P78536: Disintegrin and metalloproteinase domain-containing protein 17 (Human)

Protein names
  • Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)
  • Snake venom-like protease (ADAM 17)
  • TNF-alpha convertase (ADAM 17)
  • TNF-alpha-converting enzyme (ADAM 17)
  • ADA17
Gene names ADAM17 (CSVP)
Organism Homo sapiens
Protease Family M12 (MEROPS)
Protease ID M12.217 (MEROPS)
Chromosome 2

Isoforms

  • Isoform B of Disintegrin and metalloproteinase domain-containing protein 17 (P78536-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 
        70         80         90        100        110        120 
QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD GKNESEYTVK WQDFFTGHVV 
       130        140        150        160        170        180 
GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 
       190        200        210        220        230        240 
PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG 
       250        260        270        280        290        300 
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 
       310        320        330        340        350        360 
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 
       370        380        390        400        410        420 
HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 
       430        440        450        460        470        480 
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 
       490        500        510        520        530        540 
SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 
       550        560        570        580        590        600 
TCKGVSYCTG NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 
       610        620        630        640        650        660 
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 
       670        680        690        700        710        720 
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHP SNVEMLSSMD 
       730        740        750        760        770        780 
SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA APKLDHQRMD TIQEDPSTDS HMDEDGFEKD 
       790        800        810        820    
PFPNSSTAAK SFEDLTDHPV TRSEKAASFK LQRQNRVDSK ETEC

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
700
800
Chains:
 
 
N-termini:

NNN
 
C-termini:
CCC
 
Cleavage sites:
 
 
 
 
 
 
Features:
  
      
 
Binding & active sites:
     
 
Sequence variations:
     
  
 
Modifications:
   
 
(HRVKR(214)|(215)RADPD)
214,824

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Affected feature boundaries: ?

214,824,671,215 TOPO_DOM - Extracellular (Potential). (215|671)
214,824,824,215 CHAIN - Disintegrin and metalloproteinase domain- containing protein 17. (215|824)
214,824,214,18 PROPEP - (18|214)
 
unknown-1MRQSLL...
1,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt66268 indirect unknown (unknown)

Affected feature boundaries: ?

1,824,17,1 SIGNAL - Potential. (1|17)
 
unknown-18PRPPDD...
18,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt112041 indirect unknown (unknown)

Affected feature boundaries: ?

18,824,214,18 PROPEP - (18|214)
 
unknown-215RADPDP...
215,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26634 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26905 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27203 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27053 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27350 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt116043 indirect unknown (unknown)

Affected feature boundaries: ?

215,824,671,215 TOPO_DOM - Extracellular (Potential). (215|671)
215,824,824,215 CHAIN - Disintegrin and metalloproteinase domain- containing protein 17. (215|824)
 

Protein C-Termini [export]

...HRVKR214-unknown
214,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26634 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26905 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27203 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27053 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27350 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt130490 indirect unknown (unknown)

Affected feature boundaries: ?

214,824,214,18 PROPEP - (18|214)
 
...LVHCV694-unknown
694,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TCt61886 indirect unknown (unknown)
 
...KETEC824-unknown
824,824

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

824,824,824,695 VAR_SEQ - Missing (in isoform B). (695|824)
824,824,824,693 TOPO_DOM - Cytoplasmic (Potential). (693|824)
824,824,824,215 CHAIN - Disintegrin and metalloproteinase domain- containing protein 17. (215|824)
 
31 (RLRR.|.GLAA)
31,208

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown yes
 
62 (RKVR.|.DLQE)
62,208

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown yes
 
72 (LDLL.|.RVTL)
72,208

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown yes
 
73 (DLLR.|.VTLS)
73,208

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown yes
 
149 (LSLP.|.VENR)
149,208

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown yes
 
39 (VAAA.|.VVSH)
39,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Moss ML Hinkle CL et al.:Multiple metalloproteinases pro... (M12.210) unknown yes
 
89 (DLLA.|.VVAA)
89,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Sunnarborg SW et al.:Tumor necrosis factor-alpha con... (M12.217) unknown yes
 
39 ()
39,163

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC110 indirect unknown
 
89 ()
89,163

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC112 indirect unknown
 
62 (RVAQ.|.VSIT)
62,169

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Sunnarborg SW et al.:Tumor necrosis factor-alpha con... (M12.217) unknown none
 
108 (HFFL.|.TVHQ)
108,169

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Sunnarborg SW et al.:Tumor necrosis factor-alpha con... (M12.217) unknown none
 
76 (LAQA.|.VRSS)
76,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ADA17_HUMAN -> TNFA_HUMAN @76 unknown yes
 
88 ()
88,162

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC112 indirect unknown
 
88 ()
88,161

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC112 indirect unknown
 
88 ()
88,159

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC112 indirect unknown
 
104 ()
104,246

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC118 indirect unknown
 
106 (RVEQ.|.VVKP)
106,252

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown yes
 
187 (KSMK.|.THSM)
187,252

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Hinkle CL et al.:Selective roles for tumor necro... (M12.217) unknown none
 
111 (NMKH.|.MAGA)
111,253

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Checler F Alfa Cisse M et al.:M1 and M3 muscarinic receptors ... (M12.217) unknown none
 
111 (DLFY.|.LRGD)
111,178

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Lee DC Sunnarborg SW et al.:Tumor necrosis factor-alpha con... (M12.217) unknown none
 
321 (KLDK.|.SFSM)
321,372

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Black RA Peschon JJ et al.:An essential role for ectodomai... (M12.217) unknown none
 
334 ()
334,385

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC134 indirect unknown
 
357 (LPVQ.|.DSSS)
357,468

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Mullberg J Althoff K et al.:Shedding of interleukin-6 recep... (M12.217) unknown yes
 
556 ()
556,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
594 ()
594,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
612 ()
612,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
613 ()
613,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
617 ()
617,691

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC131 indirect unknown
 
631 ()
631,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
641 (WTGH.|.STLP)
641,1308

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Carpenter G Cheng QC et al.:Ectodomain cleavage of ErbB-4: ... (M12.217) unknown yes
 
641 ()
641,1292

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC140 indirect unknown
 
650 ()
650,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
658 ()
658,732

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC131 indirect unknown
 
663 ()
663,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
668 ()
668,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
669 ()
669,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC120 indirect unknown
 
687 (HHQK.|.LVFF)
687,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Milla ME Mohan MJ et al.:The tumor necrosis factor-alpha... (M12.217) unknown yes
 
803 (HVNH.|.LIVQ)
803,955

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
834 (SIAT.|.VVII)
834,955

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
837 (TVVI.|.IISV)
837,955

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
812 (HPSH.|.VLSS)
812,956

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
849 (SAAT.|.LIIV)
849,956

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
852 (TLII.|.VVCV)
852,956

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Suzuki T Hata S et al.:Alcadein cleavages by amyloid b... (M12.210) unknown yes
 
824 ()
824,968

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC147 indirect unknown
 
861 ()
861,968

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC149 indirect unknown
 
864 ()
864,968

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC151 indirect unknown
 
1232 (NSAR.|.SEGP)
1232,1306

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ADA17_HUMAN -> ACE_HUMAN @1232 unknown yes
 
1753 (VGCG.|.VLLS)
1753,2555

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops ADA17_HUMAN -> NOTC1_HUMAN @1753 unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • unknown
  • yes
  • none

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?