Q80YN4: Atrial natriuretic peptide-converting enzyme (Rat)

Protein names
  • Atrial natriuretic peptide-converting enzyme
  • Corin
  • Pro-ANP-converting enzyme;
Gene names Corin
Organism Rattus norvegicus
Protease Family I93 (MEROPS)
Protease ID I93.001 (MEROPS)
Chromosome (Not Available)

Sequence

        10         20         30         40         50         60 
MGRVSFNVRV SSVRRARCSC PGRCYLSCRV PPTTALHALN GFGRAGVLGE TAGGTVGLGP 
        70         80         90        100        110        120 
SGTRGFLSGS KFQASGSLKD CFGAPPAPDV LRADSSVGEG CPQKLVTANL LRFLLLVLIP 
       130        140        150        160        170        180 
CICALIVLLA ILLSFVGTLK KVYFKSNDSE PLVTDGEVRV PGVIHVNRYE NTGAPSMPPS 
       190        200        210        220        230        240 
QSIPAWTPRA PSLEDQSHGN TSTCVNITHR QCQILPYHST LAPLLPIVKN MDTEKFLKFF 
       250        260        270        280        290        300 
TYLHRLGCYQ HILLFGCSLA FPKCIVDGDD RHGLLPCRSF CEAAKEGCES VLGMVNSSWP 
       310        320        330        340        350        360 
DSLRCSQFRY HTENNSDASR ICFSLQQEHG KQSLCGGGES FLCTSGLCIS KKLQCNGYND 
       370        380        390        400        410        420 
CDDWSDEAHC NCSEDLFHCG TGKCLHHSLV CDGYDDCGDL SDEQNCDCNL TKEHRCGDGR 
       430        440        450        460        470        480 
CIAAEWVCDG DHDCVDKSDE VNCSCPSQGL VECRSGQCIP STFQCDGDED CKDGSDEENC 
       490        500        510        520        530        540 
SDRPTPCPGG DRGCLDSSCV ESCAGSSLCD SDSSLSNCSH CEPITLELCM NLPYNLTHYP 
       550        560        570        580        590        600 
NYLGHRTQKE ASISWESALF PALVQTNCYK YLMFFACTIL VPKCDVNTGQ RVPPCRLLCE 
       610        620        630        640        650        660 
HSKERCESVL GIVGLQWPED TDCSQFPEQS SDNQTCLLPN EDVEECSPSH FKCRSGRCVL 
       670        680        690        700        710        720 
GSRRCDGQAD CDDDSDEENC GCKERDLWEC PLNKQCLKHT LICDGFPDCS DSMDEKNCSF 
       730        740        750        760        770        780 
CQDDELECAN HECVPRDLWC DGWTDCSDSS DEWGCVTLSK NGNSSSFLTV HRSARDHHVC 
       790        800        810        820        830        840 
ADGWQETLSQ LACRQMGLGE PSVTELVQGQ EGQQWLRLHS SWENLNGSTL QELLVHRRSC 
       850        860        870        880        890        900 
PSGSEISLLC TKQDCGRRPA ARMNKRILGG RTSRPGRWPW QCSLQSEPSG HICGCVLIAK 
       910        920        930        940        950        960 
KWVLTVAHCF EGREDADVWK VVFGINNLDH PSGFMQTRFV KTILLHPRYS RAVVDYDISV 
       970        980        990       1000       1010       1020 
VELSDDINET SYVRPVCLPS PREFLEPDTY CYITGWGHMG NKMPFKLQEG EVRIIPLEQC 
      1030       1040       1050       1060       1070       1080 
QSYFDMKTIT NRMICAGYES GTVDSCMIDS GGPLVCERPG GQWTLFGLTS WGSVCFSKVL 
      1090       1100       1110    
GPGVYSNVSY FVDWIERQIY IQTFLQKKSQ G

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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Chains:
 
 
  
 
N-termini:

N
NN
 
C-termini:
CC
 
Binding & active sites:
   
 
Sequence variations:
      
 
Topology:
   
 
unknown-0GMGRVS...
0,1111

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,1111,866,0 CHAIN - Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment. {ECO:0000250}. (0|866)
 
unknown-1MGRVSF...
1,1111

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,1111,1111,1 CHAIN - Atrial natriuretic peptide-converting enzyme. (1|1111)
1,1111,866,1 CHAIN - Atrial natriuretic peptide-converting enzyme, N-terminal propeptide. {ECO:0000305}. (1|866)
1,1111,112,1 TOPO_DOM - Cytoplasmic. {ECO:0000255}. (1|112)
 
unknown-867ILGGRT...
867,1111

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

867,1111,1111,867 CHAIN - Atrial natriuretic peptide-converting enzyme, activated protease fragment. {ECO:0000305}. (867|1111)
867,1111,1100,867 DOMAIN - Peptidase S1. {ECO:0000255|PROSITE- ProRule:PRU00274}. (867|1100)
 

Protein C-Termini [export]

...RMNKR866-unknown
866,1111

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

866,1111,866,866 MUTAGEN - R->A: Impairs proteolytic processing and activation. {ECO:0000269|PubMed:17660514}. (866|866)
866,1111,866,1 CHAIN - Atrial natriuretic peptide-converting enzyme, N-terminal propeptide. {ECO:0000305}. (1|866)
866,1111,866,0 CHAIN - Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment. {ECO:0000250}. (0|866)
 
...KKSQG1111-unknown
1111,1111

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1111,1111,1111,1 CHAIN - Atrial natriuretic peptide-converting enzyme. (1|1111)
1111,1111,1111,867 CHAIN - Atrial natriuretic peptide-converting enzyme, activated protease fragment. {ECO:0000305}. (867|1111)
1111,1111,1111,134 TOPO_DOM - Extracellular. {ECO:0000255}. (134|1111)
 
Filter by evidence: ?

Directness ?

  • unknown

Physiological relevance ?

  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?