Q8TCT7: Signal peptide peptidase-like 2B (Human)

Protein names
  • Signal peptide peptidase-like 2B (SPP-like 2B)
  • Intramembrane protease 4 Short=IMP-4 (SPP-like 2B)
  • Presenilin homologous protein 4 Short=PSH4 (SPP-like 2B)
  • Presenilin-like protein 1 (SPP-like 2B)
  • SPP2B
Gene names SPPL2B (IMP4, KIAA1532, PSL1)
Organism Homo sapiens
Protease Family A22 (MEROPS)
Protease ID A22.004 (MEROPS)
Chromosome 19

Isoforms

  • Isoform 2 of Signal peptide peptidase-like 2B (Q8TCT7-2): sequence view | extended view
  • Isoform 3 of Signal peptide peptidase-like 2B (Q8TCT7-3): sequence view | extended view
  • Isoform 4 of Signal peptide peptidase-like 2B (Q8TCT7-4): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MAAAVAAALA RLLAAFLLLA AQVACEYGMV HVVSQAGGPE GKDYCILYNP QWAHLPHDLS 
        70         80         90        100        110        120 
KASFLQLRNW TASLLCSAAD LPARGFSNQI PLVARGNCTF YEKVRLAQGS GARGLLIVSR 
       130        140        150        160        170        180 
ERLVPPGGNK TQYDEIGIPV ALLSYKDMLD IFTRFGRTVR AALYAPKEPV LDYNMVIIFI 
       190        200        210        220        230        240 
MAVGTVAIGG YWAGSRDVKK RYMKHKRDDG PEKQEDEAVD VTPVMTCVFV VMCCSMLVLL 
       250        260        270        280        290        300 
YYFYDLLVYV VIGIFCLASA TGLYSCLAPC VRRLPFGKCR IPNNSLPYFH KRPQARMLLL 
       310        320        330        340        350        360 
ALFCVAVSVV WGVFRNEDQW AWVLQDALGI AFCLYMLKTI RLPTFKACTL LLLVLFLYDI 
       370        380        390        400        410        420 
FFVFITPFLT KSGSSIMVEV ATGPSDSATR EKLPMVLKVP RLNSSPLALC DRPFSLLGFG 
       430        440        450        460        470        480 
DILVPGLLVA YCHRFDIQVQ SSRVYFVACT IAYGVGLLVT FVALALMQRG QPALLYLVPC 
       490        500        510        520        530        540 
TLVTSCAVAL WRRELGVFWT GSGFAKVLPP SPWAPAPADG PQPPKDSATP LSPQPPSEEP 
       550        560        570        580        590    
ATSPWPAEQS PKSRTSEEMG AGAPMREPGS PAESEGRDQA QPSPVTQPGA SA

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
Chains:
 
 
N-termini:

NN
 
C-termini:
CC
 
Features:
   
 
Binding & active sites:
  
 
Sequence variations:
  
   
 
 
unknown-1MAAAVA...
1,592

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt90505 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt90506 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt90507 indirect unknown (unknown)

Affected feature boundaries: ?

1,592,25,1 SIGNAL - Potential. (1|25)
 
unknown-26EYGMVH...
26,592

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt114101 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt114102 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt114103 indirect unknown (unknown)

Affected feature boundaries: ?

26,592,592,26 CHAIN - Signal peptide peptidase-like 2B. (26|592)
26,592,174,26 TOPO_DOM - Lumenal (Potential). (26|174)
 

Protein C-Termini [export]

...RNEDQ319-unknown
319,592

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TCt86124 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt86123 indirect unknown (unknown)

Affected feature boundaries: ?

319,592,319,315 TOPO_DOM - Lumenal (Potential). (315|319)
 
...PGASA592-unknown
592,592

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

592,592,592,26 CHAIN - Signal peptide peptidase-like 2B. (26|592)
592,592,592,492 TOPO_DOM - Cytoplasmic (Potential). (492|592)
592,592,592,320 VAR_SEQ - Missing (in isoform 2 and isoform 3). (320|592)
592,592,592,512 VAR_SEQ - Missing (in isoform 4). (512|592)
 
34 (LFLS.|.LFSF)
34,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004) unknown yes
 
36 (LSLF.|.SFLI)
36,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) unknown yes
 
39 (FSFL.|.IVAG)
39,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004) unknown yes
 
49 (TLFC.|.LLHF)
49,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004) unknown yes
 
51 (FCLL.|.HFGV)
51,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?