Q8TCT8: Signal peptide peptidase-like 2A (Human)

Protein names
  • Signal peptide peptidase-like 2A (SPP-like 2A)
  • Intramembrane protease 3 Short=IMP-3 (SPP-like 2A)
  • Presenilin-like protein 2 (SPP-like 2A)
  • SPP2A
Gene names SPPL2A (IMP3, PSL2)
Organism Homo sapiens
Protease Family A22 (MEROPS)
Protease ID A22.007 (MEROPS)
Chromosome 15

Sequence

        10         20         30         40         50         60 
MGPQRRLSPA GAALLWGFLL QLTAAQEAIL HASGNGTTKD YCMLYNPYWT ALPSTLENAT 
        70         80         90        100        110        120 
SISLMNLTST PLCNLSDIPP VGIKSKAVVV PWGSCHFLEK ARIAQKGGAE AMLVVNNSVL 
       130        140        150        160        170        180 
FPPSGNRSEF PDVKILIAFI SYKDFRDMNQ TLGDNITVKM YSPSWPNFDY TMVVIFVIAV 
       190        200        210        220        230        240 
FTVALGGYWS GLVELENLKA VTTEDREMRK KKEEYLTFSP LTVVIFVVIC CVMMVLLYFF 
       250        260        270        280        290        300 
YKWLVYVMIA IFCIASAMSL YNCLAALIHK IPYGQCTIAC RGKNMEVRLI FLSGLCIAVA 
       310        320        330        340        350        360 
VVWAVFRNED RWAWILQDIL GIAFCLNLIK TLKLPNFKSC VILLGLLLLY DVFFVFITPF 
       370        380        390        400        410        420 
ITKNGESIMV ELAAGPFGNN EKLPVVIRVP KLIYFSVMSV CLMPVSILGF GDIIVPGLLI 
       430        440        450        460        470        480 
AYCRRFDVQT GSSYIYYVSS TVAYAIGMIL TFVVLVLMKK GQPALLYLVP CTLITASVVA 
       490        500        510        520    
WRRKEMKKFW KGNSYQMMDH LDCATNEENP VISGEQIVQQ 

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
Chains:
 
 
N-termini:
NN
 
C-termini:
CC
 
Features:
    
 
Binding & active sites:
  
 
Sequence variations:
       
 
unknown-26QEAILH...
26,520

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

26,520,520,26 CHAIN - Signal peptide peptidase-like 2A. (26|520)
26,520,172,26 TOPO_DOM - Lumenal (Potential). (26|172)
 
unknown-43MLYNPY...
43,520

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000453932 unknown unknown (unknown)
 

Protein C-Termini [export]

...GYWSG191-unknown
191,520

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation Ensembl inferred from ensembl protein ENSP00000453932 unknown unknown (unknown)
 
...QIVQQ520-unknown
520,520

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

520,520,520,26 CHAIN - Signal peptide peptidase-like 2A. (26|520)
520,520,520,482 TOPO_DOM - Cytoplasmic (Potential). (482|520)
 
34 (LFLS.|.LFSF)
34,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) unknown yes
 
36 (LSLF.|.SFLI)
36,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) unknown yes
 
39 (FSFL.|.IVAG)
39,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) unknown yes
 
49 (TLFC.|.LLHF)
49,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) unknown yes
 
51 (FCLL.|.HFGV)
51,233

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Haass C Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?