Q6NZY4: Zinc finger CCHC domain-containing protein 8 (Human)

Protein names
  • Zinc finger CCHC domain-containing protein 8
  • TRAMP-like complex RNA-binding factor ZCCHC8
  • ZCHC8
Gene names ZCCHC8
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 12

Isoforms

  • Isoform 2 of Zinc finger CCHC domain-containing protein 8 (Q6NZY4-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MAAEVYFGDL ELFEPFDHPE ESIPKPVHTR FKDDDGDEED ENGVGDAELR ERLRQCEETI 
        70         80         90        100        110        120 
EQLRAENQEL KRKLNILTRP SGILVNDTKL DGPILQILFM NNAISKQYHQ EIEEFVSNLV 
       130        140        150        160        170        180 
KRFEEQQKND VEKTSFNLLP QPSSIVLEED HKVEESCAIK NNKEAFSVVG SVLYFTNFCL 
       190        200        210        220        230        240 
DKLGQPLLNE NPQLSEGWEI PKYHQVFSHI VSLEGQEIQV KAKRPKPHCF NCGSEEHQMK 
       250        260        270        280        290        300 
DCPMPRNAAR ISEKRKEYMD ACGEANNQNF QQRYHAEEVE ERFGRFKPGV ISEELQDALG 
       310        320        330        340        350        360 
VTDKSLPPFI YRMRQLGYPP GWLKEAELEN SGLALYDGKD GTDGETEVGE IQQNKSVTYD 
       370        380        390        400        410        420 
LSKLVNYPGF NISTPRGIPD EWRIFGSIPM QACQQKDVFA NYLTSNFQAP GVKSGNKRSS 
       430        440        450        460        470        480 
SHSSPGSPKK QKNESNSAGS PADMELDSDM EVPHGSQSSE SFQFQPPLPP DTPPLPRGTP 
       490        500        510        520        530        540 
PPVFTPPLPK GTPPLTPSDS PQTRTASGAV DEDALTLEEL EEQQRRIWAA LEQAESVNSD 
       550        560        570        580        590        600 
SDVPVDTPLT GNSVASSPCP NELDLPVPEG KTSEKQTLDE PEVPEIFTKK SEAGHASSPD 
       610        620        630        640        650        660 
SEVTSLCQKE KAELAPVNTE GALLDNGSVV PNCDISNGGS QKLFPADTSP STATKIHSPI 
       670        680        690        700    
PDMSKFATGI TPFEFENMAE STGMYLRIRS LLKNSPRNQQ KNKKASE

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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700
Chains:
 
 
N-termini:

N
NNN
NN
NN
 
C-termini:
CC
 
Cleavage sites:
 
 
Features:
 
 
Binding & active sites:
 
 
Sequence variations:
 
       
 
Topology:
  
 
Modifications:
     
 
(AVDED(513)|(514)ALTLE)
513,707

Granzyme B (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Gevaert K Van Damme P et al.:Analysis of protein processing ... (S01.010) unknown yes

Targeted features: ?

513,707,707,2 CHAIN - Zinc finger CCHC domain-containing protein 8. (2|707)
 
unknown-1MAAEVY...
1,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,707,1,1 INIT_MET - Removed. (1|1)
1,707,238,1 VAR_SEQ - Missing (in isoform 2). (1|238)
 
acetylation-2AAEVYF...
2,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

2,707,707,2 CHAIN - Zinc finger CCHC domain-containing protein 8. (2|707)
2,707,2,2 MOD_RES - N-acetylalanine. (2|2)
 
unknown-239MKDCPM...
239,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt95040 indirect unknown (unknown)
 
unknown-344GETEVG...
344,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1SDBJurkat_Mix direct yes 0.02 (ProteinProspector)
 
unknown-344GETEVG...
344,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt171622 indirect unknown (unknown)
 
unknown-505TASGAV...
505,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1SDBJurkat_Mix direct yes 0.02 (ProteinProspector)
 
unknown-505TASGAV...
505,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt173827 indirect unknown (unknown)
 
unknown-514ALTLEE...
514,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC12589 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt149244 indirect unknown (unknown)
 

Protein C-Termini [export]

...AVDED513-unknown
513,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC12589 indirect unknown (unknown)
 
...KKASE707-unknown
707,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt90658 indirect unknown (unknown)
Gevaert K. Van Damme P et al.: Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)
Gevaert K. Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

707,707,707,2 CHAIN - Zinc finger CCHC domain-containing protein 8. (2|707)
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect
  • direct

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?