Q9NPA2: Matrix metalloproteinase-25 (Human)

Protein names
  • Matrix metalloproteinase-25 (MMP-25)
  • Leukolysin (MMP-25)
  • Membrane-type matrix metalloproteinase 6 Short=MT-MMP 6 Short=MTMMP6 (MMP-25)
  • Membrane-type-6 matrix metalloproteinase Short=MT6-MMP Short=MT6MMP (MMP-25)
  • MMP25
Gene names MMP25 (MMP20, MMPL1, MT6MMP)
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.024 (MEROPS)
Chromosome 16

Sequence

        10         20         30         40         50         60 
MRLRLRLLAL LLLLLAPPAR APKPSAQDVS LGVDWLTRYG YLPPPHPAQA QLQSPEKLRD 
        70         80         90        100        110        120 
AIKVMQRFAG LPETGRMDPG TVATMRKPRC SLPDVLGVAG LVRRRRRYAL SGSVWKKRTL 
       130        140        150        160        170        180 
TWRVRSFPQS SQLSQETVRV LMSYALMAWG MESGLTFHEV DSPQGQEPDI LIDFARAFHQ 
       190        200        210        220        230        240 
DSYPFDGLGG TLAHAFFPGE HPISGDTHFD DEETWTFGSK DGEGTDLFAV AVHEFGHALG 
       250        260        270        280        290        300 
LGHSSAPNSI MRPFYQGPVG DPDKYRLSQD DRDGLQQLYG KAPQTPYDKP TRKPLAPPPQ 
       310        320        330        340        350        360 
PPASPTHSPS FPIPDRCEGN FDAIANIRGE TFFFKGPWFW RLQPSGQLVS PRPARLHRFW 
       370        380        390        400        410        420 
EGLPAQVRVV QAAYARHRDG RILLFSGPQF WVFQDRQLEG GARPLTELGL PPGEEVDAVF 
       430        440        450        460        470        480 
SWPQNGKTYL VRGRQYWRYD EAAARPDPGY PRDLSLWEGA PPSPDDVTVS NAGDTYFFKG 
       490        500        510        520        530        540 
AHYWRFPKNS IKTEPDAPQP MGPNWLDCPA PSSGPRAPRP PKATPVSETC DCQCELNQAA 
       550        560    
GRWPAPIPLL LLPLLVGGVA SR

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
Chains:
 
 
N-termini:
NN
 
C-termini:
CC
 
Cleavage sites:
 
 
 
Features:
  
  
 
Binding & active sites:
     
 
Sequence variations:
 
 
Topology:
    
 
Modifications:
 
 
(RRRRR(107)|(108)YALSG)
107,562

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Affected feature boundaries: ?

107,562,107,103 COMPBIAS - Poly-Arg. (103|107)
107,562,539,108 CHAIN - Matrix metalloproteinase-25. (108|539)
107,562,107,22 PROPEP - By similarity. (22|107)
 
unknown-22PKPSAQ...
22,562

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

22,562,107,22 PROPEP - By similarity. (22|107)
 
unknown-108YALSGS...
108,562

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26660 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9831 indirect unknown (unknown)

Affected feature boundaries: ?

108,562,539,108 CHAIN - Matrix metalloproteinase-25. (108|539)
 

Protein C-Termini [export]

...RRRRR107-unknown
107,562

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26660 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9831 indirect unknown (unknown)

Affected feature boundaries: ?

107,562,107,103 COMPBIAS - Poly-Arg. (103|107)
107,562,107,22 PROPEP - By similarity. (22|107)
 
...ELNQA539-unknown
539,562

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

539,562,539,108 CHAIN - Matrix metalloproteinase-25. (108|539)
539,562,539,539 LIPID - GPI-anchor amidated alanine (Potential). (539|539)
 
4 (MSLQ.|.LRSS)
4,132

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
9 (RSSA.|.RIPS)
9,132

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
4 (MARA.|.TLSA)
4,107

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
4 (MNAK.|.VVVV)
4,93

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
4 (MKAS.|.AALL)
4,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
4 (MKVS.|.AALL)
4,99

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
4 (MKVS.|.EAAL)
4,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
4 (MKVS.|.AVLL)
4,98

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
72 (LGKE.|.ICAD)
72,98

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
6 (LCVT.|.VLSL)
6,92

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
7 (LSSR.|.AARV)
7,114

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
10 (ALSC.|.LMLV)
10,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
20 (LGSQ.|.ARVT)
20,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
25 (RVTK.|.DAET)
25,120

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
15 ()
15,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21827 indirect unknown
 
90 ()
90,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21833 indirect unknown
 
123 ()
123,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21847 indirect unknown
 
142 ()
142,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21852 indirect unknown
 
158 ()
158,160

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21857 indirect unknown
 
15 ()
15,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21827 indirect unknown
 
90 ()
90,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21833 indirect unknown
 
102 ()
102,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21838 indirect unknown
 
109 ()
109,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21841 indirect unknown
 
111 ()
111,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21844 indirect unknown
 
134 ()
134,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21847 indirect unknown
 
153 ()
153,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21852 indirect unknown
 
169 ()
169,171

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21857 indirect unknown
 
15 ()
15,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21827 indirect unknown
 
116 ()
116,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21833 indirect unknown
 
149 ()
149,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21847 indirect unknown
 
168 ()
168,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21852 indirect unknown
 
184 ()
184,186

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21857 indirect unknown
 
15 ()
15,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21827 indirect unknown
 
116 ()
116,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21833 indirect unknown
 
128 ()
128,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21838 indirect unknown
 
135 ()
135,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21841 indirect unknown
 
137 ()
137,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21844 indirect unknown
 
160 ()
160,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21847 indirect unknown
 
179 ()
179,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21852 indirect unknown
 
195 ()
195,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21857 indirect unknown
 
16 ()
16,610

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21862 indirect unknown
 
59 ()
59,610

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21864 indirect unknown
 
20 ()
20,137

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC35035 indirect unknown
 
25 ()
25,137

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC35037 indirect unknown
 
24 (AQFI.|.NDAE)
24,113

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
26 (FIND.|.AETE)
26,113

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
28 (LLLL.|.TPPG)
28,114

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
33 ()
33,584

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21864 indirect unknown
 
66 (ESCN.|.LFVL)
66,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Nie J et al.:Direct activation of pro-matrix... (M10.024) unknown yes
 
109 (DVAN.|.YNFF)
109,660

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Nie J et al.:Direct activation of pro-matrix... (M10.024) unknown yes
 
90 (KKWE.|.KQVS)
90,125

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
Overall Lab recMMP-Chemokine_AStarr2012B direct unknown
 
108 (RAVT.|.YSRS)
108,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
109 (AVTY.|.SRSR)
109,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
111 (TYSR.|.SRYL)
111,335

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sidenius N Andolfo A et al.:Metalloproteases cleave the uro... (S01.131) unknown yes
 
108 ()
108,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21867 indirect unknown
 
109 ()
109,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21870 indirect unknown
 
111 ()
111,290

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21873 indirect unknown
 
108 ()
108,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21867 indirect unknown
 
109 ()
109,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21870 indirect unknown
 
111 ()
111,281

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21873 indirect unknown
 
148 (GSKY.|.LATA)
148,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
223 (VVHF.|.FKNI)
223,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
235 (TPPP.|.SQGK)
235,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
242 (KGRG.|.LSLS)
242,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
244 (RGLS.|.LSRF)
244,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
267 (RASD.|.YKSA)
267,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
286 (TLSK.|.IFKL)
286,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
302 (SPMA.|.RR)
302,304

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Shiryaev SA et al.:Matrix metalloproteinase proteo... (M10.006) unknown yes
 
148 ()
148,197

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from isoform by sequence similarity TopFIND inferred from TC21827 indirect unknown
 
376 (GAMF.|.LEAI)
376,418

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Nie J et al.:Rapid inactivation of alpha-1-p... (M10.024) unknown yes
 
381 (EAIP.|.MSIP)
381,418

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Pei D Nie J et al.:Rapid inactivation of alpha-1-p... (M10.024) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • direct
  • indirect

Physiological relevance ?

  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown
  • I no other proteolytic activities present

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?