Q14CN2: Calcium-activated chloride channel regulator 4 (Human)

Protein names
  • Calcium-activated chloride channel regulator 4
  • Calcium-activated chloride channel family member 4 Short=hCLCA4
  • Calcium-activated chloride channel protein 2 Short=CaCC-2 Short=hCaCC-2
  • CLCA4
Gene names CLCA4 (CaCC2)
Organism Homo sapiens
Protease Family M87 (MEROPS)
Protease ID M87.002 (MEROPS)
Chromosome 1

Sequence

        10         20         30         40         50         60 
MGLFRGFVFL LVLCLLHQSN TSFIKLNNNG FEDIVIVIDP SVPEDEKIIE QIEDMVTTAS 
        70         80         90        100        110        120 
TYLFEATEKR FFFKNVSILI PENWKENPQY KRPKHENHKH ADVIVAPPTL PGRDEPYTKQ 
       130        140        150        160        170        180 
FTECGEKGEY IHFTPDLLLG KKQNEYGPPG KLFVHEWAHL RWGVFDEYNE DQPFYRAKSK 
       190        200        210        220        230        240 
KIEATRCSAG ISGRNRVYKC QGGSCLSRAC RIDSTTKLYG KDCQFFPDKV QTEKASIMFM 
       250        260        270        280        290        300 
QSIDSVVEFC NEKTHNQEAP SLQNIKCNFR STWEVISNSE DFKNTIPMVT PPPPPVFSLL 
       310        320        330        340        350        360 
KISQRIVCLV LDKSGSMGGK DRLNRMNQAA KHFLLQTVEN GSWVGMVHFD STATIVNKLI 
       370        380        390        400        410        420 
QIKSSDERNT LMAGLPTYPL GGTSICSGIK YAFQVIGELH SQLDGSEVLL LTDGEDNTAS 
       430        440        450        460        470        480 
SCIDEVKQSG AIVHFIALGR AADEAVIEMS KITGGSHFYV SDEAQNNGLI DAFGALTSGN 
       490        500        510        520        530        540 
TDLSQKSLQL ESKGLTLNSN AWMNDTVIID STVGKDTFFL ITWNSLPPSI SLWDPSGTIM 
       550        560        570        580        590        600 
ENFTVDATSK MAYLSIPGTA KVGTWAYNLQ AKANPETLTI TVTSRAANSS VPPITVNAKM 
       610        620        630        640        650        660 
NKDVNSFPSP MIVYAEILQG YVPVLGANVT AFIESQNGHT EVLELLDNGA GADSFKNDGV 
       670        680        690        700        710        720 
YSRYFTAYTE NGRYSLKVRA HGGANTARLK LRPPLNRAAY IPGWVVNGEI EANPPRPEID 
       730        740        750        760        770        780 
EDTQTTLEDF SRTASGGAFV VSQVPSLPLP DQYPPSQITD LDATVHEDKI ILTWTAPGDN 
       790        800        810        820        830        840 
FDVGKVQRYI IRISASILDL RDSFDDALQV NTTDLSPKEA NSKESFAFKP ENISEENATH 
       850        860        870        880        890        900 
IFIAIKSIDK SNLTSKVSNI AQVTLFIPQA NPDDIDPTPT PTPTPTPDKS HNSGVNISTL 
       910    
VLSVIGSVVI VNFILSTTI

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
700
800
900
Chains:
 
 
 
 
N-termini:

NNNNN
 
C-termini:

CCCC
 
Cleavage sites:
  
 
Features:
  
 
Sequence variations:
      
 
Topology:
 
 
(MVHFD(350)|(351)STATI)
350,919

Cathepsin B (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Schilling O Biniossek ML et al.:Proteomic identification of pro... (C01.060) unknown none

Targeted features: ?

350,919,476,306 DOMAIN - VWFA. (306|476)
350,919,919,22 CHAIN - Calcium-activated chloride channel regulator 4. (22|919)
350,919,919,0 CHAIN - Calcium-activated chloride channel regulator 4, 30 kDa form. (0|919)
 
(PPLNR(697)|(698)AAYIP)
697,919

Calcium-activated chloride channel regulator 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Brett TJ Yurtsever Z et al.:Self-cleavage of human CLCA1 pr... (M87.001) unknown yes

Targeted features: ?

697,919,919,22 CHAIN - Calcium-activated chloride channel regulator 4. (22|919)
697,919,919,0 CHAIN - Calcium-activated chloride channel regulator 4, 30 kDa form. (0|919)
 
unknown-0IMGLFR...
0,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,919,919,0 CHAIN - Calcium-activated chloride channel regulator 4, 30 kDa form. (0|919)
 
unknown-22SFIKLN...
22,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

22,919,919,22 CHAIN - Calcium-activated chloride channel regulator 4. (22|919)
22,919,0,22 CHAIN - Calcium-activated chloride channel regulator 4, 110 kDa form. (22|0)
 
unknown-288MVTPPP...
288,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000263723 unknown unknown (unknown)
 
unknown-351STATIV...
351,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC4060 indirect unknown (unknown)
 
unknown-698AAYIPG...
698,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC8365 indirect unknown (unknown)
 

Protein C-Termini [export]

...LSTTI0-unknown
0,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,919,0,22 CHAIN - Calcium-activated chloride channel regulator 4, 110 kDa form. (22|0)
 
...MVHFD350-unknown
350,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC4060 indirect unknown (unknown)
 
...PPLNR697-unknown
697,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC8365 indirect unknown (unknown)
 
...LSTTI919-unknown
919,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

919,919,919,22 CHAIN - Calcium-activated chloride channel regulator 4. (22|919)
919,919,919,0 CHAIN - Calcium-activated chloride channel regulator 4, 30 kDa form. (0|919)
 
697 (PLNR.|.AAYI)
697,919

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Brett TJ Yurtsever Z et al.:Self-cleavage of human CLCA1 pr... (M87.001) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • none
  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?