P29279: Connective tissue growth factor (Human)

Protein names
  • Connective tissue growth factor
  • CCN family member 2
  • Hypertrophic chondrocyte-specific protein 24
  • Insulin-like growth factor-binding protein 8 Short=IBP-8 Short=IGF-binding protein 8 Short=IGFBP-8
  • CTGF
Gene names CTGF (HCS24, IGFBP8)
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 6

Isoforms

  • Isoform 2 of Connective tissue growth factor (P29279-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 
        70         80         90        100        110        120 
AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 
       130        140        150        160        170        180 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 
       190        200        210        220        230        240 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 
       250        260        270        280        290        300 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 
       310        320        330        340    
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
Chains:
 
 
N-termini:

NNN
N
NN
N
N
 
C-termini:
C
C
CC
C
CC
 
Features:
     
 
 
Sequence variations:
  
 
 
(GPALA(180)|(181)AYRLE)
180,349

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Dean RA et al.:Identification of candidate ang... (M10.003) unknown yes

Targeted features: ?

180,349,198,172 VAR_SEQ - Missing (in isoform 2). (172|198)
180,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
 
(PALAA(181)|(182)YRLED)
181,349

Stromelysin-1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Matrix metalloproteinase-14 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Tam EM et al.:Membrane protease proteomics: I... (M10.014) unknown yes

Disintegrin and metalloproteinase domain-containing protein 28 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224) unknown yes

Matrilysin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Targeted features: ?

181,349,198,172 VAR_SEQ - Missing (in isoform 2). (172|198)
181,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
 
(LAAYR(183)|(184)LEDTF)
183,349

Collagenase 3 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Matrilysin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Targeted features: ?

183,349,198,172 VAR_SEQ - Missing (in isoform 2). (172|198)
183,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
 
(TFGPD(191)|(192)PTMIR)
191,349

Disintegrin and metalloproteinase domain-containing protein 28 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Mochizuki S et al.:ADAM28 is activated by MMP-7 (m... (M12.224) unknown yes

Targeted features: ?

191,349,198,172 VAR_SEQ - Missing (in isoform 2). (172|198)
191,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
 
(PDPTM(194)|(195)IRANC)
194,349

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Stromelysin-1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Collagenase 3 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Matrilysin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Targeted features: ?

194,349,198,172 VAR_SEQ - Missing (in isoform 2). (172|198)
194,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
 
(IRANC(199)|(200)LVQTT)
199,349

Interstitial collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Collagenase 3 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Matrilysin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Hashimoto G et al.:Matrix metalloproteinases cleav... (M10.013) unknown yes

Targeted features: ?

199,349,349,27 CHAIN - Connective tissue growth factor. (27|349)

Affected feature boundaries: ?

199,349,198,172 VAR_SEQ - Missing (in isoform 2). (172|198)
 
unknown-1MTAASM...
1,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt72014 indirect unknown (unknown)

Affected feature boundaries: ?

1,349,26,1 SIGNAL - Potential. (1|26)
 
unknown-27QNCSGP...
27,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt114269 indirect unknown (unknown)

Affected feature boundaries: ?

27,349,98,27 DOMAIN - IGFBP N-terminal. (27|98)
27,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
 
unknown-181AYRLED...
181,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22899 indirect unknown (unknown)
 
unknown-182YRLEDT...
182,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC23899 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21596 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC164 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24760 indirect unknown (unknown)
 
unknown-184LEDTFG...
184,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21400 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24761 indirect unknown (unknown)
 
unknown-192PTMIRA...
192,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC165 indirect unknown (unknown)
 
unknown-195IRANCL...
195,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21763 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC23900 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21401 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24762 indirect unknown (unknown)
 
unknown-200LVQTTE...
200,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21764 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21402 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24763 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt198055 indirect unknown (unknown)
 

Protein C-Termini [export]

...GPALA180-unknown
180,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC22899 indirect unknown (unknown)
 
...PALAA181-unknown
181,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC23899 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21596 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC164 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24760 indirect unknown (unknown)
 
...LAAYR183-unknown
183,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21400 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24761 indirect unknown (unknown)
 
...TFGPD191-unknown
191,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC165 indirect unknown (unknown)
 
...PDPTM194-unknown
194,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21763 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC23900 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21401 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24762 indirect unknown (unknown)
 
...IRANC199-unknown
199,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC21764 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC21402 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC24763 indirect unknown (unknown)
 
...YGDMA349-unknown
349,349

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt67632 indirect unknown (unknown)

Affected feature boundaries: ?

349,349,349,27 CHAIN - Connective tissue growth factor. (27|349)
349,349,349,247 REGION - Heparin-binding. (247|349)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?