Q9NTG7: NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Human)

Protein names
  • NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3)
  • Regulatory protein SIR2 homolog 3 (hSIRT3)
  • SIR2-like protein 3 (hSIRT3)
  • SIR3
Gene names SIRT3 (SIR2L3)
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 11

Isoforms

  • Isoform 2 of NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Q9NTG7-2): sequence view | extended view

Sequence

        10         20         30         40         50         60 
MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL RGSHGARGEP 
        70         80         90        100        110        120 
LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR SISFSVGASS VVGSGGSSDK 
       130        140        150        160        170        180 
GKLSLQDVAE LIRARACQRV VVMVGAGIST PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF 
       190        200        210        220        230        240 
ELPFFFHNPK PFFTLAKELY PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP 
       250        260        270        280        290        300 
ASKLVEAHGT FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ 
       310        320        330        340        350        360 
RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP LAWHPRSRDV 
       370        380        390    
AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
Chains:

 
 
N-termini:

NN
N
NN
 
C-termini:
C
C
 
Features:
  
 
Binding & active sites:
          
 
Sequence variations:
 
          
 
unknown-0KMAFWG...
0,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,399,399,0 CHAIN - NAD-dependent protein deacetylase sirtuin-3, mitochondrial. (0|399)
 
unknown-105SVGASS...
105,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 
unknown-110SVVGSG...
110,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_DB_Doxo direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_bortezomib direct yes 0.02 (ProteinProspector)
Wells Jurkat_untreated direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
Wells MM1SDBJurkat_Untreated direct yes 0.02 (ProteinProspector)
Wells apoptotic_MM1SDBJurkat_Mix direct yes 0.02 (ProteinProspector)
Wells apoptosis_U266_bortezomib_induced direct yes 0.02 (ProteinProspector)
 
unknown-111VVGSGG...
111,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells DB_Untreated direct yes 0.02 (ProteinProspector)
Wells apoptotic_DB_Doxo direct yes 0.02 (ProteinProspector)
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 
unknown-143MVGAGI...
143,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from isoform by sequence similarity TopFIND inferred from TNt89792 indirect unknown (unknown)
 

Protein C-Termini [export]

...DGPDK399-unknown
399,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Gevaert K. Van Damme P et al.: Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

399,399,399,0 CHAIN - NAD-dependent protein deacetylase sirtuin-3, mitochondrial. (0|399)
 
...DGPDK399-unknown
399,399

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from isoform by sequence similarity TopFIND inferred from TCt85410 indirect unknown (unknown)
Gevaert K. Van Damme P et al.: Complementary positional proteomics for screening substrates... direct yes 0.0 (unknown)

Affected feature boundaries: ?

399,399,399,0 CHAIN - NAD-dependent protein deacetylase sirtuin-3, mitochondrial. (0|399)
 
Filter by evidence: ?

Directness ?

  • unknown
  • direct
  • indirect

Physiological relevance ?

  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?