P61981: 14-3-3 protein gamma (Human)

Protein names
  • 14-3-3 protein gamma
  • Protein kinase C inhibitor protein 1 Short=KCIP-1
  • 1433G
Gene names YWHAG
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 7

Sequence

        10         20         30         40         50         60 
MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW 
        70         80         90        100        110        120 
RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK 
       130        140        150        160        170        180 
VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS 
       190        200        210        220        230        240 
VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD 
   
DGGEGNN

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
Chains:
 
 
 
N-termini:

N
N
N
NNNN
NN
 
C-termini:
CCC
C
 
Cleavage sites:
  
 
Features:
   
 
Sequence variations:
            
 
Modifications:
  
  
 
(EKAYS(155)|(156)EAHEI)
155,247

Cathepsin L1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none

Targeted features: ?

155,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
155,247,247,2 CHAIN - 14-3-3 protein gamma, N-terminally processed. (2|247)
155,247,164,140 HELIX - (140|164)
 
(YYEIQ(187)|(188)NAPEQ)
187,247

Cathepsin S (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none

Targeted features: ?

187,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
187,247,247,2 CHAIN - 14-3-3 protein gamma, N-terminally processed. (2|247)
 
acetylation-1MVDREQ...
1,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,247,1,1 INIT_MET - Removed; alternate. (1|1)
1,247,1,1 MOD_RES - N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial. (1|1)
1,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
 
unknown-1MVDREQ...
1,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... unknown unknown (unknown)
Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... unknown unknown (unknown)

Affected feature boundaries: ?

1,247,1,1 INIT_MET - Removed; alternate. (1|1)
1,247,1,1 MOD_RES - N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial. (1|1)
1,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
 
unknown-1MVDREQ...
1,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_Etoposide direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)

Affected feature boundaries: ?

1,247,1,1 INIT_MET - Removed; alternate. (1|1)
1,247,1,1 MOD_RES - N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial. (1|1)
1,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
 
acetylation-2VDREQL...
2,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
CNRS/ISV Large_scale_NTA_Human direct yes 0.0 (MASCOT score)

Affected feature boundaries: ?

2,247,2,2 MOD_RES - N-acetylvaline; in 14-3-3 protein gamma, N-terminally processed; partial. (2|2)
2,247,2,2 MOD_RES - N-acetylvaline; partial. (2|2)
2,247,247,2 CHAIN - 14-3-3 protein gamma, N-terminally processed. (2|247)
 
unknown-29NVTELN...
29,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1s_bort direct yes 0.02 (ProteinProspector)
Wells MM1SDBJurkat_Untreated direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1SDBJurkat_Mix direct yes 0.02 (ProteinProspector)
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-62VISSIE...
62,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells Jurkat_untreated direct yes 0.02 (ProteinProspector)
 
unknown-153AYSEAH...
153,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-156EAHEIS...
156,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC6106 indirect unknown (unknown)
 
unknown-188NAPEQA...
188,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC7631 indirect unknown (unknown)
 

Protein C-Termini [export]

...EKAYS155-unknown
155,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC6106 indirect unknown (unknown)
 
...YYEIQ187-unknown
187,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC7631 indirect unknown (unknown)
 
...GEGNN247-unknown
247,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

247,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
247,247,247,2 CHAIN - 14-3-3 protein gamma, N-terminally processed. (2|247)
 
...GEGNN247-unknown
247,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

247,247,247,1 CHAIN - 14-3-3 protein gamma. (1|247)
247,247,247,2 CHAIN - 14-3-3 protein gamma, N-terminally processed. (2|247)
 
Filter by evidence: ?

Directness ?

  • unknown
  • direct
  • indirect

Physiological relevance ?

  • none
  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector
  • MASCOT score

Experimental system ?

Certainty of Protease assignment ?

  • unknown
  • III proteolytic system present but impaired

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?