown (unknown)
 
...GNMGS2222-unknown
2222,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33425 indirect unknown (unknown)
 
...GRVKV2373-unknown
2373,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC32188 indirect unknown (unknown)
 
...HAPTG2583-unknown
2583,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34623 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC33426 indirect unknown (unknown)
 
...PGPEP3084-unknown
3084,3084

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

3084,3084,3084,25 CHAIN - Laminin subunit alpha-1. (25|3084)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?