Q9Y5R2: Matrix metalloproteinase-24 (Human)

Protein names
  • Matrix metalloproteinase-24 (MMP-24)
  • Membrane-type matrix metalloproteinase 5 Short=MT-MMP 5 Short=MTMMP5 (MMP-24)
  • Membrane-type-5 matrix metalloproteinase Short=MT5-MMP Short=MT5MMP (MMP-24)
  • MMP24
Gene names MMP24
Organism Homo sapiens
Protease Family M10 (MEROPS)
Protease ID M10.023 (MEROPS)
Chromosome 20

Sequence

        10         20         30         40         50         60 
MPRSRGGRAA PGPPPPPPPP GQAPRWSRWR VPGRLLLLLL PALCCLPGAA RAAAAAAGAG 
        70         80         90        100        110        120 
NRAAVAVAVA RADEAEAPFA GQNWLKSYGY LLPYDSRASA LHSAKALQSA VSTMQQFYGI 
       130        140        150        160        170        180 
PVTGVLDQTT IEWMKKPRCG VPDHPHLSRR RRNKRYALTG QKWRQKHITY SIHNYTPKVG 
       190        200        210        220        230        240 
ELDTRKAIRQ AFDVWQKVTP LTFEEVPYHE IKSDRKEADI MIFFASGFHG DSSPFDGEGG 
       250        260        270        280        290        300 
FLAHAYFPGP GIGGDTHFDS DEPWTLGNAN HDGNDLFLVA VHELGHALGL EHSSDPSAIM 
       310        320        330        340        350        360 
APFYQYMETH NFKLPQDDLQ GIQKIYGPPA EPLEPTRPLP TLPVRRIHSP SERKHERQPR 
       370        380        390        400        410        420 
PPRPPLGDRP STPGTKPNIC DGNFNTVALF RGEMFVFKDR WFWRLRNNRV QEGYPMQIEQ 
       430        440        450        460        470        480 
FWKGLPARID AAYERADGRF VFFKGDKYWV FKEVTVEPGY PHSLGELGSC LPREGIDTAL 
       490        500        510        520        530        540 
RWEPVGKTYF FKGERYWRYS EERRATDPGY PKPITVWKGI PQAPQGAFIS KEGYYTYFYK 
       550        560        570        580        590        600 
GRDYWKFDNQ KLSVEPGYPR NILRDWMGCN QKEVERRKER RLPQDDVDIM VTINDVPGSV 
       610        620        630        640    
NAVAVVIPCI LSLCILVLVY TIFQFKNKTG PQPVTYYKRP VQEWV

Annotation ?

Network neighborhood
[show protein-protein interactions]
 
100
200
300
400
500
600
Chains:
 
 
 
N-termini:
NN
 
C-termini:

CCC
 
Cleavage sites:
 
 
 
 
 
 
 
Features:
  
 
 
Binding & active sites:
     
 
Sequence variations:
 
 
Topology:
 
      
 
(RRNKR(155)|(156)YALTG)
155,645

Neuroendocrine convertase 2 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 4 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 6 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Furin (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 5 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Proprotein convertase subtilisin/kexin type 7 (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Strongin AY Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) unknown unknown

Targeted features: ?

155,645,602,53 TOPO_DOM - Extracellular (Potential). (53|602)

Affected feature boundaries: ?

155,645,645,156 CHAIN - Matrix metalloproteinase-24. (156|645)
155,645,0,156 CHAIN - Processed matrix metalloproteinase-24. (156|0)
155,645,155,53 PROPEP - By similarity. (53|155)
 
unknown-53AAAAAG...
53,645

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

53,645,602,53 TOPO_DOM - Extracellular (Potential). (53|602)
53,645,155,53 PROPEP - By similarity. (53|155)
 
unknown-156YALTGQ...
156,645

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26664 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26936 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27234 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9858 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27086 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27381 indirect unknown (unknown)

Affected feature boundaries: ?

156,645,645,156 CHAIN - Matrix metalloproteinase-24. (156|645)
156,645,0,156 CHAIN - Processed matrix metalloproteinase-24. (156|0)
 

Protein C-Termini [export]

...VQEWV0-unknown
0,645

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

0,645,0,156 CHAIN - Processed matrix metalloproteinase-24. (156|0)
 
...RRNKR155-unknown
155,645

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from cleavage TopFIND Inferred from cleavage TC26664 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC26936 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27234 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC9858 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27086 indirect unknown (unknown)
inferred from cleavage TopFIND Inferred from cleavage TC27381 indirect unknown (unknown)

Affected feature boundaries: ?

155,645,155,53 PROPEP - By similarity. (53|155)
 
...VQEWV645-unknown
645,645

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance Confidence
inferred from electronic annotation UniProtKB inferred from uniprot unknown unknown 0.0 (unknown)

Affected feature boundaries: ?

645,645,645,624 TOPO_DOM - Cytoplasmic (Potential). (624|645)
645,645,645,156 CHAIN - Matrix metalloproteinase-24. (156|645)
 
118 (NSFG.|.LRFG)
118,138

Evidence: (more...)

Evidence ? Source (database) ? Source (laboratory) ? Name ? Directness of identification ? Phys Relevance
inferred from experiment MEROPS Sato H Takino T et al.:Cleavage of metastasis suppress... (M10.014) unknown yes
 
Filter by evidence: ?

Directness ?

  • unknown
  • indirect

Physiological relevance ?

  • unknown
  • yes

Evidencecode ?

Method ?

Perturbation ?

Confidence greater than?

  • unknown

Experimental system ?

Certainty of Protease assignment ?

  • unknown

Evidencecode ?

Tissue distribution ?

Specific evidence ?

Derived from database?

Laboratory ?