Q14703: Membrane-bound transcription factor site-1 protease (Human)

Protein names
  • Membrane-bound transcription factor site-1 protease
  • Endopeptidase S1P
  • Subtilisin/kexin-isozyme 1 Short=SKI-1
  • MBTP1
Gene names MBTPS1 (KIAA0091, SKI1)
Organism Homo sapiens
Protease Family S08 (MEROPS)
Protease ID S08.063 (MEROPS)
Chromosome 16

Sequence

        10         20         30         40         50         60 
MKLVNIWLLL LVVLLCGKKH LGDRLEKKSF EKAPCPGCSH LTLKVEFSST VVEYEYIVAF 
        70         80         90        100        110        120 
NGYFTAKARN SFISSALKSS EVDNWRIIPR NNPSSDYPSD FEVIQIKEKQ KAGLLTLEDH 
       130        140        150        160        170        180 
PNIKRVTPQR KVFRSLKYAE SDPTVPCNET RWSQKWQSSR PLRRASLSLG SGFWHATGRH 
       190        200        210        220        230        240 
SSRRLLRAIP RQVAQTLQAD VLWQMGYTGA NVRVAVFDTG LSEKHPHFKN VKERTNWTNE 
       250        260        270        280        290        300 
RTLDDGLGHG TFVAGVIASM RECQGFAPDA ELHIFRVFTN NQVSYTSWFL DAFNYAILKK 
       310        320        330        340        350        360 
IDVLNLSIGG PDFMDHPFVD KVWELTANNV IMVSAIGNDG PLYGTLNNPA DQMDVIGVGG 
       370        380        390        400        410        420 
IDFEDNIARF SSRGMTTWEL PGGYGRMKPD IVTYGAGVRG SGVKGGCRAL SGTSVASPVV 
       430        440        450        460        470        480 
AGAVTLLVST VQKRELVNPA SMKQALIASA RRLPGVNMFE QGHGKLDLLR AYQILNSYKP 
       490        500        510        520        530        540 
QASLSPSYID LTECPYMWPY CSQPIYYGGM PTVVNVTILN GMGVTGRIVD KPDWQPYLPQ 
       550        560        570        580        590        600 
NGDNIEVAFS YSSVLWPWSG YLAISISVTK KAASWEGIAQ GHVMITVASP AETESKNGAE 
       610        620        630        640        650        660 
QTSTVKLPIK VKIIPTPPRS KRVLWDQYHN LRYPPGYFPR DNLRMKNDPL DWNGDHIHTN 
       670        680        690        700        710        720 
FRDMYQHLRS MGYFVEVLGA PFTCFDASQY GTLLMVDSEE EYFPEEIAKL RRDVDNGLSL 
       730        740        750        760        770        780 
VIFSDWYNTS VMRKVKFYDE NTRQWWMPDT GGANIPALNE LLSVWNMGFS DGLYEGEFTL 
       790        800        810        820        830        840 
ANHDMYYASG CSIAKFPEDG VVITQTFKDQ GLEVLKQETA VVENVPILGL YQIPAEGGGR 
       850        860        870        880        890        900 
IVLYGDSNCL DDSHRQKDCF WLLDALLQYT SYGVTPPSLS HSGNRQRPPS GAGSVTPERM 
       910        920        930        940        950        960 
EGNHLHRYSK VLEAHLGDPK PRPLPACPRL SWAKPQPLNE TAPSNLWKHQ KLLSIDLDKV 
       970        980        990       1000       1010       1020 
VLPNFRSNRP QVRPLSPGES GAWDIPGGIM PGRYNQEVGQ TIPVFAFLGA MVVLAFFVVQ 
      1030       1040       1050    
INKAKSRPKR RKPRVKRPQL MQQVHPPKTP SV

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
700
800
900
1000
Chains:
 
 
N-termini:
N
NNN
 
C-termini:
C
CCCC
 
Cleavage sites:
   
 
Features:
  
  
 
Binding & active sites:
   
 
Sequence variations:
   
 
Topology:
   
 
(QRKVF(133)|(134)RSLKY)
133,1052

Membrane-bound transcription factor site-1 protease (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MBTP1_HUMAN -> MBTP1_HUMAN @133 unknown yes

Targeted features: ?

133,1052,186,18 PROPEP - (18|186)
 
(FRSLK(137)|(138)YAESD)
137,1052

Membrane-bound transcription factor site-1 protease (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Toure BB et al.:Biosynthesis and enzymatic char... (S08.063) unknown yes

Targeted features: ?

137,1052,186,18 PROPEP - (18|186)
 
(SRRLL(186)|(187)RAIPR)
186,1052

Membrane-bound transcription factor site-1 protease (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Toure BB et al.:Biosynthesis and enzymatic char... (S08.063) unknown yes

Affected feature boundaries: ?

186,1052,187,186 SITE - Cleavage; by autolysis. (186|187)
186,1052,998,187 TOPO_DOM - Lumenal (Potential). (187|998)
186,1052,1052,187 CHAIN - Membrane-bound transcription factor site- 1 protease. (187|1052)
186,1052,186,18 PROPEP - (18|186)
 
unknown-134RSLKYA...
134,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16833 indirect unknown (unknown)
 
unknown-138YAESDP...
138,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16834 indirect unknown (unknown)
 
unknown-187RAIPRQ...
187,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC16835 indirect unknown (unknown)

Affected feature boundaries: ?

187,1052,998,187 TOPO_DOM - Lumenal (Potential). (187|998)
187,1052,1052,187 CHAIN - Membrane-bound transcription factor site- 1 protease. (187|1052)
 
unknown-260MRECQG...
260,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000457954 unknown unknown (unknown)
 

Protein C-Termini [export]

...QRKVF133-unknown
133,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16833 indirect unknown (unknown)
 
...FRSLK137-unknown
137,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16834 indirect unknown (unknown)
 
...SRRLL186-unknown
186,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC16835 indirect unknown (unknown)

Affected feature boundaries: ?

186,1052,186,18 PROPEP - (18|186)
 
...SGVKG405-unknown
405,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000457954 unknown unknown (unknown)
 
...KTPSV1052-unknown
1052,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1052,1052,1052,1022 TOPO_DOM - Cytoplasmic (Potential). (1022|1052)
1052,1052,1052,187 CHAIN - Membrane-bound transcription factor site- 1 protease. (187|1052)
 
57 (RGLT.|.SLAD)
57,247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MBTP1_HUMAN -> BDNF_HUMAN @57 unknown yes
 
65 ()
65,255

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16822 indirect unknown
 
72 ()
72,262

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16822 indirect unknown
 
86 ()
86,276

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16822 indirect unknown
 
133 (RKVF.|.RSLK)
133,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MBTP1_HUMAN -> MBTP1_HUMAN @133 unknown yes
 
137 (RSLK.|.YAES)
137,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Toure BB et al.:Biosynthesis and enzymatic char... (S08.063) unknown yes
 
186 (RRLL.|.RAIP)
186,1052

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Toure BB et al.:Biosynthesis and enzymatic char... (S08.063) unknown yes
 
139 ()
139,329

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16822 indirect unknown
 
250 ()
250,354

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16818 indirect unknown
 
267 ()
267,371

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16818 indirect unknown
 
291 (RQLR.|.ALPS)
291,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes
 
318 ()
318,375

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16840 indirect unknown
 
338 (RNIL.|.THKD)
338,395

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes
 
338 ()
338,431

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16842 indirect unknown
 
362 ()
362,459

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16836 indirect unknown
 
363 ()
363,460

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16836 indirect unknown
 
364 (RTLH.|.NDAA)
364,461

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes
 
419 (RHLL.|.GFSA)
419,670

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Prywes R Chen X et al.:The luminal domain of ATF6 sens... (S08.063) unknown yes
 
426 (RSLL.|.FYDD)
426,519

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes
 
430 (RNLL.|.IYEE)
430,520

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes
 
506 ()
506,1047

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16827 indirect unknown
 
519 ()
519,681

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16831 indirect unknown
 
522 (RSVL.|.SFES)
522,1141

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Marcinkiewicz M Seidah NG et al.:Mammalian subtilisin/kexin isoz... (S08.063) unknown none
 
530 (RNVL.|.GTES)
530,1147

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Seidah NG Pasquato A et al.:The proprotein convertase SKI-1... (S08.063) unknown yes
 
530 ()
530,1071

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16827 indirect unknown
 
560 ()
560,1177

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC16827 indirect unknown
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown
  • none

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?