P34960: Macrophage metalloelastase (Mouse)

Protein names
  • Macrophage metalloelastase (MME)
  • Matrix metalloproteinase-12 Short=MMP-12 (MME)
  • MMP12
Gene names Mmp12 (Mme)
Organism Mus musculus
Protease Family M10 (MEROPS)
Protease ID M10.009 (MEROPS)
Chromosome 9

Sequence

        10         20         30         40         50         60 
MSCTLLKGVC TMKFLMMIVF LQVSACGAAP MNDSEFAEWY LSRFYDYGKD RIPMTKTKTN 
        70         80         90        100        110        120 
RNFLKEKLQE MQQFFGLEAT GQLDNSTLAI MHIPRCGVPD VQHLRAVPQR SRWMKRYLTY 
       130        140        150        160        170        180 
RIYNYTPDMK REDVDYIFQK AFQVWSDVTP LRFRKLHKDE ADIMILFAFG AHGDFNYFDG 
       190        200        210        220        230        240 
KGGTLAHAFY PGPGIQGDAH FDEAETWTKS FQGTNLFLVA VHELGHSLGL QHSNNPKSIM 
       250        260        270        280        290        300 
YPTYRYLNPS TFRLSADDIR NIQSLYGAPV KPPSLTKPSS PPSTFCHQSL SFDAVTTVGE 
       310        320        330        340        350        360 
KIFFFKDWFF WWKLPGSPAT NITSISSIWP SIPSGIQAAY EIESRNQLFL FKDEKYWLIN 
       370        380        390        400        410        420 
NLVPEPHYPR SIYSLGFSAS VKKVDAAVFD PLRQKVYFFV DKHYWRYDVR QELMDPAYPK 
       430        440        450        460        470    
LISTHFPGIK PKIDAVLYFK RHYYIFQGAY QLEYDPLFRR VTKTLKSTSW FGC

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
Chains:
 
 
N-termini:
NNNN
N
 
C-termini:
C
C
CC
 
Cleavage sites:
  
 
Features:
  
 
 
Topology:
    
 
(IFQKA(141)|(142)FQVWS)
141,473

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown none

Targeted features: ?

141,473,473,110 CHAIN - Macrophage metalloelastase. (110|473)
 
(QKAFQ(143)|(144)VWSDV)
143,473

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown none

Targeted features: ?

143,473,473,110 CHAIN - Macrophage metalloelastase. (110|473)
 
unknown-29APMNDS...
29,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

29,473,109,29 PROPEP - Activation peptide. (29|109)
 
unknown-71MQQFFG...
71,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSMUSP00000114129 unknown unknown (unknown)
inferred from electronic annotation Ensembl inferred from ensembl protein ENSMUSP00000116080 unknown unknown (unknown)
 
unknown-110RSRWMK...
110,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

110,473,473,110 CHAIN - Macrophage metalloelastase. (110|473)
 
unknown-142FQVWSD...
142,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33537 indirect unknown (unknown)
 
unknown-144VWSDVT...
144,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33538 indirect unknown (unknown)
 

Protein C-Termini [export]

...IFQKA141-unknown
141,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33537 indirect unknown (unknown)
 
...FQKAF142-unknown
142,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSMUSP00000116080 unknown unknown (unknown)
 
...QKAFQ143-unknown
143,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33538 indirect unknown (unknown)
 
...SWFGC473-unknown
473,473

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

473,473,473,430 REPEAT - Hemopexin 4. (430|473)
473,473,473,110 CHAIN - Macrophage metalloelastase. (110|473)
473,473,473,286 DISULFID - By similarity. (286|473)
 
11 ()
11,184

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
96 ()
96,184

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
98 ()
98,184

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
101 ()
101,184

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,128

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
70 ()
70,128

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
72 ()
72,128

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
75 ()
75,128

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,158

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
70 ()
70,158

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
72 ()
72,158

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
75 ()
75,158

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,154

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
96 ()
96,154

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
98 ()
98,154

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
101 ()
101,154

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,169

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
70 ()
70,169

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
72 ()
72,169

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
75 ()
75,169

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
96 ()
96,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
98 ()
98,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
101 ()
101,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,117

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
70 ()
70,117

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
72 ()
72,117

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
75 ()
75,117

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,143

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
96 ()
96,143

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
98 ()
98,143

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
101 ()
101,143

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,176

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
96 ()
96,176

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
98 ()
98,176

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
101 ()
101,176

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
11 ()
11,191

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
70 ()
70,191

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32712 indirect unknown
 
72 ()
72,191

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32723 indirect unknown
 
75 ()
75,191

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32734 indirect unknown
 
75 (DPKN.|.NWQG)
75,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
116 (ESDE.|.LQTI)
116,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
126 (DPTA.|.ASGG)
126,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
144 (SQRS.|.KYLA)
144,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
203 (GSLP.|.QKSQ)
203,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
205 (LPQK.|.SQHG)
205,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
208 (KSQH.|.GRTQ)
208,250

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
75 ()
75,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32694 indirect unknown
 
116 ()
116,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32696 indirect unknown
 
126 ()
126,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32698 indirect unknown
 
144 ()
144,195

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32700 indirect unknown
 
112 (RAFP.|.QGRY)
112,327

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
112 ()
112,222

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC32745 indirect unknown
 
434 (CYSG.|.DENP)
434,1191

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Maisi P Pirila E et al.:Matrix metalloproteinases proce... (M10.009) unknown yes
 
606 (DHAA.|.LTSC)
606,1191

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Maisi P Pirila E et al.:Matrix metalloproteinases proce... (M10.009) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • none
  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?