P51512: Matrix metalloproteinase-16 (Human)

Protein names
  • Matrix metalloproteinase-16 (MMP-16)
  • MMP-X2 (MMP-16)
  • Membrane-type matrix metalloproteinase 3 Short=MT-MMP 3 Short=MTMMP3 (MMP-16)
  • Membrane-type-3 matrix metalloproteinase Short=MT3-MMP Short=MT3MMP (MMP-16)
  • MMP16
Gene names MMP16 (MMPX2)
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.016 (MEROPS)
Chromosome 8

Isoforms

  • Isoform Short of Matrix metalloproteinase-16 (P51512-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MILLTFSTGR RLDFVHHSGV FFLQTLLWIL CATVCGTEQY FNVEVWLQKY GYLPPTDPRM 
        70         80         90        100        110        120 
SVLRSAETMQ SALAAMQQFY GINMTGKVDR NTIDWMKKPR CGVPDQTRGS SKFHIRRKRY 
       130        140        150        160        170        180 
ALTGQKWQHK HITYSIKNVT PKVGDPETRK AIRRAFDVWQ NVTPLTFEEV PYSELENGKR 
       190        200        210        220        230        240 
DVDITIIFAS GFHGDSSPFD GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL 
       250        260        270        280        290        300 
FLVAVHELGH ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDKIPPPT 
       310        320        330        340        350        360 
RPLPTVPPHR SIPPADPRKN DRPKPPRPPT GRPSYPGAKP NICDGNFNTL AILRREMFVF 
       370        380        390        400        410        420 
KDQWFWRVRN NRVMDGYPMQ ITYFWRGLPP SIDAVYENSD GNFVFFKGNK YWVFKDTTLQ 
       430        440        450        460        470        480 
PGYPHDLITL GSGIPPHGID SAIWWEDVGK TYFFKGDRYW RYSEEMKTMD PGYPKPITVW 
       490        500        510        520        530        540 
KGIPESPQGA FVHKENGFTY FYKGKEYWKF NNQILKVEPG YPRSILKDFM GCDGPTDRVK 
       550        560        570        580        590        600 
EGHSPPDDVD IVIKLDNTAS TVKAIAIVIP CILALCLLVL VYTVFQFKRK GTPRHILYCK 
   
RSMQEWV

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
Chains:
 
 
N-termini:

NNN
N
 
C-termini:
CC
 
Cleavage sites:
 
 
Features:
  
 
 
Binding & active sites:
                 
 
Sequence variations:
  
 
 
(KFHIR(116)|(117)RKRYA)
116,607

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Kang T et al.:Activation of membrane-type mat... (S08.071) unknown yes
 
unknown-1MILLTF...
1,607

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt81286 indirect unknown (unknown)

Affected feature boundaries: ?

1,607,31,1 SIGNAL - Potential. (1|31)
 
unknown-32ATVCGT...
32,607

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt114935 indirect unknown (unknown)

Affected feature boundaries: ?

32,607,119,32 PROPEP - By similarity. (32|119)
 
unknown-117RKRYAL...
117,607

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9770 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt143313 indirect unknown (unknown)
 
unknown-120YALTGQ...
120,607

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt115904 indirect unknown (unknown)

Affected feature boundaries: ?

120,607,564,120 TOPO_DOM - Extracellular (Potential). (120|564)
120,607,607,120 CHAIN - Matrix metalloproteinase-16. (120|607)
 

Protein C-Termini [export]

...KFHIR116-unknown
116,607

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9770 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt126543 indirect unknown (unknown)
 
...MQEWV607-unknown
607,607

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

607,607,607,458 VAR_SEQ - Missing (in isoform Short). (458|607)
607,607,607,586 TOPO_DOM - Cytoplasmic (Potential). (586|607)
607,607,607,120 CHAIN - Matrix metalloproteinase-16. (120|607)
 
118 (NSFG.|.LRFG)
118,138

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sato H Takino T et al.:Cleavage of metastasis suppress... (M10.014) unknown yes
 
332 ()
332,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
448 ()
448,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
491 ()
491,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
554 ()
554,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
388 ()
388,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
504 ()
504,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
547 ()
547,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
610 ()
610,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
388 ()
388,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
504 ()
504,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
547 ()
547,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
592 ()
592,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
407 ()
407,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
523 ()
523,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
566 ()
566,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
629 ()
629,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
407 ()
407,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
523 ()
523,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
566 ()
566,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
611 ()
611,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
439 ()
439,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
555 ()
555,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
598 ()
598,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
661 ()
661,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
444 ()
444,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
560 ()
560,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
603 ()
603,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
666 ()
666,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
444 ()
444,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
560 ()
560,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
603 ()
603,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
648 ()
648,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
463 (RVEA.|.MLND)
463,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sato H Ahmad M et al.:Cleavage of amyloid-beta precur... (M10.016) unknown yes
 
579 (VLAN.|.MISE)
579,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sato H Ahmad M et al.:Cleavage of amyloid-beta precur... (M10.016) unknown yes
 
622 (QPWH.|.SFGA)
622,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sato H Ahmad M et al.:Cleavage of amyloid-beta precur... (M10.016) unknown yes
 
685 (EVHH.|.QKLV)
685,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sato H Ahmad M et al.:Cleavage of amyloid-beta precur... (M10.016) unknown yes
 
463 ()
463,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21630 indirect unknown
 
579 ()
579,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21640 indirect unknown
 
622 ()
622,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21650 indirect unknown
 
667 ()
667,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21660 indirect unknown
 
948 (GPLG.|.IAGI)
948,1466

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Shimada T et al.:Characterization of a truncated... (M10.016) unknown yes
 
951 (GIAG.|.ITGA)
951,1466

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Okada Y Shimada T et al.:Characterization of a truncated... (M10.016) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?