Q13443: Disintegrin and metalloproteinase domain-containing protein 9 (Human)

Protein names
  • Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9)
  • Cellular disintegrin-related protein (ADAM 9)
  • Meltrin-gamma (ADAM 9)
  • Metalloprotease/disintegrin/cysteine-rich protein 9 (ADAM 9)
  • Myeloma cell metalloproteinase (ADAM 9)
  • ADAM9
Gene names ADAM9 (KIAA0021, MCMP, MDC9, MLTNG)
Organism Homo sapiens
Protease Family M12 (MEROPS)
Protease ID M12.209 (MEROPS)
Chromosome 8

Isoforms

  • Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 9 (Q13443-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR 
        70         80         90        100        110        120 
PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE GTLITDHPNI QNHCHYRGYV 
       130        140        150        160        170        180 
EGVHNSSIAL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK 
       190        200        210        220        230        240 
DIEKETAKDE EEEPPSMTQL LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI 
       250        260        270        280        290        300 
LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS 
       310        320        330        340        350        360 
AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG 
       370        380        390        400        410        420 
RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK 
       430        440        450        460        470        480 
LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC 
       490        500        510        520        530        540 
DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF 
       550        560        570        580        590        600 
IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC 
       610        620        630        640        650        660 
WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK 
       670        680        690        700        710        720 
NCHCENGWAP PNCETKGYGG SVDSGPTYNE MNTALRDGLL VFFFLIVPLI VCAIFIFIKR 
       730        740        750        760        770        780 
DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFAVPTYAA 
       790        800        810    
KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
700
800
Chains:
 
 
N-termini:

NNN
NNN
 
C-termini:
C
CCCC
 
Cleavage sites:
 
  
   
 
 
Features:
    
 
Binding & active sites:
    
 
Sequence variations:
 
      
  
 
(SYVIQ(71)|(72)AEGKE)
71,819

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

71,819,697,29 TOPO_DOM - Extracellular (Potential). (29|697)
71,819,118,1 CONFLICT - Missing (in Ref. 2; no nucleotide entry). (1|118)
71,819,819,29 CHAIN - Disintegrin and metalloproteinase domain- containing protein 9. (29|819)
 
(YVIQA(72)|(73)EGKEH)
72,819

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

72,819,697,29 TOPO_DOM - Extracellular (Potential). (29|697)
72,819,118,1 CONFLICT - Missing (in Ref. 2; no nucleotide entry). (1|118)
72,819,819,29 CHAIN - Disintegrin and metalloproteinase domain- containing protein 9. (29|819)
 
(DFVVY(95)|(96)TYNKE)
95,819

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

95,819,697,29 TOPO_DOM - Extracellular (Potential). (29|697)
95,819,118,1 CONFLICT - Missing (in Ref. 2; no nucleotide entry). (1|118)
95,819,819,29 CHAIN - Disintegrin and metalloproteinase domain- containing protein 9. (29|819)
 
(TLITD(106)|(107)HPNIQ)
106,819

Meprin A subunit alpha (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Meprin A subunit beta (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002) unknown none

Targeted features: ?

106,819,697,29 TOPO_DOM - Extracellular (Potential). (29|697)
106,819,118,1 CONFLICT - Missing (in Ref. 2; no nucleotide entry). (1|118)
106,819,819,29 CHAIN - Disintegrin and metalloproteinase domain- containing protein 9. (29|819)
 
unknown-1MGSGAR...
1,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt66342 indirect unknown (unknown)

Affected feature boundaries: ?

1,819,118,1 CONFLICT - Missing (in Ref. 2; no nucleotide entry). (1|118)
1,819,28,1 SIGNAL - Potential. (1|28)
 
unknown-29AARPGF...
29,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt114614 indirect unknown (unknown)

Affected feature boundaries: ?

29,819,697,29 TOPO_DOM - Extracellular (Potential). (29|697)
29,819,819,29 CHAIN - Disintegrin and metalloproteinase domain- containing protein 9. (29|819)
 
unknown-72AEGKEH...
72,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17906 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC19444 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt140804 indirect unknown (unknown)
 
unknown-73EGKEHI...
73,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17908 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC19446 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt140860 indirect unknown (unknown)
 
unknown-96TYNKEG...
96,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19448 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt142220 indirect unknown (unknown)
 
unknown-107HPNIQN...
107,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17910 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC19450 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt142786 indirect unknown (unknown)
 

Protein C-Termini [export]

...SYVIQ71-unknown
71,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17906 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC19444 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt123942 indirect unknown (unknown)
 
...YVIQA72-unknown
72,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17908 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC19446 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt124000 indirect unknown (unknown)
 
...DFVVY95-unknown
95,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC19448 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt125408 indirect unknown (unknown)
 
...TLITD106-unknown
106,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC17910 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC19450 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt125990 indirect unknown (unknown)
 
...YSSLT819-unknown
819,819

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

819,819,819,656 VAR_SEQ - Missing (in isoform 2). (656|819)
819,819,819,719 TOPO_DOM - Cytoplasmic (Potential). (719|819)
819,819,819,736 CONFLICT - Missing (in Ref. 2; no nucleotide entry). (736|819)
819,819,819,29 CHAIN - Disintegrin and metalloproteinase domain- containing protein 9. (29|819)
 
74 (SPLA.|.QAVR)
74,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
79 (AVRS.|.SSRT)
79,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
554 ()
554,639

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
592 ()
592,677

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
610 ()
610,695

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
611 ()
611,696

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
629 ()
629,714

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
648 ()
648,733

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
661 ()
661,746

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
666 ()
666,751

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
667 ()
667,752

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC213 indirect unknown
 
685 (EVHH.|.QKLV)
685,770

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Murphy G Amour A et al.:The enzymatic activity of ADAM8... (M12.210) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • none
  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?