PathFINDer

Description:

PathFINDer is TopFIND's protease web explorer inspired by Fortelny et al, PLoS Biology, 2014.
The protease web is a network of proteases and their inhibitors. Proteases cleave
other proteases and inhibitors of other proteases in vivo. Changes of the activity
of one protease can thereby influence the cleavage of substrates of other proteases
indirectly. PathFINDer uses a graph to model known protease interactions as a
network and finds paths in this network. These paths represent biological pathways
thus enabling mechanistic insights.

More information and citation: Fortelny et al, NAR, 2014 [pdf]



Network from organism ?
human
mouse


Proteins are from organism ?
human
mouse


Protease UniProt ID ?


Substrate UniProt IDs and cleavage positions ?


Maximum path length ?


Find cleavages on substrates at the indicated position only ?
yes with range
from non-prime
to prime aminoacids
no