Q9Y287: Integral membrane protein 2B (Human)

Protein names
  • Integral membrane protein 2B
  • Immature BRI2 Short=imBRI2
  • Protein E25B
  • Transmembrane protein BRI Short=Bri
  • ITM2B
Gene names ITM2B (BRI, BRI2)
Organism Homo sapiens
Protease Family (Not Available)
Protease ID (Not Available)
Chromosome 13

Sequence

        10         20         30         40         50         60 
MVKVTFNSAL AQKEAKKDEP KSGEEALIIP PDAVAVDCKD PDDVVPVGQR RAWCWCMCFG 
        70         80         90        100        110        120 
LAFMLAGVIL GGAYLYKYFA LQPDDVYYCG IKYIKDDVIL NEPSADAPAA LYQTIEENIK 
       130        140        150        160        170        180 
IFEEEEVEFI SVPVPEFADS DPANIVHDFN KKLTAYLDLN LDKCYVIPLN TSIVMPPRNL 
       190        200        210        220        230        240 
LELLINIKAG TYLPQSYLIH EHMVITDRIE NIDHLGFFIY RLCHDKETYK LQRRETIKGI 
       250        260    
QKREASNCFA IRHFENKFAV ETLICS

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
Chains:
 
 
 
 
 
N-termini:

N
N
N
NNNN
 
C-termini:

CCC
 
Cleavage sites:
 
 
Features:
   
 
 
Sequence variations:
    
 
 
Topology:
   
 
(GIQKR(243)|(244)EASNC)
243,266

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Merops FURIN_HUMAN -> ITM2B_HUMAN @243 unknown yes

Targeted features: ?

243,266,266,76 TOPO_DOM - Lumenal (Potential). (76|266)
243,266,266,1 CHAIN - Integral membrane protein 2B. (1|266)

Affected feature boundaries: ?

243,266,244,243 MUTAGEN - RE->AA: Inhibits cleavage by furin. Does not prevent ADAM10 shedding. (243|244)
243,266,244,243 SITE - Cleavage; by furin. (243|244)
243,266,266,244 PEPTIDE - Bri23 peptide. (244|266)
243,266,243,1 CHAIN - BRI2, membrane form. (1|243)
243,266,243,0 CHAIN - BRI2C, soluble form. (0|243)
 
unknown-0SMVKVT...
0,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,266,243,0 CHAIN - BRI2C, soluble form. (0|243)
 
unknown-1MVKVTF...
1,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

1,266,54,1 TOPO_DOM - Cytoplasmic (Potential). (1|54)
1,266,266,1 CHAIN - Integral membrane protein 2B. (1|266)
1,266,243,1 CHAIN - BRI2, membrane form. (1|243)
1,266,0,1 CHAIN - BRI2 intracellular domain. (1|0)
 
unknown-4VTFNSA...
4,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... unknown unknown (unknown)
 
unknown-4VTFNSA...
4,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells Jurkat_untreated direct yes 0.02 (ProteinProspector)
 
unknown-111LYQTIE...
111,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 
unknown-131SVPVPE...
131,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
Wells apoptotic_Jurkat_staurotrail direct yes 0.02 (ProteinProspector)
 
unknown-244EASNCF...
244,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC9857 indirect unknown (unknown)

Affected feature boundaries: ?

244,266,266,244 PEPTIDE - Bri23 peptide. (244|266)
 

Protein C-Termini [export]

...TLICS0-unknown
0,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,266,0,1 CHAIN - BRI2 intracellular domain. (1|0)
 
...GIQKR243-unknown
243,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9857 indirect unknown (unknown)

Affected feature boundaries: ?

243,266,243,1 CHAIN - BRI2, membrane form. (1|243)
243,266,243,0 CHAIN - BRI2C, soluble form. (0|243)
 
...TLICS266-unknown
266,266

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

266,266,266,244 PEPTIDE - Bri23 peptide. (244|266)
266,266,266,76 TOPO_DOM - Lumenal (Potential). (76|266)
266,266,266,1 CHAIN - Integral membrane protein 2B. (1|266)
266,266,266,266 VARIANT - S -> FNLFLNSQEKHY (in CAA-ITM2B2; amyloid ADan; colocalizes with APP beta-amyloid protein 42 in parenchymal and vascular lesions; interacts with APP beta-amyloid 42; oligomerizes and is subjected to disulfide bond formation; undergoes cyclic pyroglutamate (266|266)
266,266,266,266 VARIANT - S -> SRTVKKNIIEEN (in CAA-ITM2B1; amyloid ABri). (266|266)
 
Filter by evidence: ?

Directness ?

  • unknown
  • direct
  • indirect

Physiological relevance ?

  • yes
  • unknown

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown
  • ProteinProspector

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?