PathFINDer is TopFIND's protease web explorer inspired by Fortelny et al, PLoS Biology, 2014.
The protease web is a network of proteases and their inhibitors. Proteases cleave
other proteases and inhibitors of other proteases in vivo. Changes of the activity
of one protease can thereby influence the cleavage of substrates of other proteases
indirectly. PathFINDer uses a graph to model known protease interactions as a
network and finds paths in this network. These paths represent biological pathways
thus enabling mechanistic insights.
Network from organism
Proteins are from organism
Protease UniProt ID
Substrate UniProt IDs and cleavage positions
Maximum path length
Find cleavages on substrates at the indicated position only
yes with range
to prime aminoacids