Q99542: Matrix metalloproteinase-19 (Human)

Protein names
  • Matrix metalloproteinase-19 (MMP-19)
  • Matrix metalloproteinase RASI (MMP-19)
  • Matrix metalloproteinase-18 Short=MMP-18 (MMP-19)
  • MMP19
Gene names MMP19 (MMP18, RASI)
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.021 (MEROPS)
Chromosome 12

Isoforms

  • Isoform 2 of Matrix metalloproteinase-19 (Q99542-3): sequence view | extended view
  • Isoform 3 of Matrix metalloproteinase-19 (Q99542-4): sequence view | extended view
  • Isoform 4 of Matrix metalloproteinase-19 (Q99542-5): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MNCQQLWLGF LLPMTVSGRV LGLAEVAPVD YLSQYGYLQK PLEGSNNFKP EDITEALRAF 
        70         80         90        100        110        120 
QEASELPVSG QLDDATRARM RQPRCGLEDP FNQKTLKYLL LGRWRKKHLT FRILNLPSTL 
       130        140        150        160        170        180 
PPHTARAALR QAFQDWSNVA PLTFQEVQAG AADIRLSFHG RQSSYCSNTF DGPGRVLAHA 
       190        200        210        220        230        240 
DIPELGSVHF DEDEFWTEGT YRGVNLRIIA AHEVGHALGL GHSRYSQALM APVYEGYRPH 
       250        260        270        280        290        300 
FKLHPDDVAG IQALYGKKSP VIRDEEEEET ELPTVPPVPT EPSPMPDPCS SELDAMMLGP 
       310        320        330        340        350        360 
RGKTYAFKGD YVWTVSDSGP GPLFRVSALW EGLPGNLDAA VYSPRTQWIH FFKGDKVWRY 
       370        380        390        400        410        420 
INFKMSPGFP KKLNRVEPNL DAALYWPLNQ KVFLFKGSGY WQWDELARTD FSSYPKPIKG 
       430        440        450        460        470        480 
LFTGVPNQPS AAMSWQDGRV YFFKGKVYWR LNQQLRVEKG YPRNISHNWM HCRPRTIDTT 
       490        500    
PSGGNTTPSG TGITLDTTLS ATETTFEY

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
Chains:
 
 
N-termini:

NNN
 
C-termini:
C
 
Features:
  
 
 
Binding & active sites:
     
 
Sequence variations:
 
  
    
   
  
  
 
Topology:
    
 
unknown-1MNCQQL...
1,508

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt81289 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt81290 indirect unknown (unknown)

Affected feature boundaries: ?

1,508,286,1 VAR_SEQ - Missing (in isoform 2). (1|286)
1,508,18,1 SIGNAL - Potential. (1|18)
 
unknown-19RVLGLA...
19,508

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt112146 indirect unknown (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt112147 indirect unknown (unknown)

Affected feature boundaries: ?

19,508,97,19 PROPEP - (19|97)
 
unknown-98YLLLGR...
98,508

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TNt115853 indirect unknown (unknown)

Affected feature boundaries: ?

98,508,508,98 CHAIN - Matrix metalloproteinase-19. (98|508)
 

Protein C-Termini [export]

...TTFEY508-unknown
508,508

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt76906 indirect unknown (unknown)

Affected feature boundaries: ?

508,508,508,64 VAR_SEQ - Missing (in isoform 3). (64|508)
508,508,508,388 VAR_SEQ - Missing (in isoform 4). (388|508)
508,508,508,98 CHAIN - Matrix metalloproteinase-19. (98|508)
 
92 (ATLK.|.AMRT)
92,707

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Knauper V Stracke JO et al.:Biochemical characterization of... (M10.021) unknown yes
 
108 (RAVT.|.YSRS)
108,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
109 (AVTY.|.SRSR)
109,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
110 (VTYS.|.RSRY)
110,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
111 (TYSR.|.SRYL)
111,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
108 ()
108,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21702 indirect unknown
 
109 ()
109,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21705 indirect unknown
 
110 ()
110,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21708 indirect unknown
 
111 ()
111,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21711 indirect unknown
 
108 ()
108,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21702 indirect unknown
 
109 ()
109,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21705 indirect unknown
 
110 ()
110,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21708 indirect unknown
 
111 ()
111,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21711 indirect unknown
 
360 (IPEN.|.FFGV)
360,2415

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops MMP19_HUMAN -> PGCA_HUMAN @360 unknown yes
 
360 ()
360,2316

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21699 indirect unknown
 
360 ()
360,2377

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21699 indirect unknown
 
1105 ()
1105,1114

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21696 indirect unknown
 
1238 (PDNT.|.LGVD)
1238,1247

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sedlacek R Titz B et al.:Activity of MMP-19 inhibits cap... (M10.021) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?