Q9UQC9: Calcium-activated chloride channel regulator 2 (Human)

Protein names
  • Calcium-activated chloride channel regulator 2
  • Calcium-activated chloride channel family member 2 Short=hCLCA2
  • Calcium-activated chloride channel protein 3 Short=CaCC-3 Short=hCaCC-3
  • CLCA2
Gene names CLCA2 (CACC3)
Organism Homo sapiens
Protease Family M87 (MEROPS)
Protease ID M87.003 (MEROPS)
Chromosome 1

Sequence

        10         20         30         40         50         60 
MTQRSIAGPI CNLKFVTLLV ALSSELPFLG AGVQLQDNGY NGLLIAINPQ VPENQNLISN 
        70         80         90        100        110        120 
IKEMITEASF YLFNATKRRV FFRNIKILIP ATWKANNNSK IKQESYEKAN VIVTDWYGAH 
       130        140        150        160        170        180 
GDDPYTLQYR GCGKEGKYIH FTPNFLLNDN LTAGYGSRGR VFVHEWAHLR WGVFDEYNND 
       190        200        210        220        230        240 
KPFYINGQNQ IKVTRCSSDI TGIFVCEKGP CPQENCIISK LFKEGCTFIY NSTQNATASI 
       250        260        270        280        290        300 
MFMQSLSSVV EFCNASTHNQ EAPNLQNQMC SLRSAWDVIT DSADFHHSFP MNGTELPPPP 
       310        320        330        340        350        360 
TFSLVQAGDK VVCLVLDVSS KMAEADRLLQ LQQAAEFYLM QIVEIHTFVG IASFDSKGEI 
       370        380        390        400        410        420 
RAQLHQINSN DDRKLLVSYL PTTVSAKTDI SICSGLKKGF EVVEKLNGKA YGSVMILVTS 
       430        440        450        460        470        480 
GDDKLLGNCL PTVLSSGSTI HSIALGSSAA PNLEELSRLT GGLKFFVPDI SNSNSMIDAF 
       490        500        510        520        530        540 
SRISSGTGDI FQQHIQLEST GENVKPHHQL KNTVTVDNTV GNDTMFLVTW QASGPPEIIL 
       550        560        570        580        590        600 
FDPDGRKYYT NNFITNLTFR TASLWIPGTA KPGHWTYTLN NTHHSLQALK VTVTSRASNS 
       610        620        630        640        650        660 
AVPPATVEAF VERDSLHFPH PVMIYANVKQ GFYPILNATV TATVEPETGD PVTLRLLDDG 
       670        680        690        700        710        720 
AGADVIKNDG IYSRYFFSFA ANGRYSLKVH VNHSPSISTP AHSIPGSHAM YVPGYTANGN 
       730        740        750        760        770        780 
IQMNAPRKSV GRNEEERKWG FSRVSSGGSF SVLGVPAGPH PDVFPPCKII DLEAVKVEEE 
       790        800        810        820        830        840 
LTLSWTAPGE DFDQGQATSY EIRMSKSLQN IQDDFNNAIL VNTSKRNPQQ AGIREIFTFS 
       850        860        870        880        890        900 
PQISTNGPEH QPNGETHESH RIYVAIRAMD RNSLQSAVSN IAQAPLFIPP NSDPVPARDY 
       910        920        930        940    
LILKGVLTAM GLIGIICLII VVTHHTLSRK KRADKKENGT KLL

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
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Chains:
 
 
 
 
N-termini:

NN
NN
 
C-termini:

CCC
 
Cleavage sites:
 
 
Features:
  
 
Sequence variations:
            
 
Topology:
   
 
(IPGSH(708)|(709)AMYVP)
708,943

Calcium-activated chloride channel regulator 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Brett TJ Yurtsever Z et al.:Self-cleavage of human CLCA1 pr... (M87.001) unknown yes

Targeted features: ?

708,943,901,32 TOPO_DOM - Extracellular (Potential). (32|901)
708,943,943,32 CHAIN - Calcium-activated chloride channel regulator 2. (32|943)
708,943,943,0 CHAIN - Calcium-activated chloride channel regulator 2, 35 kDa form. (0|943)
 
unknown-0LMTQRS...
0,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,943,943,0 CHAIN - Calcium-activated chloride channel regulator 2, 35 kDa form. (0|943)
 
unknown-32GVQLQD...
32,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

32,943,901,32 TOPO_DOM - Extracellular (Potential). (32|901)
32,943,943,32 CHAIN - Calcium-activated chloride channel regulator 2. (32|943)
 
unknown-33VQLQDN...
33,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

33,943,0,33 CHAIN - Calcium-activated chloride channel regulator 2, 109 kDa form. (33|0)
 
unknown-709AMYVPG...
709,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC8364 indirect unknown (unknown)
 

Protein C-Termini [export]

...GTKLL0-unknown
0,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,943,0,33 CHAIN - Calcium-activated chloride channel regulator 2, 109 kDa form. (33|0)
 
...IPGSH708-unknown
708,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC8364 indirect unknown (unknown)
 
...GTKLL943-unknown
943,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

943,943,943,923 TOPO_DOM - Cytoplasmic (Potential). (923|943)
943,943,943,32 CHAIN - Calcium-activated chloride channel regulator 2. (32|943)
943,943,943,0 CHAIN - Calcium-activated chloride channel regulator 2, 35 kDa form. (0|943)
 
708 (PGSH.|.AMYV)
708,943

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Brett TJ Yurtsever Z et al.:Self-cleavage of human CLCA1 pr... (M87.001) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?