P38111: Serine/threonine-protein kinase MEC1 (strain ATCC 204508 / S288c) (Baker's yeast)

Protein names
  • Serine/threonine-protein kinase MEC1
  • ATR homolog
  • DNA-damage checkpoint kinase MEC1
  • Mitosis entry checkpoint protein 1
  • ATR
Gene names MEC1 (ESR1, SAD3)
Organism Saccharomyces cerevisiae
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome II

Sequence

        10         20         30         40         50         60 
MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT LIRNLKDQRR 
        70         80         90        100        110        120 
NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ RLIDDFLNIS VLNYDNYHRI 
       130        140        150        160        170        180 
WFMRRKLGSW CKACVEFYGK PAKFQLTAHF ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG 
       190        200        210        220        230        240 
LYILLYWFTS EYSTFGNSIA FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ 
       250        260        270        280        290        300 
LKYISLVVDY VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL 
       310        320        330        340        350        360 
RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL KRRSLPVEAL 
       370        380        390        400        410        420 
KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV LKKFNKTERG TLLKYRVNQL 
       430        440        450        460        470        480 
SPGFFQRAGN DFKLILNEAS VSIQTCFKTN NITRLTSWTV ILGRLACLES EKFSGTLPNS 
       490        500        510        520        530        540 
TKDMDNWYVC HLCDIEKTGN PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL 
       550        560        570        580        590        600 
SGILFSLHRI FSHFQPPKLT DGNGQINKSF KLVQKCFMNS NRYLRLLSTR IIPLFNISDS 
       610        620        630        640        650        660 
HNSEDEHTAT LIKFLQSQKL PVVKENLVIA WTQLTLTTSN DVFDTLLLKL IDIFNSDDYS 
       670        680        690        700        710        720 
LRIMMTLQIK NMAKILKKTP YQLLSPILPV LLRQLGKNLV ERKVGFQNLI ELLGYSSKTI 
       730        740        750        760        770        780 
LDIFQRYIIP YAIIQYKSDV LSEIAKIMCD GDTSLINQMK VNLLKKNSRQ IFAVALVKHG 
       790        800        810        820        830        840 
LFSLDILETL FLNRAPTFDK GYITAYLPDY KTLAEITKLY KNSVTKDASD SENANMILCS 
       850        860        870        880        890        900 
LRFLITNFEK DKRHGSKYKN INNWTDDQEQ AFQKKLQDNI LGIFQVFSSD IHDVEGRTTY 
       910        920        930        940        950        960 
YEKLRVINGI SFLIIYAPKK SIISALAQIS ICLQTGLGLK EVRYEAFRCW HLLVRHLNDE 
       970        980        990       1000       1010       1020 
ELSTVIDSLI AFILQKWSEF NGKLRNIVYS ILDTLIKEKS DLILKLKPYT TLALVGKPEL 
      1030       1040       1050       1060       1070       1080 
GILARDGQFA RMVNKIRSTT DLIPIFANNL KSSNKYVINQ NLDDIEVYLR RKQTERSIDF 
      1090       1100       1110       1120       1130       1140 
TPKKVGQTSD ITLVLGALLD TSHKFRNLDK DLCEKCAKCI SMIGVLDVTK HEFKRTTYSE 
      1150       1160       1170       1180       1190       1200 
NEVYDLNDSV QTIKFLIWVI NDILVPAFWQ SENPSKQLFV ALVIQESLKY CGLSSESWDM 
      1210       1220       1230       1240       1250       1260 
NHKELYPNEA KLWEKFNSVS KTTIYPLLSS LYLAQSWKEY VPLKYPSNNF KEGYKIWVKR 
      1270       1280       1290       1300       1310       1320 
FTLDLLKTGT TENHPLHVFS SLIREDDGSL SNFLLPYISL DIIIKAEKGT PYADILNGII 
      1330       1340       1350       1360       1370       1380 
IEFDSIFTCN LEGMNNLQVD SLRMCYESIF RVFEYCKKWA TEFKQNYSKL HGTFIIKDTK 
      1390       1400       1410       1420       1430       1440 
TTNMLLRIDE FLRTTPSDLL AQRSLETDSF ERSALYLEQC YRQNPHDKNQ NGQLLKNLQI 
      1450       1460       1470       1480       1490       1500 
TYEEIGDIDS LDGVLRTFAT GNLVSKIEEL QYSENWKLAQ DCFNVLGKFS DDPKTTTRML 
      1510       1520       1530       1540       1550       1560 
KSMYDHQLYS QIISNSSFHS SDGKISLSPD VKEWYSIGLE AANLEGNVQT LKNWVEQIES 
      1570       1580       1590       1600       1610       1620 
LRNIDDREVL LQYNIAKALI AISNEDPLRT QKYIHNSFRL IGTNFITSSK ETTLLKKQNL 
      1630       1640       1650       1660       1670       1680 
LMKLHSLYDL SFLSSAKDKF EYKSNTTILD YRMERIGADF VPNHYILSMR KSFDQLKMNE 
      1690       1700       1710       1720       1730       1740 
QADADLGKTF FTLAQLARNN ARLDIASESL MHCLERRLPQ AELEFAEILW KQGENDRALK 
      1750       1760       1770       1780       1790       1800 
IVQEIHEKYQ ENSSVNARDR AAVLLKFTEW LDLSNNSASE QIIKQYQDIF QIDSKWDKPY 
      1810       1820       1830       1840       1850       1860 
YSIGLYYSRL LERKKAEGYI TNGRFEYRAI SYFLLAFEKN TAKVRENLPK VITFWLDIAA 
      1870       1880       1890       1900       1910       1920 
ASISEAPGNR KEMLSKATED ICSHVEEALQ HCPTYIWYFV LTQLLSRLLH SHQSSAQIIM 
      1930       1940       1950       1960       1970       1980 
HILLSLAVEY PSHILWYITA LVNSNSSKRV LRGKHILEKY RQHSQNPHDL VSSALDLTKA 
      1990       2000       2010       2020       2030       2040 
LTRVCLQDVK SITSRSGKSL EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF 
      2050       2060       2070       2080       2090       2100 
RPVVSIIRFG SSYKVFSSLK KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL 
      2110       2120       2130       2140       2150       2160 
LSKDIASRKR SLGINIYSVL SLREDCGILE MVPNVVTLRS ILSTKYESLK IKYSLKSLHD 
      2170       2180       2190       2200       2210       2220 
RWQHTAVDGK LEFYMEQVDK FPPILYQWFL ENFPDPINWF NARNTYARSY AVMAMVGHIL 
      2230       2240       2250       2260       2270       2280 
GLGDRHCENI LLDIQTGKVL HVDFDCLFEK GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT 
      2290       2300       2310       2320       2330       2340 
FKKSSEVTLA LMRKNEVALM NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV 
      2350       2360    
AGQTETLIQE ATSEDNLSKM YIGWLPFW

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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Chains:
 
 
N-termini:

N
 
C-termini:
C
 
Features:
  
 
 
 
Sequence variations:
              
 
unknown-1MESHVK...
1,2368

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,2368,2368,1 CHAIN - Serine/threonine-protein kinase MEC1. (1|2368)
 

Protein C-Termini [export]

...WLPFW2368-unknown
2368,2368

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

2368,2368,2368,2082 DOMAIN - PI3K/PI4K. (2082|2368)
2368,2368,2368,2336 DOMAIN - FATC. (2336|2368)
2368,2368,2368,2140 REGION - Binding to the RPA complex. (2140|2368)
2368,2368,2368,2367 MUTAGEN - FW->AA: In MEC1-87; decreases the level of MEC1 and impairs viability. (2367|2368)
2368,2368,2368,1 CHAIN - Serine/threonine-protein kinase MEC1. (1|2368)
 
Filter by evidence: ?

Directness ?

  • unknown

Physiological relevance ?

  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?