Q60813: Disintegrin and metalloproteinase domain-containing protein 1a (Mouse)

Protein names
  • Disintegrin and metalloproteinase domain-containing protein 1a (ADAM 1a)
  • Fertilin subunit alpha-a (ADAM 1a)
  • ADM1A
Gene names Adam1a (Adam1)
Organism Mus musculus
Protease Family M12 (MEROPS)
Protease ID M12.202 (MEROPS)
Chromosome 5

Sequence

        10         20         30         40         50         60 
MSVAAAGRGF ASSLSSPQIR RIALKEAKLT PHIWAALHWN LGLRLVPSVR VGILVLLIFL 
        70         80         90        100        110        120 
PSTFCDIGSV YNSSYETVIP ERLPGKGGKD PGGKVSYMLL MQGQKQLLHL EVKGHYPENN 
       130        140        150        160        170        180 
FPVYSYHNGI LRQEMPLLSQ DCHYEGYMEG VPGSFVSVNI CSGLRGVLIK EETSYGIEPM 
       190        200        210        220        230        240 
LSSKNFEHVL YTMEHQPVVS CSVTPKDSPG DTSHPPRSRK PDDLLVLTDW WSHTKYVEMF 
       250        260        270        280        290        300 
VVVNHQRFQM WGSNINETVQ AVMDIIALAN SFTRGINTEV VLVGLEIWTE GDPIEVPVDL 
       310        320        330        340        350        360 
QTTLRNFNFW RQEKLVGRVR HDVAHLIVGH RPGENEGQAF LRGACSGEFA AAVEAFHHED 
       370        380        390        400        410        420 
VLLFAALMAH ELGHNLGIQH DHPTCTCGPK HFCLMGEKIG KDSGFSNCSS DHFLRFLHDH 
       430        440        450        460        470        480 
RGACLLDEPG RQSRMRRAAN CGNGVVEDLE ECDCGSDCDS HPCCSPTCTL KEGAQCSEGL 
       490        500        510        520        530        540 
CCYNCTFKKK GSLCRPAEDV CDLPEYCDGS TQECPANSYM QDGTQCDRIY YCLGGWCKNP 
       550        560        570        580        590        600 
DKQCSRIYGY PARSAPEECY ISVNTKANRF GNCGHPTSAN FRYETCSDED VFCGKLVCTD 
       610        620        630        640        650        660 
VRYLPKVKPL HSLLQVPYGE DWCWSMDAYN ITDVPDDGDV QSGTFCAPNK VCMEYICTGR 
       670        680        690        700        710        720 
GVLQYNCEPQ EMCHGNGVCN NFKHCHCDAG FAPPDCSSPG NGGSVDSGPV GKPADRHLSL 
       730        740        750        760        770        780 
SFLAEESPDD KMEDEEVNLK VMVLVVPIFL VVLLCCLMLI AYLWSEVQEV VSPPSSSESS 
       790    
SSSSWSDSDS Q

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
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700
Chains:

 
 
N-termini:

NNN
 
C-termini:
CC
 
Cleavage sites:
 
 
 
 
 
 
Features:
     
 
Binding & active sites:
    
 
Sequence variations:
     
 
Topology:

   
 
(PRSRK(220)|(221)PDDLL)
220,791

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Targeted features: ?

220,791,740,0 TOPO_DOM - Extracellular (Potential). (0|740)
220,791,791,0 CHAIN - Disintegrin and metalloproteinase domain- containing protein 1a. (0|791)
 
unknown-0QMSVAA...
0,791

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,791,740,0 TOPO_DOM - Extracellular (Potential). (0|740)
0,791,791,0 CHAIN - Disintegrin and metalloproteinase domain- containing protein 1a. (0|791)
 
unknown-66DIGSVY...
66,791

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

66,791,0,66 PROPEP - Potential. (66|0)
 
unknown-221PDDLLV...
221,791

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34733 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34757 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34761 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34772 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC32223 indirect unknown (unknown)
 

Protein C-Termini [export]

...PRSRK220-unknown
220,791

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34733 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34757 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34761 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC34772 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC32223 indirect unknown (unknown)
 
...DSDSQ791-unknown
791,791

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

791,791,791,762 TOPO_DOM - Cytoplasmic (Potential). (762|791)
791,791,791,0 CHAIN - Disintegrin and metalloproteinase domain- containing protein 1a. (0|791)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?