Q15942: Zyxin (Human)

Protein names
  • Zyxin
  • Zyxin-2
  • ZYX
Gene names ZYX
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 7

Sequence

        10         20         30         40         50         60 
MAAPRPSPAI SVSVSAPAFY APQKKFGPVV APKPKVNPFR PGDSEPPPAP GAQRAQMGRV 
        70         80         90        100        110        120 
GEIPPPPPED FPLPPPPLAG DGDDAEGALG GAFPPPPPPI EESFPPAPLE EEIFPSPPPP 
       130        140        150        160        170        180 
PEEEGGPEAP IPPPPQPREK VSSIDLEIDS LSSLLDDMTK NDPFKARVSS GYVPPPVATP 
       190        200        210        220        230        240 
FSSKSSTKPA AGGTAPLPPW KSPSSSQPLP QVPAPAQSQT QFHVQPQPQP KPQVQLHVQS 
       250        260        270        280        290        300 
QTQPVSLANT QPRGPPASSP APAPKFSPVT PKFTPVASKF SPGAPGGSGS QPNQKLGHPE 
       310        320        330        340        350        360 
ALSAGTGSPQ PPSFTYAQQR EKPRVQEKQH PVPPPAQNQN QVRSPGAPGP LTLKEVEELE 
       370        380        390        400        410        420 
QLTQQLMQDM EHPQRQNVAV NELCGRCHQP LARAQPAVRA LGQLFHIACF TCHQCAQQLQ 
       430        440        450        460        470        480 
GQQFYSLEGA PYCEGCYTDT LEKCNTCGEP ITDRMLRATG KAYHPHCFTC VVCARPLEGT 
       490        500        510        520        530        540 
SFIVDQANRP HCVPDYHKQY APRCSVCSEP IMPEPGRDET VRVVALDKNF HMKCYKCEDC 
       550        560        570    
GKPLSIEADD NGCFPLDGHV LCRKCHTARA QT

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
Chains:
 
 
N-termini:

N
NNNN
NNNN
NN
 
C-termini:
CCCCC
 
Cleavage sites:
 
 
 
Features:
    
 
Sequence variations:
     
 
(DLEID(149)|(150)SLSSL)
149,572

Caspase-1 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Wells JA Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001) unknown none

Granzyme B (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Gevaert K Van Damme P et al.:Complementary positional proteo... (M14.017) unknown none

Targeted features: ?

149,572,572,2 CHAIN - Zyxin. (2|572)
 
unknown-1MAAPRP...
1,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000346417 unknown unknown (unknown)

Affected feature boundaries: ?

1,572,1,1 INIT_MET - Removed. (1|1)
 
acetylation-2AAPRPS...
2,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

2,572,572,2 CHAIN - Zyxin. (2|572)
2,572,2,2 MOD_RES - N-acetylalanine. (2|2)
 
unknown-13SVSAPA...
13,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_Etoposide direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 
unknown-57MGRVGE...
57,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000394158 unknown unknown (unknown)
 
unknown-150SLSSLL...
150,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC1306 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC12388 indirect unknown (unknown)
Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... unknown unknown (unknown)
 
unknown-150SLSSLL...
150,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_bortezomib direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_Etoposide direct yes 0.02 (ProteinProspector)
Wells apopotic_Jurkat_FasL direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1s_bort direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1SDBJurkat_Mix direct yes 0.02 (ProteinProspector)
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-158MTKNDP...
158,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000376642 unknown unknown (unknown)
 
unknown-237HVQSQT...
237,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 
unknown-247LANTQP...
247,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_bortezomib direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-248ANTQPR...
248,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-303SAGTGS...
303,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 

Protein C-Termini [export]

...DLEID149-unknown
149,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC1306 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC12388 indirect unknown (unknown)
 
...KNDPF164-unknown
164,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000400537 unknown unknown (unknown)
 
...SSSQP208-unknown
208,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000413467 unknown unknown (unknown)
 
...LEGTS481-unknown
481,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000403714 unknown unknown (unknown)
 
...ARAQT572-unknown
572,572

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

572,572,572,2 CHAIN - Zyxin. (2|572)
 
Filter by evidence: ?

Directness ?

  • unknown
  • direct
  • indirect

Physiological relevance ?

  • none
  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?