P31947: 14-3-3 protein sigma (Human)

Protein names
  • 14-3-3 protein sigma
  • Epithelial cell marker protein 1
  • Stratifin
  • 1433S
Gene names SFN (HME1)
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 1

Isoforms

  • Isoform 2 of 14-3-3 protein sigma (P31947-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 
        70         80         90        100        110        120 
VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY 
       130        140        150        160        170        180 
LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 
       190        200        210        220        230        240 
YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 
   
EAPQEPQS

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
Chains:
 
 
N-termini:

NN
N
NNN
NN
NN
 
C-termini:
C
C
CCC
CC
CCC
C
 
Features:
  
 
Sequence variations:
     
 
Modifications:
  
 
(AERYE(20)|(21)DMAAF)
20,248

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

20,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
 
(EDMAA(24)|(25)FMKGA)
24,248

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

24,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
24,248,31,19 HELIX - (19|31)
 
(DMAAF(25)|(26)MKGAV)
25,248

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

25,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
25,248,31,19 HELIX - (19|31)
 
(WRVLS(63)|(64)SIEQK)
63,248

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

63,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
63,248,69,38 HELIX - (38|69)
 
(EQKSN(70)|(71)EEGSE)
70,248

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

70,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)

Affected feature boundaries: ?

70,248,69,38 HELIX - (38|69)
 
(KSNEE(72)|(73)GSEEK)
72,248

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

72,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
 
(LQGVC(96)|(97)DTVLG)
96,248

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

96,248,116,85 VAR_SEQ - Missing (in isoform 2). (85|116)
96,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
96,248,104,80 HELIX - (80|104)
 
(QGVCD(97)|(98)TVLGL)
97,248

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

97,248,116,85 VAR_SEQ - Missing (in isoform 2). (85|116)
97,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
97,248,104,80 HELIX - (80|104)
 
(VLGLL(103)|(104)DSHLI)
103,248

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

103,248,116,85 VAR_SEQ - Missing (in isoform 2). (85|116)
103,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
 
unknown-1MERASL...
1,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt65721 indirect unknown (unknown)

Affected feature boundaries: ?

1,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
 
unknown-21DMAAFM...
21,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19043 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17583 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt136919 indirect unknown (unknown)
 
unknown-25FMKGAV...
25,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17585 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt137206 indirect unknown (unknown)
 
unknown-26MKGAVE...
26,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17587 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt137287 indirect unknown (unknown)
 
unknown-64SIEQKS...
64,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17589 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt140245 indirect unknown (unknown)
 
unknown-71EEGSEE...
71,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19045 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17591 indirect unknown (unknown)
 
unknown-73GSEEKG...
73,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19047 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17593 indirect unknown (unknown)
 
unknown-97DTVLGL...
97,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19049 indirect unknown (unknown)
 
unknown-98TVLGLL...
98,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19050 indirect unknown (unknown)
 
unknown-104DSHLIK...
104,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19051 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17595 indirect unknown (unknown)
 

Protein C-Termini [export]

...AERYE20-unknown
20,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19043 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17583 indirect unknown (unknown)
 
...EDMAA24-unknown
24,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17585 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt120123 indirect unknown (unknown)
 
...DMAAF25-unknown
25,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17587 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt120219 indirect unknown (unknown)
 
...WRVLS63-unknown
63,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17589 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt123364 indirect unknown (unknown)
 
...EQKSN70-unknown
70,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19045 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17591 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt123859 indirect unknown (unknown)
 
...KSNEE72-unknown
72,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19047 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17593 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt123968 indirect unknown (unknown)
 
...LQGVC96-unknown
96,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19049 indirect unknown (unknown)
 
...QGVCD97-unknown
97,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19050 indirect unknown (unknown)
 
...VLGLL103-unknown
103,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19051 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC17595 indirect unknown (unknown)
 
...QEPQS248-unknown
248,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt61339 indirect unknown (unknown)
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

248,248,248,248 MOD_RES - Phosphoserine. (248|248)
248,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
 
...QEPQS248-unknown
248,248

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

248,248,248,248 MOD_RES - Phosphoserine. (248|248)
248,248,248,1 CHAIN - 14-3-3 protein sigma. (1|248)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect
  • direct

Physiological relevance ?

  • none
  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?