Q61316: Heat shock 70 kDa protein 4 (Mouse)

Protein names
  • Heat shock 70 kDa protein 4
  • Heat shock 70-related protein APG-2
  • HSP74
Gene names Hspa4 (Apg2, Hsp110)
Organism Mus musculus
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome (Not Available)

Sequence

        10         20         30         40         50         60 
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA AAKSQVISNA 
        70         80         90        100        110        120 
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 
       130        140        150        160        170        180 
LLSKLKETAE SVLKKPVVDC VVSVPSFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 
       190        200        210        220        230        240 
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL 
       250        260        270        280        290        300 
VNHFCEEFGK KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT 
       310        320        330        340        350        360 
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 
       370        380        390        400        410        420 
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGLSDCEVF 
       430        440        450        460        470        480 
PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 
       490        500        510        520        530        540 
KVRVNVHGIF SVSSAALVEV HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT 
       550        560        570        580        590        600 
PAENKAESEE METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIEHTLWQL DREMLALYTE 
       610        620        630        640        650        660 
NEGKMIMQDK LEKERNDAKN AVEEYVYEMR DKLSGEYEKF VSEDDRNTFT LKLEDTENWL 
       670        680        690        700        710        720 
YEDGEDQPKQ VYVDKLAELK SLGQPIKTRF QESEERPKLF EELGKQIQQY MKVISSFKNK 
       730        740        750        760        770        780 
EDQYEHLDAA DVTKVEKSTN EAMEWMNSKL NLQNKQSLTV DPVVKTKEIE AKIKELTSIC 
       790        800        810        820        830        840 
SPIISKPKPK VEPPKEEPKH AEQNGPVDGQ GDNPGSQAAE HGADTAVPSD GDKKLPEMDI 
   
D

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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800
Chains:
 
 
N-termini:

NNNNNNNNN
N
 
C-termini:
CCCCCCCC
CC
 
Cleavage sites:
        
  
 
 
Modifications:
         
 
(GGIET(25)|(26)IANEY)
25,841

Cathepsin E (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops CATE_MOUSE -> HSP74_MOUSE @25 unknown yes

Targeted features: ?

25,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(QLPTG(97)|(98)LTGIK)
97,841

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Targeted features: ?

97,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(ALAYG(182)|(183)IYKQD)
182,841

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown none

Targeted features: ?

182,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(EDIYA(337)|(338)VEIVG)
337,841

Cathepsin E (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops CATE_MOUSE -> HSP74_MOUSE @337 unknown yes

Targeted features: ?

337,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)

Affected feature boundaries: ?

337,841,336,336 MOD_RES - Phosphotyrosine. (336|336)
 
(EKISK(356)|(357)FFGKE)
356,841

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM auf dem Keller U et al.:A statistics-based platform for... (M10.003) unknown none

Targeted features: ?

356,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(CALQC(380)|(381)AILSP)
380,841

Cathepsin E (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops CATE_MOUSE -> HSP74_MOUSE @380 unknown yes

Targeted features: ?

380,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(EMLAL(597)|(598)YTENE)
597,841

Cathepsin E (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops CATE_MOUSE -> HSP74_MOUSE @597 unknown yes

Targeted features: ?

597,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(YVDKL(676)|(677)AELKS)
676,841

Cathepsin E (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops CATE_MOUSE -> HSP74_MOUSE @676 unknown yes

Cathepsin D (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops CATD_MOUSE -> HSP74_MOUSE @676 unknown yes

Targeted features: ?

676,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
(DKLAE(678)|(679)LKSLG)
678,841

Matrix metalloproteinase-9 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

72 kDa type IV collagenase (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Overall CM Prudova A et al.:Multiplex N-terminome analysis ... (M10.004) unknown none

Targeted features: ?

678,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
unknown-1MSVVGI...
1,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
unknown-26IANEYS...
26,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30504 indirect unknown (unknown)
 
unknown-98LTGIKV...
98,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33950 indirect unknown (unknown)
 
unknown-183IYKQDL...
183,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33951 indirect unknown (unknown)
 
unknown-338VEIVGG...
338,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30505 indirect unknown (unknown)
 
unknown-357FFGKEL...
357,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33952 indirect unknown (unknown)
 
unknown-381AILSPA...
381,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30506 indirect unknown (unknown)
 
unknown-598YTENEG...
598,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30507 indirect unknown (unknown)
 
unknown-677AELKSL...
677,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30508 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC29155 indirect unknown (unknown)
 
unknown-679LKSLGQ...
679,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34633 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC33953 indirect unknown (unknown)
 

Protein C-Termini [export]

...GGIET25-unknown
25,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30504 indirect unknown (unknown)
 
...QLPTG97-unknown
97,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33950 indirect unknown (unknown)
 
...ALAYG182-unknown
182,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33951 indirect unknown (unknown)
 
...EDIYA337-unknown
337,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30505 indirect unknown (unknown)
 
...EKISK356-unknown
356,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC33952 indirect unknown (unknown)
 
...CALQC380-unknown
380,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30506 indirect unknown (unknown)
 
...EMLAL597-unknown
597,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30507 indirect unknown (unknown)
 
...YVDKL676-unknown
676,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC30508 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC29155 indirect unknown (unknown)
 
...DKLAE678-unknown
678,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC34633 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC33953 indirect unknown (unknown)
 
...EMDID841-unknown
841,841

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

841,841,841,1 CHAIN - Heat shock 70 kDa protein 4. (1|841)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • none
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?