P78325: Disintegrin and metalloproteinase domain-containing protein 8 (Human)

Protein names
  • Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8)
  • Cell surface antigen MS2 (ADAM 8)
  • ADAM8
Gene names ADAM8 (MS2)
Organism Homo sapiens
Protease Family M12 (MEROPS)
Protease ID M12.208 (MEROPS)
Chromosome 10

Isoforms

  • Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 8 (P78325-2): sequence view | extended view
  • Isoform 3 of Disintegrin and metalloproteinase domain-containing protein 8 (P78325-3): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPWRLPGP RVRRALPSHL GLHPERVSYV 
        70         80         90        100        110        120 
LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS 
       130        140        150        160        170        180 
LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP 
       190        200        210        220        230        240 
RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL 
       250        260        270        280        290        300 
NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT 
       310        320        330        340        350        360 
VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG 
       370        380        390        400        410        420 
RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE 
       430        440        450        460        470        480 
QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD 
       490        500        510        520        530        540 
GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK 
       550        560        570        580        590        600 
ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG 
       610        620        630        640        650        660 
RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVFVVV 
       670        680        690        700        710        720 
VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS 
       730        740        750        760        770        780 
RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA 
       790        800        810        820    
PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
700
800
Chains:
 
 
N-termini:

NNN
NN
 
C-termini:
CC
C
 
Cleavage sites:
 
 
 
 
 
 
 
Features:
    
 
Binding & active sites:
    
 
Sequence variations:
 
  
        
  
 
 
 
(SRETR(200)|(201)YVELY)
200,824

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Targeted features: ?

200,824,655,17 TOPO_DOM - Extracellular (Potential). (17|655)
200,824,824,17 CHAIN - Disintegrin and metalloproteinase domain- containing protein 8. (17|824)

Affected feature boundaries: ?

200,824,208,200 STRAND - (200|208)
200,824,400,200 DOMAIN - Peptidase M12B. (200|400)
 
unknown-1MRGLGL...
1,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt66341 indirect unknown (unknown)

Affected feature boundaries: ?

1,824,16,1 SIGNAL - Potential. (1|16)
 
unknown-17IAPSRP...
17,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt111919 indirect unknown (unknown)

Affected feature boundaries: ?

17,824,655,17 TOPO_DOM - Extracellular (Potential). (17|655)
17,824,824,17 CHAIN - Disintegrin and metalloproteinase domain- containing protein 8. (17|824)
 
unknown-92GSEVTE...
92,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_MM1s_bort direct yes 0.02 (ProteinProspector)
 
unknown-92GSEVTE...
92,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt176302 indirect unknown (unknown)
 
unknown-201YVELYV...
201,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26631 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26902 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9781 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27200 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27050 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27347 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt145199 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt146585 indirect unknown (unknown)
 

Protein C-Termini [export]

...SRETR200-unknown
200,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26631 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26902 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9781 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27200 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27050 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27347 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt128487 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt129892 indirect unknown (unknown)
 
...APTAP824-unknown
824,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

824,824,824,743 VAR_SEQ - Missing (in isoform 3). (743|824)
824,824,824,677 TOPO_DOM - Cytoplasmic (Potential). (677|824)
824,824,824,17 CHAIN - Disintegrin and metalloproteinase domain- containing protein 8. (17|824)
 
...APTAP824-unknown
824,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt61958 indirect unknown (unknown)
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

824,824,824,743 VAR_SEQ - Missing (in isoform 3). (743|824)
824,824,824,677 TOPO_DOM - Cytoplasmic (Potential). (677|824)
824,824,824,17 CHAIN - Disintegrin and metalloproteinase domain- containing protein 8. (17|824)
 
74 (SPLA.|.QAVR)
74,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
76 (LAQA.|.VRSS)
76,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
80 (DQMA.|.QKSQ)
80,321

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Werb Z Lemieux GA et al.:The low affinity IgE receptor (... (M12.210) unknown unknown
 
98 (LRAE.|.QQRL)
98,321

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Werb Z Lemieux GA et al.:The low affinity IgE receptor (... (M12.210) unknown unknown
 
99 (RAEQ.|.QRLK)
99,321

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Werb Z Lemieux GA et al.:The low affinity IgE receptor (... (M12.210) unknown unknown
 
292 (VRAA.|.VYQP)
292,2386

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Tortorella MD Zack MD et al.:ADAM-8 isolated from human oste... (M12.208) unknown yes
 
292 ()
292,2330

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,657

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2477

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2265

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2267

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2008

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2386

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2176

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2240

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2296

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2446

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2184

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2211

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2031

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,2355

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
292 ()
292,642

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC181 indirect unknown
 
554 ()
554,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
592 ()
592,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
610 ()
610,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
611 ()
611,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
629 ()
629,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
648 ()
648,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
661 ()
661,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
666 ()
666,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
667 ()
667,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC198 indirect unknown
 
685 (EVHH.|.QKLV)
685,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect
  • direct

Physiological relevance ?

  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?