P51798: H(+)/Cl(-) exchange transporter 7 (Human)

Protein names
  • H(+)/Cl(-) exchange transporter 7
  • Chloride channel 7 alpha subunit
  • Chloride channel protein 7 Short=ClC-7
  • CLCN7
Gene names CLCN7
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 16

Isoforms

  • Isoform 2 of H(+)/Cl(-) exchange transporter 7 (P51798-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MANVSKKVSW SGRDRDDEEA APLLRRTARP GGGTPLLNGA GPGAARQSPR SALFRVGHMS 
        70         80         90        100        110        120 
SVELDDELLD PDMDPPHPFP KEIPHNEKLL SLKYESLDYD NSENQLFLEE ERRINHTAFR 
       130        140        150        160        170        180 
TVEIKRWVIC ALIGILTGLV ACFIDIVVEN LAGLKYRVIK GNIDKFTEKG GLSFSLLLWA 
       190        200        210        220        230        240 
TLNAAFVLVG SVIVAFIEPV AAGSGIPQIK CFLNGVKIPH VVRLKTLVIK VSGVILSVVG 
       250        260        270        280        290        300 
GLAVGKEGPM IHSGSVIAAG ISQGRSTSLK RDFKIFEYFR RDTEKRDFVS AGAAAGVSAA 
       310        320        330        340        350        360 
FGAPVGGVLF SLEEGASFWN QFLTWRIFFA SMISTFTLNF VLSIYHGNMW DLSSPGLINF 
       370        380        390        400        410        420 
GRFDSEKMAY TIHEIPVFIA MGVVGGVLGA VFNALNYWLT MFRIRYIHRP CLQVIEAVLV 
       430        440        450        460        470        480 
AAVTATVAFV LIYSSRDCQP LQGGSMSYPL QLFCADGEYN SMAAAFFNTP EKSVVSLFHD 
       490        500        510        520        530        540 
PPGSYNPLTL GLFTLVYFFL ACWTYGLTVS AGVFIPSLLI GAAWGRLFGI SLSYLTGAAI 
       550        560        570        580        590        600 
WADPGKYALM GAAAQLGGIV RMTLSLTVIM MEATSNVTYG FPIMLVLMTA KIVGDVFIEG 
       610        620        630        640        650        660 
LYDMHIQLQS VPFLHWEAPV TSHSLTAREV MSTPVTCLRR REKVGVIVDV LSDTASNHNG 
       670        680        690        700        710        720 
FPVVEHADDT QPARLQGLIL RSQLIVLLKH KVFVERSNLG LVQRRLRLKD FRDAYPRFPP 
       730        740        750        760        770        780 
IQSIHVSQDE RECTMDLSEF MNPSPYTVPQ EASLPRVFKL FRALGLRHLV VVDNRNQVVG 
       790        800    
LVTRKDLARY RLGKRGLEEL SLAQT

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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Chains:
 
 
N-termini:

NN
 
C-termini:
CC
C
 
Cleavage sites:
 
 
Features:
  
     
 
Binding & active sites:
     
 
Modifications:
 
 
(HTAFR(120)|(121)TVEIK)
120,805

Granzyme B (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Gevaert K Van Damme P et al.:Complementary positional proteo... (M14.017) unknown none

Targeted features: ?

120,805,126,1 TOPO_DOM - Cytoplasmic (By similarity). (1|126)
120,805,805,1 CHAIN - H(+)/Cl(-) exchange transporter 7. (1|805)
 
unknown-1MANVSK...
1,805

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt70935 indirect unknown (unknown)

Affected feature boundaries: ?

1,805,126,1 TOPO_DOM - Cytoplasmic (By similarity). (1|126)
1,805,805,1 CHAIN - H(+)/Cl(-) exchange transporter 7. (1|805)
 
unknown-121TVEIKR...
121,805

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC11644 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt142249 indirect unknown (unknown)
 

Protein C-Termini [export]

...HTAFR120-unknown
120,805

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC11644 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt125438 indirect unknown (unknown)
 
...SLAQT805-unknown
805,805

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Gevaert K. Van Damme P et al.: Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

805,805,805,598 TOPO_DOM - Cytoplasmic (By similarity). (598|805)
805,805,805,1 CHAIN - H(+)/Cl(-) exchange transporter 7. (1|805)
 
...SLAQT805-unknown
805,805

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt66553 indirect unknown (unknown)
Gevaert K. Van Damme P et al.: Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

805,805,805,598 TOPO_DOM - Cytoplasmic (By similarity). (598|805)
805,805,805,1 CHAIN - H(+)/Cl(-) exchange transporter 7. (1|805)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect
  • direct

Physiological relevance ?

  • none
  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?