P24347: Stromelysin-3 (Human)

Protein names
  • Stromelysin-3 (SL-3)
  • Matrix metalloproteinase-11 Short=MMP-11 (SL-3)
  • MMP11
Gene names MMP11 (STMY3)
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.007 (MEROPS)
Chromosome 22

Sequence

        10         20         30         40         50         60 
MAPAAWLRSA AARALLPPML LLLLQPPPLL ARALPPDAHH LHAERRGPQP WHAALPSSPA 
        70         80         90        100        110        120 
PAPATQEAPR PASSLRPPRC GVPDPSDGLS ARNRQKRFVL SGGRWEKTDL TYRILRFPWQ 
       130        140        150        160        170        180 
LVQEQVRQTM AEALKVWSDV TPLTFTEVHE GRADIMIDFA RYWHGDDLPF DGPGGILAHA 
       190        200        210        220        230        240 
FFPKTHREGD VHFDYDETWT IGDDQGTDLL QVAAHEFGHV LGLQHTTAAK ALMSAFYTFR 
       250        260        270        280        290        300 
YPLSLSPDDC RGVQHLYGQP WPTVTSRTPA LGPQAGIDTN EIAPLEPDAP PDACEASFDA 
       310        320        330        340        350        360 
VSTIRGELFF FKAGFVWRLR GGQLQPGYPA LASRHWQGLP SPVDAAFEDA QGHIWFFQGA 
       370        380        390        400        410        420 
QYWVYDGEKP VLGPAPLTEL GLVRFPVHAA LVWGPEKNKI YFFRGRDYWR FHPSTRRVDS 
       430        440        450        460        470        480 
PVPRRATDWR GVPSEIDAAF QDADGYAYFL RGRLYWKFDP VKVKALEGFP RLVGPDFFGC 
   
AEPANTFL

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
Chains:
 
 
N-termini:
NNNN
 
C-termini:
CCCC
 
Cleavage sites:
 
 
 
 
   
 
Features:
  
 
 
Binding & active sites:
            
 
Sequence variations:
      
 
Topology:
    
 
(NRQKR(97)|(98)FVLSG)
97,488

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Pei D et al.:Furin-dependent intracellular a... (S08.071) unknown yes

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Affected feature boundaries: ?

97,488,488,98 CHAIN - Stromelysin-3. (98|488)
97,488,97,32 PROPEP - Activation peptide (By similarity). (32|97)
 
(NEIAP(284)|(285)LEPDA)
284,488

Stromelysin-3 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> MMP11_HUMAN @284 unknown none

Targeted features: ?

284,488,488,98 CHAIN - Stromelysin-3. (98|488)
 
(EIDAA(439)|(440)FQDAD)
439,488

Stromelysin-3 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> MMP11_HUMAN @439 unknown none

Targeted features: ?

439,488,480,294 DISULFID - By similarity. (294|480)
439,488,488,98 CHAIN - Stromelysin-3. (98|488)
439,488,480,433 REPEAT - Hemopexin 4. (433|480)
 
unknown-32RALPPD...
32,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

32,488,97,32 PROPEP - Activation peptide (By similarity). (32|97)
 
unknown-98FVLSGG...
98,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26890 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9760 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27035 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27334 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26620 indirect unknown (unknown)

Affected feature boundaries: ?

98,488,488,98 CHAIN - Stromelysin-3. (98|488)
 
unknown-285LEPDAP...
285,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19963 indirect unknown (unknown)
 
unknown-440FQDADG...
440,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19964 indirect unknown (unknown)
 

Protein C-Termini [export]

...NRQKR97-unknown
97,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26890 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9760 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27035 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27334 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26620 indirect unknown (unknown)

Affected feature boundaries: ?

97,488,97,32 PROPEP - Activation peptide (By similarity). (32|97)
 
...NEIAP284-unknown
284,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19963 indirect unknown (unknown)
 
...EIDAA439-unknown
439,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19964 indirect unknown (unknown)
 
...ANTFL488-unknown
488,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

488,488,488,98 CHAIN - Stromelysin-3. (98|488)
 
7 (PTVF.|.FDIA)
7,165

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> PPIA_HUMAN @7 unknown none
 
7 (DAGE.|.FVDL)
7,83

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> RS21_HUMAN @7 unknown none
 
19 (VAQN.|.YINY)
19,222

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> LXN_HUMAN @19 unknown none
 
62 (PPAA.|.IESP)
62,205

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> HSPB1_HUMAN @62 unknown none
 
91 ()
91,274

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19958 indirect unknown
 
106 (HPTL.|.LTEA)
106,377

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> ACTA_HUMAN @106 unknown none
 
237 (SSSS.|.LEKS)
237,377

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> ACTA_HUMAN @237 unknown none
 
165 (KALH.|.VTNI)
165,259

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Martinez-A C Manes S et al.:Identification of insulin-like ... (M10.007) unknown yes
 
233 ()
233,416

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19958 indirect unknown
 
266 (HSPA.|.FQHP)
266,449

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> CLUS_HUMAN @266 unknown none
 
277 ()
277,460

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19958 indirect unknown
 
284 (EIAP.|.LEPD)
284,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> MMP11_HUMAN @284 unknown none
 
439 (IDAA.|.FQDA)
439,488

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> MMP11_HUMAN @439 unknown none
 
296 (LYAN.|.TVLS)
296,375

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> ACTB_HUMAN @296 unknown none
 
305 (PNVH.|.GALA)
305,531

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> PTBP1_HUMAN @305 unknown none
 
311 ()
311,362

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19967 indirect unknown
 
312 (PQMN.|.YIQV)
312,363

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> RD23A_HUMAN @312 unknown none
 
318 ()
318,501

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19958 indirect unknown
 
331 ()
331,427

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19953 indirect unknown
 
333 ()
333,427

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19955 indirect unknown
 
374 (AAGA.|.MFLE)
374,418

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Pei D et al.:Hydrolytic inactivation of a br... (M10.007) unknown yes
 
395 (EAAA.|.ATSI)
395,491

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Pei D et al.:Hydrolytic inactivation of a br... (M10.007) unknown yes
 
397 (AAAT.|.SIAM)
397,491

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Weiss SJ Pei D et al.:Hydrolytic inactivation of a br... (M10.007) unknown yes
 
417 (VAQS.|.YSLG)
417,525

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> STAM2_HUMAN @417 unknown none
 
420 (CEEC.|.IQLE)
420,543

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> STIP1_HUMAN @420 unknown none
 
662 (FETA.|.LLSS)
662,724

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> HS90B_HUMAN @662 unknown none
 
670 (YETA.|.LLSS)
670,732

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP11_HUMAN -> HS90A_HUMAN @670 unknown none
 
792 ()
792,854

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC19950 indirect unknown
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • unknown
  • yes
  • none

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?