P47879: Insulin-like growth factor-binding protein 4 (Mouse)

Protein names
  • Insulin-like growth factor-binding protein 4 (IBP-4)
  • IBP4
Gene names Igfbp4
Organism Mus musculus
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 11

Sequence

        10         20         30         40         50         60 
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA 
        70         80         90        100        110        120 
LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC TELSEIEAIQ ESLQTSDKDE 
       130        140        150        160        170        180 
SEHPNNSFNP CSAHDHRCLQ KHMAKIRDRS KMKIVGTPRE EPRPVPQGSC QSELHRALER 
       190        200        210        220        230        240 
LAASQSRTHE DLFIIPIPNC DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK 
       250    
GELDCHQLAD SFQE

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
Chains:
 
 
N-termini:
N
N
N
NNNNN
 
C-termini:
C
CCCCC
 
Cleavage sites:
     
 
 
Features:
   
 
Sequence variations:
    
 
(RPSLG(21)|(22)DEAIH)
21,254

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Affected feature boundaries: ?

21,254,21,1 SIGNAL - By similarity. (1|21)
21,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)
 
(LGDEA(24)|(25)IHCPP)
24,254

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none
 
(EKPLR(91)|(92)TLMHG)
91,254

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP2_MOUSE -> IBP4_MOUSE @91 unknown none

Targeted features: ?

91,254,103,23 DOMAIN - IGFBP N-terminal. (23|103)
91,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)
91,254,100,74 DISULFID - By similarity. (74|100)
 
(EHPNN(126)|(127)SFNPC)
126,254

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Targeted features: ?

126,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)

Affected feature boundaries: ?

126,254,125,125 CARBOHYD - N-linked (GlcNAc...) (Potential). (125|125)
 
(PRPVP(166)|(167)QGSCQ)
166,254

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Matrix metalloproteinase-9 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Targeted features: ?

166,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)

Affected feature boundaries: ?

166,254,245,167 DOMAIN - Thyroglobulin type-1. (167|245)
 
acetylation-21GDEAIH...
21,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Overall CM. auf dem Keller U.: A statistics-based platform for quantitative N-terminome... direct likely 0.0 (unknown)
 
unknown-22DEAIHC...
22,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from similarity UniProtKB inferred from uniprot (by similarity) unknown unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC33572 indirect unknown (unknown)

Affected feature boundaries: ?

22,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)
 
unknown-22DEAIHC...
22,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Overall CM. Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... direct likely 0.0 (unknown)
Kleifeldt O. et al.: N-terminome analysis of bronchoalveolar lavage fluids collected from... unknown unknown (unknown)
Overall CM. Prudova A.: Multiplex N-terminome analysis of MMP-2 and MMP-9... direct likely 0.0 (unknown)

Affected feature boundaries: ?

22,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)
 
unknown-25IHCPPC...
25,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33573 indirect unknown (unknown)
 
unknown-80CYPPRG...
80,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Overall CM. Kleifeldt O. et al.: Isotopic labeling of terminal amines in complex samples identifies... direct likely 0.0 (unknown)
 
unknown-92TLMHGQ...
92,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33574 indirect unknown (unknown)
 
unknown-127SFNPCS...
127,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33575 indirect unknown (unknown)
 
unknown-167QGSCQS...
167,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33576 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34626 indirect unknown (unknown)

Affected feature boundaries: ?

167,254,245,167 DOMAIN - Thyroglobulin type-1. (167|245)
 

Protein C-Termini [export]

...RPSLG21-unknown
21,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33572 indirect unknown (unknown)

Affected feature boundaries: ?

21,254,21,1 SIGNAL - By similarity. (1|21)
 
...LGDEA24-unknown
24,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33573 indirect unknown (unknown)
 
...EKPLR91-unknown
91,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33574 indirect unknown (unknown)
 
...EHPNN126-unknown
126,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33575 indirect unknown (unknown)
 
...PRPVP166-unknown
166,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33576 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34626 indirect unknown (unknown)
 
...DSFQE254-unknown
254,254

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

254,254,254,22 CHAIN - Insulin-like growth factor-binding protein 4. (22|254)
 
Filter by evidence: ?

Directness ?

  • unknown
  • direct
  • indirect

Physiological relevance ?

  • none
  • likely
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?