P21754: Zona pellucida sperm-binding protein 3 (Human)

Protein names
  • Zona pellucida sperm-binding protein 3
  • Sperm receptor
  • ZP3A/ZP3B
  • Zona pellucida glycoprotein 3 Short=Zp-3
  • Zona pellucida protein C
  • ZP3
Gene names ZP3 (ZP3A, ZP3B)
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 7

Isoforms

  • Isoform ZP3B of Zona pellucida sperm-binding protein 3 (P21754-2): sequence view | extended view
  • Isoform 3 of Zona pellucida sperm-binding protein 3 (P21754-3): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF 
        70         80         90        100        110        120 
GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP 
       130        140        150        160        170        180 
RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN 
       190        200        210        220        230        240 
WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL 
       250        260        270        280        290        300 
VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC 
       310        320        330        340        350        360 
SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV 
       370        380        390        400        410        420 
TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV 
   
SASE

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
Chains:
 
 
 
N-termini:

NNNN
 
C-termini:

CC
CC
 
Cleavage sites:
 
 
 
 
 
 
 
Features:
   
 
Sequence variations:
 
      
 
Topology:
   
 
Modifications:
 
 
(SRNRR(352)|(353)HVTEE)
352,424

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Saling P Kiefer SM et al.:Proteolytic processing of human... (S08.071) unknown none

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Targeted features: ?

352,424,387,23 TOPO_DOM - Extracellular (Potential). (23|387)
 
unknown-1MELSYR...
1,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt95662 indirect unknown (unknown)

Affected feature boundaries: ?

1,424,51,1 VAR_SEQ - Missing (in isoform 3). (1|51)
1,424,22,1 SIGNAL - (1|22)
 
pyrrolidone carboxylic acid-23QPLWLL...
23,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt113250 indirect unknown (unknown)

Affected feature boundaries: ?

23,424,387,23 TOPO_DOM - Extracellular (Potential). (23|387)
23,424,350,23 CHAIN - Zona pellucida sperm-binding protein 3. (23|350)
23,424,0,23 CHAIN - Processed zona pellucida sperm-binding protein 3. (23|0)
23,424,23,23 MOD_RES - Pyrrolidone carboxylic acid. (23|23)
 
unknown-52MVMVSK...
52,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt95663 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt105685 indirect unknown (unknown)
 
unknown-353HVTEEA...
353,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9745 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27166 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27019 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27318 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26605 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26874 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149912 indirect unknown (unknown)
 

Protein C-Termini [export]

...VSASE0-unknown
0,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,424,0,23 CHAIN - Processed zona pellucida sperm-binding protein 3. (23|0)
 
...SASRN350-unknown
350,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

350,424,350,23 CHAIN - Zona pellucida sperm-binding protein 3. (23|350)
 
...SRNRR352-unknown
352,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9745 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27166 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27019 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27318 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26605 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26874 indirect unknown (unknown)
 
...VSASE424-unknown
424,424

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TCt91281 indirect unknown (unknown)

Affected feature boundaries: ?

424,424,424,409 TOPO_DOM - Cytoplasmic (Potential). (409|424)
424,424,424,373 VAR_SEQ - Missing (in isoform ZP3B). (373|424)
424,424,424,351 PROPEP - Removed in mature form (By similarity). (351|424)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • none
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?